Imperial College London
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DrAngelaMeccariello

Faculty of Natural Sciences, Department of Life Sciences

Imperial College Research Fellow
 
 
 
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a.meccariello

 
 
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Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Papanicolaou:2016:10.1186/s13059-016-1049-2,
author = {Papanicolaou, A and Schetelig, MF and Arensburger, P and Atkinson, PW and Benoit, JB and Bourtzis, K and Castanera, P and Cavanaugh, JP and Chao, H and Childers, C and Curril, I and Huyen, D and Doddapaneni, H and Dolan, A and Dugan, S and Friedrich, M and Gasperi, G and Geib, S and Georgakilas, G and Gibbs, RA and Giers, SD and Gomulski, LM and Gonzalez-Guzman, M and Guillem-Amat, A and Han, Y and Hatzigeorgiou, AG and Hernandez-Crespo, P and Hughes, DST and Jones, JW and Karagkouni, D and Koskinioti, P and Lee, SL and Malacrida, AR and Manni, M and Mathiopoulos, K and Meccariello, A and Murali, SC and Murphy, TD and Muzny, DM and Oberhofer, G and Ortego, F and Paraskevopoulou, MD and Poelchau, M and Qu, J and Reczko, M and Robertson, HM and Rosendale, AJ and Rosselot, AE and Saccone, G and Salvemini, M and Savini, G and Schreiner, P and Scolari, F and Siciliano, P and Sim, SB and Tsiamis, G and Urena, E and Vlachos, IS and Werren, JH and Wimmer, EA and Worley, KC and Zacharopoulou, A},
doi = {10.1186/s13059-016-1049-2},
journal = {Genome Biology},
title = {The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species},
url = {http://dx.doi.org/10.1186/s13059-016-1049-2},
volume = {17},
year = {2016}
}
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TY  - JOUR
AB  - BackgroundThe Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It exhibits a unique ability to invade and adapt to ecological niches throughout tropical and subtropical regions of the world, though medfly infestations have been prevented and controlled by the sterile insect technique (SIT) as part of integrated pest management programs (IPMs). The genetic analysis and manipulation of medfly has been subject to intensive study in an effort to improve SIT efficacy and other aspects of IPM control.ResultsThe 479 Mb medfly genome is sequenced from adult flies from lines inbred for 20 generations. A high-quality assembly is achieved having a contig N50 of 45.7 kb and scaffold N50 of 4.06 Mb. In-depth curation of more than 1800 messenger RNAs shows specific gene expansions that can be related to invasiveness and host adaptation, including gene families for chemoreception, toxin and insecticide metabolism, cuticle proteins, opsins, and aquaporins. We identify genes relevant to IPM control, including those required to improve SIT.ConclusionsThe medfly genome sequence provides critical insights into the biology of one of the most serious and widespread agricultural pests. This knowledge should significantly advance the means of controlling the size and invasive potential of medfly populations. Its close relationship to Drosophila, and other insect species important to agriculture and human health, will further comparative functional and structural studies of insect genomes that should broaden our understanding of gene family evolution.
AU  - Papanicolaou,A
AU  - Schetelig,MF
AU  - Arensburger,P
AU  - Atkinson,PW
AU  - Benoit,JB
AU  - Bourtzis,K
AU  - Castanera,P
AU  - Cavanaugh,JP
AU  - Chao,H
AU  - Childers,C
AU  - Curril,I
AU  - Huyen,D
AU  - Doddapaneni,H
AU  - Dolan,A
AU  - Dugan,S
AU  - Friedrich,M
AU  - Gasperi,G
AU  - Geib,S
AU  - Georgakilas,G
AU  - Gibbs,RA
AU  - Giers,SD
AU  - Gomulski,LM
AU  - Gonzalez-Guzman,M
AU  - Guillem-Amat,A
AU  - Han,Y
AU  - Hatzigeorgiou,AG
AU  - Hernandez-Crespo,P
AU  - Hughes,DST
AU  - Jones,JW
AU  - Karagkouni,D
AU  - Koskinioti,P
AU  - Lee,SL
AU  - Malacrida,AR
AU  - Manni,M
AU  - Mathiopoulos,K
AU  - Meccariello,A
AU  - Murali,SC
AU  - Murphy,TD
AU  - Muzny,DM
AU  - Oberhofer,G
AU  - Ortego,F
AU  - Paraskevopoulou,MD
AU  - Poelchau,M
AU  - Qu,J
AU  - Reczko,M
AU  - Robertson,HM
AU  - Rosendale,AJ
AU  - Rosselot,AE
AU  - Saccone,G
AU  - Salvemini,M
AU  - Savini,G
AU  - Schreiner,P
AU  - Scolari,F
AU  - Siciliano,P
AU  - Sim,SB
AU  - Tsiamis,G
AU  - Urena,E
AU  - Vlachos,IS
AU  - Werren,JH
AU  - Wimmer,EA
AU  - Worley,KC
AU  - Zacharopoulou,A
AU  - Richards,S
AU  - Handler,AM
DO  - 10.1186/s13059-016-1049-2
PY  - 2016///
SN  - 1474-7596
TI  - The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species
T2  - Genome Biology
UR  - http://dx.doi.org/10.1186/s13059-016-1049-2
UR  - http://hdl.handle.net/10044/1/53082
VL  - 17
ER  -
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