Imperial College London
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Dr Alex Miras

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7958 377 674a.miras

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Omran:2021:10.1177/20420188211066210,
author = {Omran, A and Leca, BM and Ostarijas, E and Graham, N and Da, Silva AS and Zair, ZM and Miras, AD and le, Roux CW and Vincent, RP and Cardozo, L and Dimitriadis, GK},
doi = {10.1177/20420188211066210},
journal = {Therapeutic Advances in Endocrinology and Metabolism},
pages = {1--39},
title = {Metabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors},
url = {http://dx.doi.org/10.1177/20420188211066210},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Metabolic syndrome (MetS) is defined by at least three of the following five criteria: blood pressure 130/85 mmHg, fasting blood glucose 5.6 mmol/l, triglycerides concentration 1.7 mmol/l, waist circumference 102 cm (for men), and high-density lipoprotein cholesterol concentration <1.03 mmol/l (for men). MetS has been associated with worse lower urinary tract symptoms (LUTS) and higher International Prostate Symptom questionnaire scores.Materials and Methods:MEDLINE, Cochrane, ClinicalTrials.gov, and SCOPUS were critically appraised for all peer-reviewed manuscripts that suitably fulfilled our protocol’s inclusion criteria established a priori. Meta-analytical and meta-regression calculations were performed in R using the Sidik–Jonkman and Hartung–Knapp random effects model and predefined covariates.Results:A total of 70 studies (n = 90,206) were included in qualitative synthesis. From these, 60 studies focused on MetS and LUTS: 44 reported positive correlations, 5 reported negative correlations, 11 reported no association, and 10 studies focused on MetS and total prostate volume (TPV). MetS positively correlated with moderate LUTS [odds ratio (OR)  = 1.56, 95% confidence interval (CI) = 1.35–1.80], severe LUTS (OR = 2.35, 95% CI = 1.82–3.03), overactive bladder (OAB; OR = 3.2, 95% CI = 1.6–5.8), and nocturia severity (OR = 2.509, 95% CI = 1.571–4.007) at multivariate analysis. A total of 30 studies (n = 22,206) were included in meta-analysis; MetS was significantly associated with higher TPV (mean differences = 4.4450 ml, 95% CI = 2.0177–6.8723), but no significant predictive factors for effect sizes were discovered.Conclusion:Our meta-analysis demonstrates a significant association between the
AU  - Omran,A
AU  - Leca,BM
AU  - Ostarijas,E
AU  - Graham,N
AU  - Da,Silva AS
AU  - Zair,ZM
AU  - Miras,AD
AU  - le,Roux CW
AU  - Vincent,RP
AU  - Cardozo,L
AU  - Dimitriadis,GK
DO  - 10.1177/20420188211066210
EP  - 39
PY  - 2021///
SN  - 2042-0188
SP  - 1
TI  - Metabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors
T2  - Therapeutic Advances in Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1177/20420188211066210
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000729489300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.sagepub.com/doi/10.1177/20420188211066210
UR  - http://hdl.handle.net/10044/1/93647
VL  - 12
ER  -
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