Imperial College London
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Dr Alex Miras

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7958 377 674a.miras

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Roser:2023:10.1530/ERC-22-0287,
author = {Roser, P and Leca, BM and Coelho, C and Schulte, K-M and Gilbert, J and Drakou, EE and Kosmas, C and Ling, Chuah L and Wassati, H and Miras, AD and Crane, J and Aylwin, SJB and Grossman, AB and Dimitriadis, GK},
doi = {10.1530/ERC-22-0287},
journal = {Endocrine-Related Cancer},
title = {Diagnosis and management of parathyroid carcinoma: a state-of-the-art review},
url = {http://dx.doi.org/10.1530/ERC-22-0287},
volume = {30},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Parathyroid carcinoma is one of the least common endocrine malignancies and accounts for approximately 1% of all patients with primary hyperparathyroidism. A systematic review of peer-reviewed literature published between January 2000 and March 2022 via Medline, Embase, Cochrane Central Register of Controlled Trials, EudraCT, ClinicalTrials.gov, CINAHL and SCOPUS was conducted. Manuscripts were eligible if they included data on adult non-pregnant populations with parathyroid carcinoma. No restrictions regarding interventions, comparators or duration of follow-up were imposed. Single case reports, reviews or meta-analyses were excluded. Outcomes of interest were molecular pathogenesis, clinical presentation, differential diagnosis, treatment, follow-up and overall survival. Study quality was evaluated using the Newcastle-Ottawa Scale for observational studies. This review included 75 studies from 17 countries, reporting on more than 3000 patients with parathyroid carcinoma. CDC73 mutation has been recognised as playing a pivotal role in molecular pathogenesis. Parathyroid carcinoma typically presents with markedly increased calcium and parathyroid hormone levels. The most frequently described symptoms were bone and muscle pain or weakness. En bloc resection remains the gold standard for the surgical approach. The 5-year overall survival ranged from 60 to 93%, with resistant hypercalcaemia a significant cause of mortality. Emerging evidence indicating that targeted therapy, based on molecular biomarkers, presents a novel treatment option. The rarity of PC and need for personalised treatment warrant multidisciplinary management in a 'centre of excellence' with a track record in PC management.
AU  - Roser,P
AU  - Leca,BM
AU  - Coelho,C
AU  - Schulte,K-M
AU  - Gilbert,J
AU  - Drakou,EE
AU  - Kosmas,C
AU  - Ling,Chuah L
AU  - Wassati,H
AU  - Miras,AD
AU  - Crane,J
AU  - Aylwin,SJB
AU  - Grossman,AB
AU  - Dimitriadis,GK
DO  - 10.1530/ERC-22-0287
PY  - 2023///
SN  - 1351-0088
TI  - Diagnosis and management of parathyroid carcinoma: a state-of-the-art review
T2  - Endocrine-Related Cancer
UR  - http://dx.doi.org/10.1530/ERC-22-0287
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36621911
UR  - http://hdl.handle.net/10044/1/104164
VL  - 30
ER  -
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