Publications
56 results found
Wood AR, Esko T, Yang J, et al., 2014, Defining the role of common variation in the genomic and biological architecture of adult human height, Nature Genetics, Vol: 46, Pages: 1173-1186, ISSN: 1546-1718
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate–related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
Moayyeri A, Hsu Y-H, Karasik D, et al., 2014, Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium, HUMAN MOLECULAR GENETICS, Vol: 23, Pages: 3054-3068, ISSN: 0964-6906
- Author Web Link
- Cite
- Citations: 68
Stegemann C, Pechlaner R, Willeit P, et al., 2014, Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-Based Bruneck Study, CIRCULATION, Vol: 129, Pages: 1821-1831, ISSN: 0009-7322
- Author Web Link
- Cite
- Citations: 297
Broer L, Codd V, Nyholt DR, et al., 2013, Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect, EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 21, Pages: 1163-1168, ISSN: 1018-4813
- Author Web Link
- Cite
- Citations: 283
Welch AA, MacGregor AJ, Skinner J, et al., 2013, A higher alkaline dietary load is associated with greater indexes of skeletal muscle mass in women, OSTEOPOROSIS INTERNATIONAL, Vol: 24, Pages: 1899-1908, ISSN: 0937-941X
- Author Web Link
- Cite
- Citations: 53
Cecelja M, Hussain T, Greil G, et al., 2013, Multimodality Imaging of Subclinical Aortic Atherosclerosis Relation of Aortic Stiffness to Calcification and Plaque in Female Twins, HYPERTENSION, Vol: 61, Pages: 609-614, ISSN: 0194-911X
- Author Web Link
- Cite
- Citations: 31
Moayyeri A, Hammond CJ, Valdes AM, et al., 2013, Cohort Profile: TwinsUK and Healthy Ageing Twin Study, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 42, Pages: 76-85, ISSN: 0300-5771
- Author Web Link
- Cite
- Citations: 161
Moayyeri A, Hammond CJ, Hart DJ, et al., 2013, The UK Adult Twin Registry (TwinsUK Resource), TWIN RESEARCH AND HUMAN GENETICS, Vol: 16, Pages: 144-149, ISSN: 1832-4274
- Author Web Link
- Cite
- Citations: 164
Moayyeri A, Hammond CJ, Hart DJ, et al., 2012, Effects of age on genetic influence on bone loss over 17 years in women: The Healthy Ageing Twin Study (HATS), JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 27, Pages: 2170-2178, ISSN: 0884-0431
- Author Web Link
- Cite
- Citations: 29
Livshits G, Malkin I, Moayyeri A, et al., 2012, Association of FTO gene variants with body composition in UK twins, ANNALS OF HUMAN GENETICS, Vol: 76, Pages: 333-341, ISSN: 0003-4800
- Author Web Link
- Cite
- Citations: 21
Moayyeri A, Luben RN, Wareham NJ, et al., 2012, Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study, JOURNAL OF INTERNAL MEDICINE, Vol: 271, Pages: 472-480, ISSN: 0954-6820
- Author Web Link
- Cite
- Citations: 32
Estrada K, Styrkarsdottir U, Evangelou E, et al., 2012, Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture, NATURE GENETICS, Vol: 44, Pages: 491-+, ISSN: 1061-4036
- Author Web Link
- Cite
- Citations: 799
Moayyeri A, Adams JE, Adler RA, et al., 2012, Quantitative ultrasound of the heel and fracture risk assessment: an updated meta-analysis, OSTEOPOROSIS INTERNATIONAL, Vol: 23, Pages: 143-153, ISSN: 0937-941X
- Author Web Link
- Cite
- Citations: 161
Lewiecki EM, Compston JE, Miller PD, et al., 2011, Official Positions for FRAX (R) Bone Mineral Density and FRAX (R) Simplification, JOURNAL OF CLINICAL DENSITOMETRY, Vol: 14, Pages: 226-236, ISSN: 1094-6950
- Author Web Link
- Cite
- Citations: 24
Moayyeri A, Soltani A, Moosapour H, et al., 2011, Evidence-based history taking under "time constraint", JOURNAL OF RESEARCH IN MEDICAL SCIENCES, Vol: 16, Pages: 559-564, ISSN: 1735-1995
- Author Web Link
- Cite
- Citations: 6
Moayyeri A, Alrawi YA, Myint PK, 2010, The complex mutual connection between stroke and bone health, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol: 503, Pages: 153-159, ISSN: 0003-9861
- Author Web Link
- Cite
- Citations: 4
Moayyeri A, Besson H, Luben RN, et al., 2010, The association between physical activity in different domains of life and risk of osteoporotic fractures, BONE, Vol: 47, Pages: 693-700, ISSN: 8756-3282
- Author Web Link
- Cite
- Citations: 23
Moayyeri A, 2009, The importance and applications of absolute fracture risk estimation in clinical practice and research, BONE, Vol: 45, Pages: 154-157, ISSN: 8756-3282
- Author Web Link
- Cite
- Citations: 2
Moayyeri A, Kaptoge S, Dalzell N, et al., 2009, The effect of including quantitative heel ultrasound in models for estimation of 10-year absolute risk of fracture, BONE, Vol: 45, Pages: 180-184, ISSN: 8756-3282
- Author Web Link
- Cite
- Citations: 20
Moayyeri A, Kaptoge S, Dalzell N, et al., 2009, Is QUS or DXA Better for Predicting the 10-Year Absolute Risk of Fracture?, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 24, Pages: 1319-1325, ISSN: 0884-0431
- Author Web Link
- Cite
- Citations: 55
Moayyeri A, Bingham SA, Luben RN, et al., 2009, Respiratory Function as a Marker of Bone Health and Fracture Risk in an Older Population, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 24, Pages: 956-963, ISSN: 0884-0431
- Author Web Link
- Cite
- Citations: 7
Moayyeri A, Kaptoge S, Luben RN, et al., 2009, Estimation of absolute fracture risk among middle-aged and older men and women: the EPIC-Norfolk population cohort study, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 24, Pages: 259-266, ISSN: 0393-2990
- Author Web Link
- Cite
- Citations: 11
Moayyeri A, 2009, Heel Ultrasound to Predict Fractures: How to Assess It and in Whom?, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 24, Pages: 558-559, ISSN: 0884-0431
Moayyeri A, 2009, Identification of Factors Influencing the Intervention Thresholds for Treatment of Osteoporosis Based on 10-Year Absolute Fracture Risks, JOURNAL OF CLINICAL DENSITOMETRY, Vol: 12, Pages: 1-4, ISSN: 1094-6950
Sadatsafavi M, Moayyeri A, Wang L, et al., 2008, Optimal decision criterion for detecting change in bone mineral density during serial monitoring: A Bayesian approach, OSTEOPOROSIS INTERNATIONAL, Vol: 19, Pages: 1589-1596, ISSN: 0937-941X
- Author Web Link
- Cite
- Citations: 4
Sadatsafavi M, Moayyeri A, Wang L, et al., 2008, Heteroscedastic Regression Analysis of Factors Affecting BMD Monitoring, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 23, Pages: 1842-1849, ISSN: 0884-0431
- Author Web Link
- Cite
- Citations: 3
Moayyeri A, 2008, The Association Between Physical Activity and Osteoporotic Fractures: A Review of the Evidence and Implications for Future Research, ANNALS OF EPIDEMIOLOGY, Vol: 18, Pages: 827-835, ISSN: 1047-2797
- Author Web Link
- Cite
- Citations: 161
Moayyeri A, 2008, Comment on Kanis et al.: The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women, OSTEOPOROSIS INTERNATIONAL, Vol: 19, Pages: 591-592, ISSN: 0937-941X
- Author Web Link
- Cite
- Citations: 1
Moayyeri A, Luben RN, Bingham SA, et al., 2008, Measured height loss predicts fractures in middle-aged and older men and women: The EPIC-Norfolk prospective population study, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 23, Pages: 425-432, ISSN: 0884-0431
- Author Web Link
- Cite
- Citations: 35
Soltani A, Hasani-Ranjbar S, Moayyeri A, 2008, Hypocalcemia as a presentation for multifocal osteosarcoma, PEDIATRIC BLOOD & CANCER, Vol: 50, Pages: 687-689, ISSN: 1545-5009
- Author Web Link
- Cite
- Citations: 4
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.