Imperial College London
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Dr. Anna C. Need

Faculty of Medicine, Department of Brain Sciences

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8436a.need Website

 
 
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Location

 

7N2aCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lam:2017:10.1016/j.celrep.2017.11.028,
author = {Lam, M and Trampush, JW and Yu, J and Knowles, E and Davies, G and Liewald, DC and Starr, JM and Djurovic, S and Melle, I and Sundet, K and Christoforou, A and Reinvang, I and DeRosse, P and Lundervold, AJ and Steen, VM and Espeseth, T and Räikkönen, K and Widen, E and Palotie, A and Eriksson, JG and Giegling, I and Konte, B and Roussos, P and Giakoumaki, S and Burdick, KE and Payton, A and Ollier, W and Chiba-Falek, O and Attix, DK and Need, AC and Cirulli, ET and Voineskos, AN and Stefanis, NC and Avramopoulos, D and Hatzimanolis, A and Arking, DE and Smyrnis, N and Bilder, RM and Freimer, NA and Cannon, TD and London, E and Poldrack, RA and Sabb, FW and Congdon, E and Conley, ED and Scult, MA and Dickinson, D and Straub, RE and Donohoe, G and Morris, D and Corvin, A and Gill, M and Hariri, AR and Weinberger, DR and Pendleton, N and Bitsios, P and Rujescu, D and Lahti, J and Le, Hellard S and Keller, MC and Andreassen, OA and Deary, IJ and Glahn, DC and Malhotra, AK and Lencz, T},
doi = {10.1016/j.celrep.2017.11.028},
journal = {Cell Reports},
pages = {2597--2613},
title = {Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets.},
url = {http://dx.doi.org/10.1016/j.celrep.2017.11.028},
volume = {21},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Here, we present a large (n = 107,207) genome-wide association study (GWAS) of general cognitive ability ("g"), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified 70 independent genomic loci associated with general cognitive ability. Results showed significant enrichment for genes causing Mendelian disorders with an intellectual disability phenotype. Competitive pathway analysis implicated the biological processes of neurogenesis and synaptic regulation, as well as the gene targets of two pharmacologic agents: cinnarizine, a T-type calcium channel blocker, and LY97241, a potassium channel inhibitor. Transcriptome-wide and epigenome-wide analysis revealed that the implicated loci were enriched for genes expressed across all brain regions (most strongly in the cerebellum). Enrichment was exclusive to genes expressed in neurons but not oligodendrocytes or astrocytes. Finally, we report genetic correlations between cognitive ability and disparate phenotypes including psychiatric disorders, several autoimmune disorders, longevity, and maternal age at first birth.
AU  - Lam,M
AU  - Trampush,JW
AU  - Yu,J
AU  - Knowles,E
AU  - Davies,G
AU  - Liewald,DC
AU  - Starr,JM
AU  - Djurovic,S
AU  - Melle,I
AU  - Sundet,K
AU  - Christoforou,A
AU  - Reinvang,I
AU  - DeRosse,P
AU  - Lundervold,AJ
AU  - Steen,VM
AU  - Espeseth,T
AU  - Räikkönen,K
AU  - Widen,E
AU  - Palotie,A
AU  - Eriksson,JG
AU  - Giegling,I
AU  - Konte,B
AU  - Roussos,P
AU  - Giakoumaki,S
AU  - Burdick,KE
AU  - Payton,A
AU  - Ollier,W
AU  - Chiba-Falek,O
AU  - Attix,DK
AU  - Need,AC
AU  - Cirulli,ET
AU  - Voineskos,AN
AU  - Stefanis,NC
AU  - Avramopoulos,D
AU  - Hatzimanolis,A
AU  - Arking,DE
AU  - Smyrnis,N
AU  - Bilder,RM
AU  - Freimer,NA
AU  - Cannon,TD
AU  - London,E
AU  - Poldrack,RA
AU  - Sabb,FW
AU  - Congdon,E
AU  - Conley,ED
AU  - Scult,MA
AU  - Dickinson,D
AU  - Straub,RE
AU  - Donohoe,G
AU  - Morris,D
AU  - Corvin,A
AU  - Gill,M
AU  - Hariri,AR
AU  - Weinberger,DR
AU  - Pendleton,N
AU  - Bitsios,P
AU  - Rujescu,D
AU  - Lahti,J
AU  - Le,Hellard S
AU  - Keller,MC
AU  - Andreassen,OA
AU  - Deary,IJ
AU  - Glahn,DC
AU  - Malhotra,AK
AU  - Lencz,T
DO  - 10.1016/j.celrep.2017.11.028
EP  - 2613
PY  - 2017///
SN  - 2211-1247
SP  - 2597
TI  - Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets.
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2017.11.028
UR  - http://hdl.handle.net/10044/1/54488
VL  - 21
ER  -
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