DrAnkeNijhuis

Faculty of Medicine, Department of Surgery & Cancer

Research Fellow

Contact

Location

Institute of Reproductive and Developmental BiologyHammersmith Campus

Summary

Anke is a Research Fellow and Group Leader within the Division of Cancer at Imperial College London. Her research aims to understand how alternative RNA splicing contributes to cancer and identify targets to develop new therapeutics.

Her work currently focuses on small molecular glue protein degraders such as aryl sulfonamide that deplete RNA splicing factor, RBM39. Through integrative multi-omic analyses she aims to understand how targeting RNA splicing can be utilized for therapeutic intervention or improve current clinical agents with rationale drug combination strategies.

Anke received her PhD from Queen Mary University of London (2015) where she worked in Prof. Silver’s team on post-transcriptional regulation of non-coding RNAs (microRNAs) in cancer and inflammatory bowel disease.

Current funding

Research Fellowship (NIHR Imperial BRC & AstraZeneca)
Project Grants (Ovarian Cancer Action, NIHR Imperial BRC)
PhD studentships (Imperial College London President's Scholarship, CSC, CRUK Convergence Science Centre)

Selected Publications

Journal Articles

Mehta SJ, Lewis A, Nijhuis A, et al.Mehta SJ, Lewis A, Nijhuis A, Jeffery R, Biancheri P, Di Sabatino A, Feakins R, Silver A, Lindsay JO close, 2018, Epithelial down‐regulation of the miR‐200 family in fibrostenosing Crohn's disease is associated with features of epithelial to mesenchymal transition, Journal of Cellular and Molecular Medicine, Vol:22, ISSN:1582-1838, Pages:5617-5628

Bustos V, Nolan ÁM, Nijhuis A, et al.Bustos V, Nolan ÁM, Nijhuis A, Harvey H, Parker A, Poulsom R, McBryan J, Thomas W, Silver A, Harvey BJ close, 2017, GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions, Oncotarget, Vol:8, Pages:84258-84275

Nijhuis A, Curciarello R, Mehta S, et al.Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO, Silver A close, 2017, MCL-1 is modulated in Crohn’s disease fibrosis by miR-29b via IL-6 and IL-8, Cell and Tissue Research, Vol:368, ISSN:0302-766X, Pages:325-335

Nijhuis A, Thompson H, Adam J, et al.Nijhuis A, Thompson H, Adam J, Parker A, Gammon L, Lewis A, Bundy JG, Soga T, Jalaly A, Propper D, Jeffery R, Suraweera N, McDonald S, Thaha MA, Feakins R, Lowe R, Bishop CL, Silver A close, 2017, Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance, Human Molecular Genetics, Vol:26, ISSN:0964-6906, Pages:1552-1564

Nijhuis A, Biancheri P, Lewis A, et al.Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R, Di Sabatino A, Corazza GR, MacDonald TT, Lindsay JO, Silver AR close, 2014, In Crohn's disease fibrosis-reduced expression of the <i>miR-29</i> family enhances collagen expression in intestinal fibroblasts, Clinical Science, Vol:127, ISSN:0143-5221, Pages:341-350

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