Imperial College London
Alternate

Dr Aida Martinez-Sanchez

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3366a.martinez-sanchez Website

 
 
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Location

 

326ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Martinez-Sanchez:2013:10.3390/biology2010189,
author = {Martinez-Sanchez, A and Murphy, C},
doi = {10.3390/biology2010189},
journal = {Biology},
pages = {189--205},
title = {MicroRNA Target Identification—Experimental Approaches},
url = {http://dx.doi.org/10.3390/biology2010189},
volume = {2},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - MicroRNAs (miRNAs) are small non-coding RNA molecules of 21–23 nucleotides that control gene expression at the post-transcriptional level. They have been shown to play a vital role in a wide variety of biological processes and dysregulated expression of miRNAs is observed in many pathologies. Understanding the mechanism of action and identifying functionally important mRNA targets of a specific miRNA are essential to unravelling its biological function and to assist miRNA-based drug development. This review summarizes the current understanding of the mechanistic aspects of miRNA-mediated gene repression and focuses on the different approaches for miRNA target identification that have been proposed in recent years.
AU  - Martinez-Sanchez,A
AU  - Murphy,C
DO  - 10.3390/biology2010189
EP  - 205
PY  - 2013///
SN  - 2079-7737
SP  - 189
TI  - MicroRNA Target Identification—Experimental Approaches
T2  - Biology
UR  - http://dx.doi.org/10.3390/biology2010189
UR  - http://hdl.handle.net/10044/1/40459
VL  - 2
ER  -
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