Imperial College London
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Dr Alex Miras

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7958 377 674a.miras

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Diamanti-Kandarakis:2019:10.1530/EJE-19-0154,
author = {Diamanti-Kandarakis, E and Duntas, L and Kanakis, GA and Kandaraki, E and Karavitaki, N and Kassi, E and Livadas, S and Mastorakos, G and Migdalis, I and Miras, AD and Nader, S and Papalou, O and Poladian, R and Popovic, V and Rachon, D and Tigas, S and Tsigos, C and Tsilchorozidou, T and Tzotzas, T and Bargiota, A and Pfeifer, M},
doi = {10.1530/EJE-19-0154},
journal = {European Journal of Endocrinology},
pages = {R73--R105},
title = {Drug-induced endocrinopathies and diabetes: a combo-endocrinology overview},
url = {http://dx.doi.org/10.1530/EJE-19-0154},
volume = {181},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In the currently overwhelming era of polypharmacy, the balance of the dynamic and delicate endocrine system can easily be disturbed by interfering pharmaceutical agents like medications. Drugs can cause endocrine abnormalities via different mechanisms, including direct alteration of hormone production, changes in the regulation of the feedback axis, on hormonal transport, binding and signaling, as well as similar changes to counter-regulatory hormone systems. Furthermore, drugs can interfere with the hormonal assays, leading to erroneous laboratory results that disorientate clinicians from the right diagnosis. The purpose of this review is to cover a contemporary topic, the drug-induced endocrinopathies, which was presented in the monothematic annual Combo Endo Course 2018. This challenging part of endocrinology is constantly expanding particularly during the last decade, with the new oncological therapeutic agents, targeting novel molecular pathways in the process of malignancies. In this new context of drug-induced endocrine disease, clinicians should be aware that drugs can cause endocrine abnormalities via different mechanisms and mimic a variety of clinical scenarios. Therefore, it is extremely important for clinicians not only to promptly recognize drug-induced hormonal and metabolic abnormalities, but also to address the therapeutic issues for timely intervention.
AU  - Diamanti-Kandarakis,E
AU  - Duntas,L
AU  - Kanakis,GA
AU  - Kandaraki,E
AU  - Karavitaki,N
AU  - Kassi,E
AU  - Livadas,S
AU  - Mastorakos,G
AU  - Migdalis,I
AU  - Miras,AD
AU  - Nader,S
AU  - Papalou,O
AU  - Poladian,R
AU  - Popovic,V
AU  - Rachon,D
AU  - Tigas,S
AU  - Tsigos,C
AU  - Tsilchorozidou,T
AU  - Tzotzas,T
AU  - Bargiota,A
AU  - Pfeifer,M
DO  - 10.1530/EJE-19-0154
EP  - 105
PY  - 2019///
SN  - 0804-4643
SP  - 73
TI  - Drug-induced endocrinopathies and diabetes: a combo-endocrinology overview
T2  - European Journal of Endocrinology
UR  - http://dx.doi.org/10.1530/EJE-19-0154
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000472835100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://eje.bioscientifica.com/view/journals/eje/181/2/EJE-19-0154.xml
UR  - http://hdl.handle.net/10044/1/72481
VL  - 181
ER  -
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