Imperial College London
Alternate

Dr Aida Martinez-Sanchez

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3366a.martinez-sanchez Website

 
 
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Location

 

326ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yavari:2016:10.1016/j.cmet.2016.04.003,
author = {Yavari, A and Stocker, CJ and Ghaffari, S and Wargent, ET and Steeples, V and Czibik, G and Pinter, K and Bellahcene, M and Woods, A and Martínez, de Morentin PB and Cansell, C and Lam, BY and Chuster, A and Petkevicius, K and Nguyen-Tu, MS and Martinez-Sanchez, A and Pullen, TJ and Oliver, PL and Stockenhuber, A and Nguyen, C and Lazdam, M and O'Dowd, JF and Harikumar, P and Tóth, M and Beall, C and Kyriakou, T and Parnis, J and Sarma, D and Katritsis, G and Wortmann, DD and Harper, AR and Brown, LA and Willows, R and Gandra, S and Poncio, V and de, Oliveira Figueiredo MJ and Qi, NR and Peirson, SN and McCrimmon, RJ and Gereben, B and Tretter, L and Fekete, C and Redwood, C and Yeo, GS and Heisler, LK and Rutter, GA and Smith, MA and Withers, DJ and Carling, D and Sternick, EB and Arch, JR and Cawthorne, MA and Watkins, H and Ashrafian, H},
doi = {10.1016/j.cmet.2016.04.003},
journal = {Cell Metabolism},
pages = {821--836},
title = {Chronic activation of γ2 AMPK induces obesity and reduces β cell function},
url = {http://dx.doi.org/10.1016/j.cmet.2016.04.003},
volume = {23},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strategy for the treatment of obesity and its complications. AMPK is a conserved, ubiquitously expressed, heterotrimeric serine/threonine kinase whose short-term activation has multiple beneficial metabolic effects. Whether these translate into long-term benefits for obesity and its complications is unknown. Here, we observe that mice with chronic AMPK activation, resulting from mutation of the AMPK γ2 subunit, exhibit ghrelin signaling-dependent hyperphagia, obesity, and impaired pancreatic islet insulin secretion. Humans bearing the homologous mutation manifest a congruent phenotype. Our studies highlight that long-term AMPK activation throughout all tissues can have adverse metabolic consequences, with implications for pharmacological strategies seeking to chronically activate AMPK systemically to treat metabolic disease.
AU  - Yavari,A
AU  - Stocker,CJ
AU  - Ghaffari,S
AU  - Wargent,ET
AU  - Steeples,V
AU  - Czibik,G
AU  - Pinter,K
AU  - Bellahcene,M
AU  - Woods,A
AU  - Martínez,de Morentin PB
AU  - Cansell,C
AU  - Lam,BY
AU  - Chuster,A
AU  - Petkevicius,K
AU  - Nguyen-Tu,MS
AU  - Martinez-Sanchez,A
AU  - Pullen,TJ
AU  - Oliver,PL
AU  - Stockenhuber,A
AU  - Nguyen,C
AU  - Lazdam,M
AU  - O'Dowd,JF
AU  - Harikumar,P
AU  - Tóth,M
AU  - Beall,C
AU  - Kyriakou,T
AU  - Parnis,J
AU  - Sarma,D
AU  - Katritsis,G
AU  - Wortmann,DD
AU  - Harper,AR
AU  - Brown,LA
AU  - Willows,R
AU  - Gandra,S
AU  - Poncio,V
AU  - de,Oliveira Figueiredo MJ
AU  - Qi,NR
AU  - Peirson,SN
AU  - McCrimmon,RJ
AU  - Gereben,B
AU  - Tretter,L
AU  - Fekete,C
AU  - Redwood,C
AU  - Yeo,GS
AU  - Heisler,LK
AU  - Rutter,GA
AU  - Smith,MA
AU  - Withers,DJ
AU  - Carling,D
AU  - Sternick,EB
AU  - Arch,JR
AU  - Cawthorne,MA
AU  - Watkins,H
AU  - Ashrafian,H
DO  - 10.1016/j.cmet.2016.04.003
EP  - 836
PY  - 2016///
SN  - 1932-7420
SP  - 821
TI  - Chronic activation of γ2 AMPK induces obesity and reduces β cell function
T2  - Cell Metabolism
UR  - http://dx.doi.org/10.1016/j.cmet.2016.04.003
UR  - https://www.sciencedirect.com/science/article/pii/S1550413116301231?via%3Dihub
UR  - http://hdl.handle.net/10044/1/32944
VL  - 23
ER  -
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