Alexi completed his PhD at University College London investigating the function of epigenetic regulators during brain development. During his postdoctoral fellowship at MIT he investigated the role of epigenetics in postnatal development and autism-related behaviors. His research at the University of California, San Diego examined epigenetic mechanisms underlying age-related brain disorders and he identified microglia as associated with the genetic risk of Alzheimer’s disease.
Alexi's group utilizes nuclei isolation methods and genome-wide sequencing approaches to examine the epigenome of brain cell types using patient-derived archived tissue. Functional interrogation of disease-associated gene regulatory regions will employ CRISPR DNA-editing technology of pluripotent stem cells derived into brain cell types. Using a combination of these approaches, Alexi will examine the epigenome of the human brain to understand how genetic variation contributes to age-related brain disorders.
Nott A, Holtman IR, 2023, Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease, Frontiers in Immunology, Vol:14, ISSN:1664-3224, Pages:1-15
Murphy KB, Nott A, Marzi SJ, 2021, CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of brain disorders
et al., 2021, Nuclei isolation of multiple brain cell types for omics interrogation, Nature Protocols, Vol:16, ISSN:1754-2189, Pages:1629-1646
et al., 2019, Brain cell type-specific enhancer-promoter interactome maps and disease-risk association, Science, Vol:366, ISSN:0036-8075, Pages:1134-1139
Nott A, Glass CK, 2018, Immune memory in the brain, Nature, Vol:556, ISSN:0028-0836, Pages:312-313
et al., 2016, Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior, Nature Neuroscience, Vol:19, ISSN:1097-6256, Pages:1497-1505
et al., 2016, S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration, Proceedings of the National Academy of Sciences of the United States of America, Vol:113, ISSN:0027-8424, Pages:4152-4157
et al., 2015, HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex., Neuroepigenetics, Vol:1, ISSN:2214-7845, Pages:34-40
et al., 2013, S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration., Proc Natl Acad Sci U S A, Vol:110, Pages:3113-3118
Nott A, Riccio A, 2009, Nitric oxide-mediated epigenetic mechanisms in developing neurons, Cell Cycle, Vol:8, ISSN:1538-4101, Pages:725-730
et al., 2008, S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons, Nature, Vol:455, ISSN:0028-0836, Pages:411-U67