Imperial College London
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Dr Alex Miras

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7958 377 674a.miras

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Perez-Pevida:2019:10.3389/fendo.2019.00641,
author = {Perez-Pevida, B and Escalada, J and Miras, AD and Fruhbeck, G},
doi = {10.3389/fendo.2019.00641},
journal = {Frontiers in Endocrinology},
pages = {1--9},
title = {Mechanisms underlying Type 2 diabetes remission after metabolic surgery},
url = {http://dx.doi.org/10.3389/fendo.2019.00641},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Type 2 diabetes prevalence is increasing dramatically worldwide. Metabolic surgery is the most effective treatment for selected patients with diabetes and/or obesity. When compared to intensive medical therapy and lifestyle intervention, metabolic surgery has shown superiority in achieving glycemic improvement, reducing number of medications and cardiovascular risk factors, which translates in long-term benefits on cardiovascular morbidity and mortality. The mechanisms underlying diabetes improvement after metabolic surgery have not yet been clearly understood but englobe a complex interaction among improvements in beta cell function and insulin secretion, insulin sensitivity, intestinal gluconeogenesis, changes in glucose utilization, and absorption by the gut and changes in the secretory pattern and morphology of adipose tissue. These are achieved through different mediators which include an enhancement in gut hormones release, especially, glucagon-like peptide 1, changes in bile acids circulation, gut microbiome, and glucose transporters expression. Therefore, this review aims to provide a comprehensive appraisal of what is known so far to better understand the mechanisms through which metabolic surgery improves glycemic control facilitating future research in the field.
AU  - Perez-Pevida,B
AU  - Escalada,J
AU  - Miras,AD
AU  - Fruhbeck,G
DO  - 10.3389/fendo.2019.00641
EP  - 9
PY  - 2019///
SN  - 1664-2392
SP  - 1
TI  - Mechanisms underlying Type 2 diabetes remission after metabolic surgery
T2  - Frontiers in Endocrinology
UR  - http://dx.doi.org/10.3389/fendo.2019.00641
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000487245100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2019.00641/full
UR  - http://hdl.handle.net/10044/1/82132
VL  - 10
ER  -
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