Imperial College London
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Dr Alex Miras

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7958 377 674a.miras

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sheridan:2021:10.1111/cob.12450,
author = {Sheridan, W and Da, Silva AS and Leca, BM and Ostarijas, E and Patel, AG and Aylwin, SJB and Vincent, RP and Panagiotopoulos, S and El-Hasani, S and le, Roux CW and Miras, AD and Cardozo, L and Dimitriadis, GK},
doi = {10.1111/cob.12450},
journal = {Clinical Obesity},
pages = {1--19},
title = {Weight loss with bariatric surgery or behaviour modification and the impact on female obesity-related urine incontinence: A comprehensive systematic review and meta-analysis},
url = {http://dx.doi.org/10.1111/cob.12450},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Women with obesity are at risk of pelvic floor dysfunction with a 3-fold increased incidence of urge urinary incontinence (UUI) and double the risk of stress urinary incontinence (SUI). The National Institute for Health and Care Excellence (NICE) and European Association of Urology (EAU) recommend that women with a body mass index ≥30 kg/m2 should consider weight loss prior to consideration for incontinence surgery. This systematic review and meta-analysis will assess this recommendation to aid in the counselling of women with obesity-related urinary incontinence (UI). Medical Literature Analysis and Retrieval System online (MEDLINE), EMBASE, Cochrane, ClinicalTrials.gov, and SCOPUS were systematically and critically appraised for all peer reviewed manuscripts that suitably fulfilled the inclusion criteria established a priori and presented original, empirical data relevant to weight loss intervention in the management of urinary incontinence. Thirty-three studies and their outcomes were meta-analysed. Weight loss interventions were associated in a decreased prevalence in UI (OR 0.222, 95% CI [0.147, 0.336]), SUI (OR 0.354, 95% CI [0.256, 0.489]), UUI (OR 0.437, 95% CI [0.295, 0.649]) and improved quality of life (PFDI-20, SMD -0.774 (95% CI [−1.236, −0.312]). This systematic review and meta-analysis provide evidence that weight loss interventions are effective in reducing the prevalence of obesity-related UI symptoms in women. Bariatric surgery in particular shows greater sustained weight loss and improvements in UI prevalence. Further large scale, randomized control trials assessing the effect of bariatric surgery on women with obesity-related UI are needed to confirm this study's findings.
AU  - Sheridan,W
AU  - Da,Silva AS
AU  - Leca,BM
AU  - Ostarijas,E
AU  - Patel,AG
AU  - Aylwin,SJB
AU  - Vincent,RP
AU  - Panagiotopoulos,S
AU  - El-Hasani,S
AU  - le,Roux CW
AU  - Miras,AD
AU  - Cardozo,L
AU  - Dimitriadis,GK
DO  - 10.1111/cob.12450
EP  - 19
PY  - 2021///
SN  - 1758-8103
SP  - 1
TI  - Weight loss with bariatric surgery or behaviour modification and the impact on female obesity-related urine incontinence: A comprehensive systematic review and meta-analysis
T2  - Clinical Obesity
UR  - http://dx.doi.org/10.1111/cob.12450
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000647461600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1111/cob.12450
UR  - http://hdl.handle.net/10044/1/89229
VL  - 11
ER  -
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