Imperial College London
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DrAlexiNott

Faculty of Medicine, Department of Brain Sciences

Lecturer in Neurogenomics, UK DRI Group Leader
 
 
 
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Contact

 

a.nott Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nott:2013:10.1073/pnas.1218126110,
author = {Nott, A and Nitarska, J and Veenvliet, JV and Schacke, S and Derijck, AAHA and Sirko, P and Muchardt, C and Pasterkamp, RJ and Smidt, MP and Riccio, A},
doi = {10.1073/pnas.1218126110},
journal = {Proc Natl Acad Sci U S A},
pages = {3113--3118},
title = {S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration.},
url = {http://dx.doi.org/10.1073/pnas.1218126110},
volume = {110},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.
AU  - Nott,A
AU  - Nitarska,J
AU  - Veenvliet,JV
AU  - Schacke,S
AU  - Derijck,AAHA
AU  - Sirko,P
AU  - Muchardt,C
AU  - Pasterkamp,RJ
AU  - Smidt,MP
AU  - Riccio,A
DO  - 10.1073/pnas.1218126110
EP  - 3118
PY  - 2013///
SP  - 3113
TI  - S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration.
T2  - Proc Natl Acad Sci U S A
UR  - http://dx.doi.org/10.1073/pnas.1218126110
UR  - https://www.ncbi.nlm.nih.gov/pubmed/23359715
VL  - 110
ER  -
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