Imperial College London

Dr Alex Miras

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7958 377 674a.miras

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

174 results found

Chuah LL, Baqai N, Graham C, Miras AD, Nicotra A, Khalil NM, Le Roux CWet al., 2013, Effect of Gastric Bypass Surgery on Diabetes Neuropathy, Publisher: AMER DIABETES ASSOC, Pages: A148-A148, ISSN: 0012-1797

Conference paper

Seyfried F, Li JV, Miras AD, Cluny NL, Lannoo M, Fenske WK, Sharkey KA, Nicholson JK, le Roux CW, Holmes Eet al., 2013, Urinary Phenotyping Indicates Weight Loss-Independent Metabolic Effects of Roux-en-Y Gastric Bypass in Mice, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 1245-1253, ISSN: 1535-3893

Journal article

Baqai N, Graham C, Chuah LL, Miras AD, Jonathan S, Jackson S, Lascaratos G, Olbers T, le Roux CWet al., 2013, Effects of bariatric surgery on retinopathy and nephropathy in patients with Type 2 diabetes, DIABETIC MEDICINE, Vol: 30, Pages: 13-13, ISSN: 0742-3071

Journal article

Papamargaritis D, Miras AD, le Roux CW, 2013, Influence of diabetes surgery on gut hormones and incretins, NUTRICION HOSPITALARIA, Vol: 28, Pages: 95-103, ISSN: 0212-1611

Journal article

Miras AD, Chuah LL, Lascaratos G, Faruq S, Mohite AA, Shah PR, Gill M, Jackson SN, Johnston DG, Olbers T, le Roux CWet al., 2012, Bariatric Surgery Does Not Exacerbate and May Be Beneficial for the Microvascular Complications of Type 2 Diabetes, DIABETES CARE, Vol: 35, Pages: E81-E81, ISSN: 0149-5992

Journal article

Papamargaritis D, Panteliou E, Miras AD, le Roux CWet al., 2012, Mechanisms of Weight Loss, Diabetes Control and Changes in Food Choices After Gastrointestinal Surgery, CURRENT ATHEROSCLEROSIS REPORTS, Vol: 14, Pages: 616-623, ISSN: 1523-3804

Journal article

Miras AD, Jackson RN, Jackson SN, Goldstone AP, Olbers T, Hackenberg T, Spector AC, le Roux CWet al., 2012, Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 96, Pages: 467-473, ISSN: 0002-9165

Journal article

Apostolopoulou M, Michalakis K, Miras A, Hatzitolios A, Savopoulos Cet al., 2012, Nutrition in the primary and secondary prevention of stroke, MATURITAS, Vol: 72, Pages: 29-34, ISSN: 0378-5122

Journal article

Miras AD, Le Roux CW, 2012, Gastrointestinal Physiology in Obesity, Critical Care Management of the Obese Patient, Pages: 21-27, ISBN: 9780470655900

Obesity is associated with a higher risk of developing a number of gastrointestinal conditions ranging from relatively benign gastroesophageal reflux disease and asymptomatic gallstones to cancers of all major gastrointestinal tract organs. Nonalcoholic fatty liver disease is very common in the context of obesity and can lead to liver cirrhosis, while obese patients are more susceptible to the development of severe pancreatitis. Disturbed balance of the gut flora can lead to a higher energy yield from ingested diet and contribute to obesity, whilst manipulation of this altered ecology may prove to be a future treatment for obesity. There is a need for high-quality research to elucidate the pathophysiology of obesity and gastrointestinal disease before novel therapies can be developed for both. © 2012 John Wiley & Sons, Ltd.

Book chapter

Fenske WK, Bueter M, Miras AD, Ghatei MA, Bloom SR, le Roux CWet al., 2012, Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass, INTERNATIONAL JOURNAL OF OBESITY, Vol: 36, Pages: 379-384, ISSN: 0307-0565

Journal article

Fenske WK, Pournaras DJ, Aasheim ET, Miras AD, Scopinaro N, Scholtz S, le Roux CWet al., 2012, Can a Protocol for Glycaemic Control Improve Type 2 Diabetes Outcomes After Gastric Bypass?, OBESITY SURGERY, Vol: 22, Pages: 90-96, ISSN: 0960-8923

Journal article

Savopoulos C, Michalakis K, Apostolopoulou M, Miras A, Hatzitolios Aet al., 2011, Adipokines and stroke: A review of the literature, MATURITAS, Vol: 70, Pages: 322-327, ISSN: 0378-5122

Journal article

Scholtz S, Chhina N, Miras AD, Prechtl CG, Durighel G, Ahmed A, Olbers T, Mona-Nwinia W, le Roux C, Bell JD, Goldstone APet al., 2011, Obese Patients After Gastric Bypass Surgery Have Different Brain Reward Responses to High-Calorie Food and Healthier Eating Behaviour Compared to Gastric Banding, 29th Annual Scientific Meeting of the Obesity-Society, Publisher: NATURE PUBLISHING GROUP, Pages: S59-S59, ISSN: 1930-7381

Conference paper

Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, Unwin RJ, Lutz TA, Spector AC, le Roux CWet al., 2011, Alterations of sucrose preference after Roux-en-Y gastric bypass, PHYSIOLOGY & BEHAVIOR, Vol: 104, Pages: 709-721, ISSN: 0031-9384

Journal article

Savopoulos CG, Apostolopoulou M, Miras A, Hatzitolios AIet al., 2011, Stroke, obesity and gender. Is there actually any relation regardless of age?, MATURITAS, Vol: 70, Pages: 92-93, ISSN: 0378-5122

Journal article

Bueter M, Seyfried F, Fenske WK, Miras AD, Ghatei MA, Bloom SR, le Roux CWet al., 2011, Exogenous Peptide YY 3-36 and Exendin-4 Further Decrease Food Intake, While Octreotide Increases Food Intake in Rats after Roux-En-Y Gastric Bypass, 16th Congress of the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), Publisher: SPRINGER, Pages: 1127-1127, ISSN: 0960-8923

Conference paper

Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, Unwin RJ, Lutz TA, Spector AC, le Roux CWet al., 2011, Alterations of Sucrose Preference after Roux-En-Y Gastric Bypass, 16th Congress of the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), Publisher: SPRINGER, Pages: 1127-1127, ISSN: 0960-8923

Conference paper

Miras AD, le Roux CW, 2010, Bariatric surgery and taste: novel mechanisms of weight loss, CURRENT OPINION IN GASTROENTEROLOGY, Vol: 26, Pages: 140-145, ISSN: 0267-1379

Journal article

Miras AD, Ward H, 2010, Encephalopathy following diabetic ketoacidosis in a type 1 diabetes patient, Practical Diabetes International, Vol: 27, Pages: 76-78i, ISSN: 1357-8170

A 44-year-old gentleman with type 1 diabetes mellitus was found collapsed with diabetic ketoacidosis. Following correction of the metabolic derangements his level of consciousness improved but he became encephalopathic, exhibiting unprecedented aggression with non-specific neurological signs. This profound neurological state persisted for one month. Reversible causes of encephalopathy were investigated and excluded. The patient made a slow and almost complete recovery over a period of six months. Encephalopathy is an unusual complication of hyperglycaemic emergencies with poorly understood underlying mechanisms. This case demonstrates the importance of considering and treating the numerous reversible causes of an encephalopathic state before attributing altered levels of consciousness to the acute metabolic disturbances only. Copyright © 2010 John Wiley & Sons.

Journal article

Miras AD, le Roux CW, 2010, Management of obesity in polycystic ovary syndrome, including anti–obesity drugs and bariatric surgery, Current Management of Polycystic Ovary Syndrome, Pages: 105-116, ISBN: 9781906985417

Introduction The interaction between excess adiposity and disturbed female fertility is best represented by polycystic ovary syndrome (PCOS). This syndrome has been studied by both gynaecologists and endocrinologists as the mechanisms leading to its diverse manifestations are complex. PCOS is very common in the developed world, with up to 10% of premenopausal women being affected. Clinically, PCOS is characterised by the development of hirsutism, oligo-ovulation/anovulation and subfertility/infertility. The pathophysiology of the syndrome, even though not yet fully delineated, implicates insulin resistance as a central factor as it leads to hyperinsulinaemia and androgen excess. High circulating insulin levels inhibit the production of sex hormone-binding globulin (SHBG) from the liver and directly cause excess androgen production at the level of the ovary. These two processes lead to the aesthetically troublesome hirsutism and contribute to irregular menses or even cause secondary amenorrhoea. However, it is even more worrying that women with PCOS are at increased risk of cardiovascular mortality and morbidity owing to their occult disturbed metabolism, which shares features of the metabolic syndrome. These include impaired glucose tolerance and type 2 diabetes, hypertension, dyslipidaemia and increased waist circumference. Approximately 40% of women living in the developed world are obese or overweight. The prevalence of obesity in women with PCOS varies widely, from 10% to 70% of cases. Modest weight loss can, however, reverse many of the features of the syndrome and lower the cardiometabolic risk profile. This review focuses on the treatment of obesity in the context of PCOS with antiobesity medication and obesity (bariatric) surgery. Metformin and rimonabant are not reviewed here as the former is an insulin sensitiser and its effects on weight reduction in women with PCOS have been discouraging and the latter has been withdrawn from the market.

Book chapter

Jones DA, Miras A, Tringham JR, 2008, Addison's disease: a diagnostic challenge, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 69, Pages: M192-M195, ISSN: 1750-8460

Journal article

Khan SA, Miras A, Pelling M, Taylor-Robinson SDet al., 2007, Cholangiocarcinoma and its management, GUT, Vol: 56, Pages: 1755-1756, ISSN: 0017-5749

Journal article

Voiglio EJ, Frattini B, Dörrzapf JJ, Breteau J, Miras A, Caillot JLet al., 2004, Ballistic study of the SAPL GC27 gun:: Is it really nonlethal"?, WORLD JOURNAL OF SURGERY, Vol: 28, Pages: 402-405, ISSN: 0364-2313

Journal article

Miras A, Morris K, Soper C, 2002, Hepatitis C virus prevalence in children in a highly endemic region of Egypt, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 21, Pages: 987-987, ISSN: 0891-3668

Journal article

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