Publications
268 results found
Howes A, Stimpson P, Redford P, et al., 2014, Interleukin-10: Cytokines in anti- inflammation and tolerance, Cytokine Frontiers: Regulation of Immune Responses in Health and Disease, Pages: 327-352, ISBN: 9784431544418
Interleukin (IL)-10 is an immunosuppressive cytokine produced by many cells of the innate and adaptive immune response, including macrophages, dendritic cells, B cells, and T cells. A major role of IL-10 is to act as a feedback regulator of the immune response by inhibiting the production of inflammatory cytokines by innate cells such as macrophages and dendritic cells. Thus, the production of IL-10 in response to microbial flora is required to inhibit the development of colitis and, during infection, to inhibit an over-exuberant immune response that may potentially result in morbidity and mortality to the host. Thus, appropriate levels of IL-10 should be induced to inhibit host damage, but not to the level that they inhibit a protective immune response to a pathogen which could result in chronic infection. Regulation of the immune response by IL-10 has been shown to play a role in control of allergic, inflammatory, and autoimmune diseases, and further knowledge may advance our ability to use antagonists or agonists of IL-10 for immune therapies.
Fillatreau S, O'Garra A, 2014, Interleukin-10 in Health and Disease Preface, INTERLEUKIN-10 IN HEALTH AND DISEASE, Editors: Fillatreau, OGarra, Publisher: SPRINGER-VERLAG BERLIN, Pages: V-V, ISBN: 978-3-662-43491-8
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- Citations: 3
Esmail H, Lai P, Graham CM, et al., 2014, Characterisation Of A Whole Blood Transcriptional Signature Of Subclinical Tuberculosis Identified By Fdg-Pet/ct In Asymptomatic Hiv-1 Infected Adults, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
Howes A, Gabryšová L, O'Garra A, 2014, Role of IL-10 and the IL-10 Receptor in Immune Responses, Reference Module in Biomedical Sciences, Publisher: Elsevier
Gabrysova L, Howes A, Saraiva M, et al., 2014, The Regulation of IL-10 Expression, INTERLEUKIN-10 IN HEALTH AND DISEASE, Vol: 380, Pages: 157-190, ISSN: 0070-217X
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- Citations: 134
Berry MPR, Blankley S, Graham CM, et al., 2013, Systems approaches to studying the immune response in tuberculosis, CURRENT OPINION IN IMMUNOLOGY, Vol: 25, Pages: 579-587, ISSN: 0952-7915
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- Citations: 28
McNab FW, Ewbank J, Rajsbaum R, et al., 2013, TPL-2-ERK1/2 Signaling Promotes Host Resistance against Intracellular Bacterial Infection by Negative Regulation of Type I IFN Production, JOURNAL OF IMMUNOLOGY, Vol: 191, Pages: 1732-1743, ISSN: 0022-1767
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- Citations: 65
Bloom CI, Graham CM, Berry MPR, et al., 2013, Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 222
Pitt JM, Blankley S, McShane H, et al., 2013, Vaccination against tuberculosis: How can we better BCG?, MICROBIAL PATHOGENESIS, Vol: 58, Pages: 2-16, ISSN: 0882-4010
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- Citations: 54
O'Garra A, 2013, Brigitte Askonas (<i>1923</i>-<i>2013</i>) OBITUARY, NATURE, Vol: 494, Pages: 37-37, ISSN: 0028-0836
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- Citations: 4
O'Garra A, 2013, Driving change in tuberculosis research: an interview with Anne O'Garra, DISEASE MODELS & MECHANISMS, Vol: 6, Pages: 6-8, ISSN: 1754-8403
O'Garra A, Redford PS, McNab FW, et al., 2013, The Immune Response in Tuberculosis, ANNUAL REVIEW OF IMMUNOLOGY, VOL 31, Vol: 31, Pages: 475-527, ISSN: 0732-0582
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- Citations: 861
Nussenzweig M, O'Garra A, Smale S, et al., 2013, Symposium Participants Foreword, 78th Cold Spring Harbor Symposium on Quantitative Biology - Immunity and Tolerance, Publisher: COLD SPRING HARBOR LABORATORY PRESS, Pages: XV-XVI, ISSN: 0091-7451
O'Garra A, 2013, Systems Approach to Understand the Immune Response in Tuberculosis: An Iterative Process between Mouse Models and Human Disease, IMMUNITY AND TOLERANCE, Vol: 78, Pages: 173-177, ISSN: 0091-7451
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- Citations: 7
Bloom CI, Graham CM, Berry MP, et al., 2013, Correction: Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers., PLoS One, Vol: 8
[This corrects the article on p. e70630 in vol. 8.].
Pitt JM, Stavropoulos E, Redford PS, et al., 2012, Blockade of IL-10 Signaling during Bacillus Calmette-Guerin Vaccination Enhances and Sustains Th1, Th17, and Innate Lymphoid IFN-γ and IL-17 Responses and Increases Protection to <i>Mycobacterium tuberculosis</i> Infection, JOURNAL OF IMMUNOLOGY, Vol: 189, Pages: 4079-4087, ISSN: 0022-1767
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- Citations: 118
Bloom CI, Graham CM, Berry MPR, et al., 2012, Detectable Changes in The Blood Transcriptome Are Present after Two Weeks of Antituberculosis Therapy, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 149
Banchereau J, Pascual V, O'Garra A, 2012, From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines, NATURE IMMUNOLOGY, Vol: 13, Pages: 925-931, ISSN: 1529-2908
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- Citations: 293
Urry Z, Chambers ES, Xystrakis E, et al., 2012, The role of 1a,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL-10+CD4+T cells, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 42, Pages: 2697-2708, ISSN: 0014-2980
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- Citations: 148
Bloom C, Graham C, Berry M, et al., 2012, A change in blood transcriptional signatures accompanies successful tuberculosis therapy, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Howes A, Wu X, Zhao J, et al., 2012, The regulation of Interleukin-10 and Interleukin-12 production in macrophages: Investigating the differential production of IL-10 and IL-12 in C57BL/6 and BALB/c mice, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 303-304, ISSN: 0019-2805
O'Garra A, Pamer E, 2012, Host pathogens, CURRENT OPINION IN IMMUNOLOGY, Vol: 24, Pages: 361-363, ISSN: 0952-7915
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- Citations: 1
Durant L, Schnoeller C, Loebbermann J, et al., 2012, Roles for IL-10 in respiratory syncytial virus infection, 1st Biennial Symposium on Regulatory T Cells and T Helper Cells, Publisher: WILEY-BLACKWELL, Pages: 4-4, ISSN: 0019-2805
Everitt AR, Clare S, Pertel T, et al., 2012, IFITM3 restricts the morbidity and mortality associated with influenza., Nature, Vol: 484, Pages: 519-523
The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset of the population. Recent in vitro studies show that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the replication of multiple pathogenic viruses1, 2, 3, 4, 5, 6, 7. Both the magnitude and breadth of the IFITM proteins’ in vitro effects suggest that they are critical for intrinsic resistance to such viruses, including influenza viruses. Using a knockout mouse model8, we now test this hypothesis directly and find that IFITM3 is essential for defending the host against influenza A virus in vivo. Mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 ‘Spanish’ influenza9, 10. Similar increased viral replication is seen in vitro, with protection rescued by the re-introduction of Ifitm3. To test the role of IFITM3 in human influenza virus infection, we assessed the IFITM3 alleles of individuals hospitalized with seasonal or pandemic influenza H1N1/09 viruses. We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro. Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans.
Loebbermann J, Schnoeller C, Thornton H, et al., 2012, IL-10 Regulates Viral Lung Immunopathology during Acute Respiratory Syncytial Virus Infection in Mice, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 98
do Rosario APF, Lamb T, Spence P, et al., 2012, IL-27 Promotes IL-10 Production by Effector Th1 CD4<SUP>+</SUP> T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection, JOURNAL OF IMMUNOLOGY, Vol: 188, Pages: 1178-1190, ISSN: 0022-1767
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- Citations: 155
O'Garra A, Bloom CI, Graham CM, et al., 2012, The blood transcriptional signature of active tuberculosis is dominated by IFNγ and Type I IFNαβ signalling: potential biomarkers for diagnosis and treatment monitoring, European Congress of Immunology
Bloom CI, Graham CM, Berry MPR, et al., 2012, Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy, Tuberculosis EMBO
Li D, Romain G, Flamar A-L, et al., 2012, Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4<SUP>+</SUP> T cells, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 209, Pages: 109-121, ISSN: 0022-1007
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- Citations: 132
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