Imperial College London
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DrAlexiNott

Faculty of Medicine, Department of Brain Sciences

Lecturer in Neurogenomics, UK DRI Group Leader
 
 
 
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Contact

 

a.nott Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nott:2015:10.1016/j.nepig.2014.10.005,
author = {Nott, A and Cho, S and Seo, J and Tsai, L-H},
doi = {10.1016/j.nepig.2014.10.005},
journal = {Neuroepigenetics},
pages = {34--40},
title = {HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex.},
url = {http://dx.doi.org/10.1016/j.nepig.2014.10.005},
volume = {1},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - An experience-dependent postnatal increase in GABAergic inhibition in the visual cortex is important for the closure of a critical period of enhanced synaptic plasticity. Although maturation of the subclass of Parvalbumin (Pv)-expressing GABAergic interneurons is known to contribute to critical period closure, the role of epigenetics on cortical inhibition and synaptic plasticity has not been explored. The transcription regulator, histone deacetylase 2 (HDAC2), has been shown to modulate synaptic plasticity and learning processes in hippocampal excitatory neurons. We found that genetic deletion of HDAC2 specifically from Pv-interneurons reduces inhibitory input in the visual cortex of adult mice, and coincides with enhanced long-term depression (LTD) that is more typical of young mice. These findings show that HDAC2 loss in Pv-interneurons leads to a delayed closure of the critical period in the visual cortex and supports the hypothesis that HDAC2 is a key negative regulator of synaptic plasticity in the adult brain.
AU  - Nott,A
AU  - Cho,S
AU  - Seo,J
AU  - Tsai,L-H
DO  - 10.1016/j.nepig.2014.10.005
EP  - 40
PY  - 2015///
SN  - 2214-7845
SP  - 34
TI  - HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex.
T2  - Neuroepigenetics
UR  - http://dx.doi.org/10.1016/j.nepig.2014.10.005
UR  - https://www.ncbi.nlm.nih.gov/pubmed/25705589
VL  - 1
ER  -
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