Publications
124 results found
Danks JM, Cromwell O, Buckingham JA, et al., 1981, Toluene-diisocyanate induced asthma: evaluation of antibodies in the serum of affected workers against a tolyl mono-isocyanate protein conjugate., Clin Allergy, Vol: 11, Pages: 161-168, ISSN: 0009-9090
Radioallergosorbent testing was used to look for the presence of specific IgE antibody against a para-tolyl-mono-isocyanate human serum albumin conjugate in sera from five groups of subjects. The first three groups consisted of individuals exposed to toluene diisocyanate (TDI) who had been shown by bronchial provocation testing with levels of TDI below the threshold limit value of 0.02 parts/10(6), to have immediate asthmatic reactions, late asthmatic reactions or no respiratory changes at all. The two control groups consisted of atopic and non-atopic individuals who had no respiratory symptoms and no known exposure to TDI. Although RAST showed high ct/min in some of the sera from patients with proven TDI-induced respiratory disease, these levels were not significantly different from controls and appeared to reflect the presence in these sera of high levels of total IgE (greater than 100 mu ml--1). There is no evidence from this study for the presence of specific IgE antibody against a para-tolyl mono isocyanate human serum albumin conjugate in patients with TDI-induced respiratory disease. This finding may reflect absence of antibodies, or that the techniques for their detection are not always effective even when performed by experienced persons, and there is a potential source of error in the interpretation of results when sera contain large amounts of IgE.
Newman Taylor AJ, 1980, Occupational asthma., Thorax, Vol: 35, Pages: 241-245, ISSN: 0040-6376
O'Brien IM, Newman-Taylor AJ, Burge PS, et al., 1979, Toluene di-isocyanate-induced asthma. II. Inhalation challenge tests and bronchial reactivity studies., Clin Allergy, Vol: 9, Pages: 7-15, ISSN: 0009-9090
In sixty-three workers exposed to toluene di-isocyanate (TDI), no overall differences in bronchial reactivity to histamine inhalation and to exercise testing were found between the total groups of positive and negative TDI reactors to provocation tests. A subgroup of TDI highly sensitive subjects reacting to very low concentrations (less than or equal to 0.001 p.p.m.) were more sensitive to both histamine and exercise than the group who were less sensitive to TDI, and who reacted to higher concentrations (0.002--0.02 p.p.m.) than the group of non-reactors. There were, however, in the last group a number of subjects with high degrees of histamine reactivity who did not react to the TDI. These findings suggest that, on the one hand, the asthmatic reactions to TDI cannot be attributed solely to non-specific mechanisms and, on the other, that in subjects with high degrees of specific sensitivity non-specific mechanisms may also be playing a part.
Hedges A, Maclay WP, Newman-Taylor AJ, et al., 1971, Some central and peripheral effects of meclastine, a new antihistaminic drug, in man., J Clin Pharmacol New Drugs, Vol: 11, Pages: 112-119, ISSN: 0021-9754
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