Imperial College London
Alternate

DrAlirezaMoayyeri

Faculty of Medicine, School of Public Health

Honorary Research Associate
 
 
 
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a.moayyeri Website CV

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
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56 results found

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chun AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Maegi R, Mihailov E, Porcu E, Randall JC, Scherag A, Vinkhuyzen AAE, Westra H-J, Winkler TW, Workalemahu T, Zhao JH, Absher D, Albrecht E, Anderson D, Baron J, Beekman M, Demirkan A, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Fraser RM, Goel A, Gong J, Justice AE, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Lui JC, Mangino M, Leach IM, Medina-Gomez C, Nalls MA, Nyholt DR, Palmer CD, Pasko D, Pechlivanis S, Prokopenko I, Ried JS, Ripke S, Shungin D, Stancakova A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Afzal U, Arnloev J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blueher M, Bolton JL, Boettcher Y, Boyd HA, Bruinenberg M, Buckley BM, Buyske S, Caspersen IH, Chines PS, Clarke R, Claudi-Boehm S, Cooper M, Daw EW, De Jong PA, Deelen J, Delgado G, Denny JC, Dhonukshe-Rutten R, Dimitriou M, Doney ASF, Doerr M, Eklund N, Eury E, Folkersen L, Garcia ME, Geller F, Giedraitis V, Go AS, Grallert H, Grammer TB, Graessler J, Groenberg H, de Groot LCPGM, Groves CJ, Haessler J, Hall P, Haller T, Hallmans G, Hannemann A, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hemani G, Henders AK, Hillege HL, Hlatky MA, Hoffmann W, Hoffmann P, Holmen O, Houwing-Duistermaat JJ, Illig T, Isaacs A, James AL, Jeff J, Johansen B, Johansson A, Jolley J, Juliusdottir T, Junttila J, Kho AN, Kinnunen L, Klopp N, Kocher T, Kratzer W, Lichtner P, Lind L, Lindstroem J, Lobbens S, Lorentzon M, Lu Y, Lyssenko V, Magnusson PKE, Mahajan A, Maillard M, McArdle WL, McKenzie CA, McLachlan S, McLaren PJ, Menni C, Merger S, Milani L, Moayyeri A, Monda KL, Morken MA, Mueller G, Mueller-Nurasyid M, Musk AW, Narisu N, Nauck M, Nolte IM, Noet al., 2014, Defining the role of common variation in the genomic and biological architecture of adult human height, Nature Genetics, Vol: 46, Pages: 1173-1186, ISSN: 1546-1718

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate–related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

Journal article

Moayyeri A, Hsu Y-H, Karasik D, Estrada K, Xiao S-M, Nielson C, Srikanth P, Giroux S, Wilson SG, Zheng H-F, Smith AV, Pye SR, Leo PJ, Teumer A, Hwang J-Y, Ohlsson C, McGuigan F, Minster RL, Hayward C, Olmos JM, Lyytikaeinen L-P, Lewis JR, Swart KMA, Masi L, Oldmeadow C, Holliday EG, Cheng S, van Schoor NM, Harvey NC, Kruk M, Fabiola Del Greco M, Igl W, Trummer O, Grigoriou E, Luben R, Liu C-T, Zhou Y, Oei L, Medina-Gomez C, Zmuda J, Tranah G, Brown SJ, Williams FM, Soranzo N, Jakobsdottir J, Siggeirsdottir K, Holliday KL, Hannemann A, Go MJ, Garcia M, Polasek O, Laaksonen M, Zhu K, Enneman AW, McEvoy M, Peel R, Sham PC, Jaworski M, Johansson A, Hicks AA, Pludowski P, Scott R, Dhonukshe-Rutten RAM, van der Velde N, Kaehoenen M, Viikari JS, Sievaenen H, Raitakari OT, Gonzalez-Macias J, Hernandez JL, Mellstroem D, Ljunggren O, Cho YS, Voelker U, Nauck M, Homuth G, Voelzke H, Haring R, Brown MA, McCloskey E, Nicholson GC, Eastell R, Eisman JA, Jones G, Reid IR, Dennison EM, Wark J, Boonen S, Vanderschueren D, Wu FCW, Aspelund T, Richards JB, Bauer D, Hofman A, Khaw K-T, Dedoussis G, Obermayer-Pietsch B, Gyllensten U, Pramstaller PP, Lorenc RS, Cooper C, Kung AWC, Lips P, Alen M, Attia J, Luisa Brandi M, de Groot LCPGM, Lehtimaeki T, Riancho JA, Campbell H, Liu Y, Harris TB, Akesson K, Karlsson M, Lee J-Y, Wallaschofski H, Duncan EL, O'Neill TW, Gudnason V, Spector TD, Rousseau F, Orwoll E, Cummings SR, Wareham NJ, Rivadeneira F, Uitterlinden AG, Prince RL, Kiel DP, Reeve J, Kaptoge SKet al., 2014, Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium, HUMAN MOLECULAR GENETICS, Vol: 23, Pages: 3054-3068, ISSN: 0964-6906

Journal article

Stegemann C, Pechlaner R, Willeit P, Langley SR, Mangino M, Mayr U, Menni C, Moayyeri A, Santer P, Rungger G, Spector TD, Willeit J, Kiechl S, Mayr Met al., 2014, Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-Based Bruneck Study, CIRCULATION, Vol: 129, Pages: 1821-1831, ISSN: 0009-7322

Journal article

Broer L, Codd V, Nyholt DR, Deelen J, Mangino M, Willemsen G, Albrecht E, Amin N, Beekman M, de Geus EJC, Henders A, Nelson CP, Steves CJ, Wright MJ, de Craen AJM, Isaacs A, Matthews M, Moayyeri A, Montgomery GW, Oostra BA, Vink JM, Spector TD, Slagboom PE, Martin NG, Samani NJ, van Duijn CM, Boomsma DIet al., 2013, Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect, EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 21, Pages: 1163-1168, ISSN: 1018-4813

Journal article

Welch AA, MacGregor AJ, Skinner J, Spector TD, Moayyeri A, Cassidy Aet al., 2013, A higher alkaline dietary load is associated with greater indexes of skeletal muscle mass in women, OSTEOPOROSIS INTERNATIONAL, Vol: 24, Pages: 1899-1908, ISSN: 0937-941X

Journal article

Cecelja M, Hussain T, Greil G, Botnar R, Preston R, Moayyeri A, Spector TD, Chowienczyk Pet al., 2013, Multimodality Imaging of Subclinical Aortic Atherosclerosis Relation of Aortic Stiffness to Calcification and Plaque in Female Twins, HYPERTENSION, Vol: 61, Pages: 609-614, ISSN: 0194-911X

Journal article

Moayyeri A, Hammond CJ, Valdes AM, Spector TDet al., 2013, Cohort Profile: TwinsUK and Healthy Ageing Twin Study, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 42, Pages: 76-85, ISSN: 0300-5771

Journal article

Moayyeri A, Hammond CJ, Hart DJ, Spector TDet al., 2013, The UK Adult Twin Registry (TwinsUK Resource), TWIN RESEARCH AND HUMAN GENETICS, Vol: 16, Pages: 144-149, ISSN: 1832-4274

Journal article

Moayyeri A, Hammond CJ, Hart DJ, Spector TDet al., 2012, Effects of age on genetic influence on bone loss over 17 years in women: The Healthy Ageing Twin Study (HATS), JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 27, Pages: 2170-2178, ISSN: 0884-0431

Journal article

Livshits G, Malkin I, Moayyeri A, Spector TD, Hammond CJet al., 2012, Association of FTO gene variants with body composition in UK twins, ANNALS OF HUMAN GENETICS, Vol: 76, Pages: 333-341, ISSN: 0003-4800

Journal article

Moayyeri A, Luben RN, Wareham NJ, Khaw K-Tet al., 2012, Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study, JOURNAL OF INTERNAL MEDICINE, Vol: 271, Pages: 472-480, ISSN: 0954-6820

Journal article

Estrada K, Styrkarsdottir U, Evangelou E, Hsu Y-H, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, Koller DL, Li G, Liu C-T, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao S-M, Yerges-Armstrong LM, Zheng H-F, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, Gonzalez-Macias J, Kahonen M, Karlsson M, Khusnutdinova E, Koh J-M, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren O, Lorenc RS, Marc J, Mellstrom D, Obermayer-Pietsch B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau F, Slagboom PE, Tang NLS, Urreizti R, Van Hul W, Viikari J, Zarrabeitia MT, Aulchenko YS, Castano-Betancourt M, Grundberg E, Herrera L, Ingvarsson T, Johannsdottir H, Kwan T, Li R, Luben R, Medina-Gomez C, Palsson ST, Reppe S, Rotter JI, Sigurdsson G, van Meurs JBJ, Verlaan D, Williams FMK, Wood AR, Zhou Y, Gautvik KM, Pastinen T, Raychaudhuri S, Cauley JA, Chasman DI, Clark GR, Cummings SR, Danoy P, Dennison EM, Eastell R, Eisman JA, Gudnason V, Hofman A, Jackson RD, Jones G, Jukema JW, Khaw K-T, Lehtimaki T, Liu Y, Lorentzon M, McCloskey E, Mitchell BD, Nandakumar K, Nicholson GC, Oostra BA, Peacock M, Pols HAP, Prince RL, Raitakari O, Reid IR, Robbins J, Sambrook PN, Sham PC, Shuldiner AR, Tylavsky FA, van Duijn CM, Wareham NJ, Cupples LA, Econs MJ, Evans DM, Harris TB, Kung AWC, Psaty BM, Reeve J, Spector TD, Streeten EA, Zillikens MC, Thorsteinsdottir U, Ohlet al., 2012, Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture, NATURE GENETICS, Vol: 44, Pages: 491-+, ISSN: 1061-4036

Journal article

Moayyeri A, Adams JE, Adler RA, Krieg M-A, Hans D, Compston J, Lewiecki EMet al., 2012, Quantitative ultrasound of the heel and fracture risk assessment: an updated meta-analysis, OSTEOPOROSIS INTERNATIONAL, Vol: 23, Pages: 143-153, ISSN: 0937-941X

Journal article

Lewiecki EM, Compston JE, Miller PD, Adachi JD, Adams JE, Leslie WD, Kanis JA, Moayyeri A, Adler RA, Hans DB, Kendler DL, Diez-Perez A, Krieg M-A, Masri BK, Lorenc RR, Bauer DC, Blake GM, Josse RG, Clark P, Khan AAet al., 2011, Official Positions for FRAX (R) Bone Mineral Density and FRAX (R) Simplification, JOURNAL OF CLINICAL DENSITOMETRY, Vol: 14, Pages: 226-236, ISSN: 1094-6950

Journal article

Moayyeri A, Soltani A, Moosapour H, Raza Met al., 2011, Evidence-based history taking under "time constraint", JOURNAL OF RESEARCH IN MEDICAL SCIENCES, Vol: 16, Pages: 559-564, ISSN: 1735-1995

Journal article

Moayyeri A, Alrawi YA, Myint PK, 2010, The complex mutual connection between stroke and bone health, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol: 503, Pages: 153-159, ISSN: 0003-9861

Journal article

Moayyeri A, Besson H, Luben RN, Wareham NJ, Khaw K-Tet al., 2010, The association between physical activity in different domains of life and risk of osteoporotic fractures, BONE, Vol: 47, Pages: 693-700, ISSN: 8756-3282

Journal article

Moayyeri A, 2009, The importance and applications of absolute fracture risk estimation in clinical practice and research, BONE, Vol: 45, Pages: 154-157, ISSN: 8756-3282

Journal article

Moayyeri A, Kaptoge S, Dalzell N, Luben RN, Wareham NJ, Bingham S, Reeve J, Khaw KTet al., 2009, The effect of including quantitative heel ultrasound in models for estimation of 10-year absolute risk of fracture, BONE, Vol: 45, Pages: 180-184, ISSN: 8756-3282

Journal article

Moayyeri A, Kaptoge S, Dalzell N, Bingham S, Luben RN, Wareham NJ, Reeve J, Khaw KTet al., 2009, Is QUS or DXA Better for Predicting the 10-Year Absolute Risk of Fracture?, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 24, Pages: 1319-1325, ISSN: 0884-0431

Journal article

Moayyeri A, Bingham SA, Luben RN, Wareham NJ, Khaw K-Tet al., 2009, Respiratory Function as a Marker of Bone Health and Fracture Risk in an Older Population, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 24, Pages: 956-963, ISSN: 0884-0431

Journal article

Moayyeri A, Kaptoge S, Luben RN, Wareham NJ, Bingham S, Reeve J, Khaw KTet al., 2009, Estimation of absolute fracture risk among middle-aged and older men and women: the EPIC-Norfolk population cohort study, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 24, Pages: 259-266, ISSN: 0393-2990

Journal article

Moayyeri A, 2009, Heel Ultrasound to Predict Fractures: How to Assess It and in Whom?, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 24, Pages: 558-559, ISSN: 0884-0431

Journal article

Moayyeri A, 2009, Identification of Factors Influencing the Intervention Thresholds for Treatment of Osteoporosis Based on 10-Year Absolute Fracture Risks, JOURNAL OF CLINICAL DENSITOMETRY, Vol: 12, Pages: 1-4, ISSN: 1094-6950

Journal article

Sadatsafavi M, Moayyeri A, Wang L, Leslie WDet al., 2008, Optimal decision criterion for detecting change in bone mineral density during serial monitoring: A Bayesian approach, OSTEOPOROSIS INTERNATIONAL, Vol: 19, Pages: 1589-1596, ISSN: 0937-941X

Journal article

Sadatsafavi M, Moayyeri A, Wang L, Leslie WDet al., 2008, Heteroscedastic Regression Analysis of Factors Affecting BMD Monitoring, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 23, Pages: 1842-1849, ISSN: 0884-0431

Journal article

Moayyeri A, 2008, The Association Between Physical Activity and Osteoporotic Fractures: A Review of the Evidence and Implications for Future Research, ANNALS OF EPIDEMIOLOGY, Vol: 18, Pages: 827-835, ISSN: 1047-2797

Journal article

Moayyeri A, 2008, Comment on Kanis et al.: The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women, OSTEOPOROSIS INTERNATIONAL, Vol: 19, Pages: 591-592, ISSN: 0937-941X

Journal article

Moayyeri A, Luben RN, Bingham SA, Welch AA, Wareham NJ, Khaw K-Tet al., 2008, Measured height loss predicts fractures in middle-aged and older men and women: The EPIC-Norfolk prospective population study, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 23, Pages: 425-432, ISSN: 0884-0431

Journal article

Soltani A, Hasani-Ranjbar S, Moayyeri A, 2008, Hypocalcemia as a presentation for multifocal osteosarcoma, PEDIATRIC BLOOD & CANCER, Vol: 50, Pages: 687-689, ISSN: 1545-5009

Journal article

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