Publications
272 results found
do Rosario APF, Lamb T, Spence P, et al., 2012, IL-27 Promotes IL-10 Production by Effector Th1 CD4<SUP>+</SUP> T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection, JOURNAL OF IMMUNOLOGY, Vol: 188, Pages: 1178-1190, ISSN: 0022-1767
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- Citations: 155
O'Garra A, Bloom CI, Graham CM, et al., 2012, The blood transcriptional signature of active tuberculosis is dominated by IFNγ and Type I IFNαβ signalling: potential biomarkers for diagnosis and treatment monitoring, European Congress of Immunology
Bloom CI, Graham CM, Berry MPR, et al., 2012, Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy, Tuberculosis EMBO
Li D, Romain G, Flamar A-L, et al., 2012, Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4<SUP>+</SUP> T cells, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 209, Pages: 109-121, ISSN: 0022-1007
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- Citations: 132
Lowe DM, Redford PS, Wilkinson RJ, et al., 2012, Neutrophils in tuberculosis: friend or foe?, TRENDS IN IMMUNOLOGY, Vol: 33, Pages: 14-25, ISSN: 1471-4906
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- Citations: 223
Tattermusch S, Skinner JA, Chaussabel D, et al., 2012, Systems Biology Approaches Reveal a Specific Interferon-Inducible Signature in HTLV-1 Associated Myelopathy, PLOS PATHOGENS, Vol: 8, ISSN: 1553-7366
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- Citations: 71
Schnoeller C, Loebbermann J, Durant L, et al., 2011, Roles for IL-10 in RSV infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 199-199, ISSN: 0019-2805
O'Garra A, Inaba K, Liu Y-J, et al., 2011, Ralph M. Steinman (1943-2011) Obituary, IMMUNITY, Vol: 35, Pages: 651-652, ISSN: 1074-7613
Banchereau J, Cohn F, Inaba K, et al., 2011, Remembering Ralph Steinman, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 208, Pages: 2343-2346, ISSN: 0022-1007
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- Citations: 3
Medzhitov R, Shevach EM, Trinchieri G, et al., 2011, Highlights of 10 years of immunology in <i>Nature Reviews Immunology</i>, NATURE REVIEWS IMMUNOLOGY, Vol: 11, Pages: 693-702, ISSN: 1474-1733
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- Citations: 80
O'Garra A, 2011, Regulation of the immune response in tuberculosis: Lessons learned from mouse models and human disease, 9th Joint Meeting of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytokine-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: 58-58, ISSN: 1043-4666
Howes A, Wu X, Zhao J, et al., 2011, The Regulation of Interleukin 10 and Interleukin 12 in Macrophages, 9th Joint Meeting of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytokine-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: 56-56, ISSN: 1043-4666
Skinner JA, Baldwin N, Sharma M, et al., 2011, Whole Blood Transcriptional Monitoring of Acute HIV-1 Infection Reveals Differential Signatures of Host Immune Activation, Conference on AIDS Vaccine, Publisher: MARY ANN LIEBERT INC, Pages: A34-A34, ISSN: 0889-2229
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- Citations: 1
Wack A, Openshaw P, O'Garra A, 2011, Contribution of cytokines to pathology and protection in virus infection, CURRENT OPINION IN VIROLOGY, Vol: 1, Pages: 184-195, ISSN: 1879-6257
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- Citations: 21
McNab FW, Berry MPR, Graham CM, et al., 2011, Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 41, Pages: 1941-1947, ISSN: 0014-2980
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- Citations: 89
Gabrysova L, Christensen JR, Wu X, et al., 2011, Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3<SUP>+</SUP> regulatory T cells, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 41, Pages: 1242-1248, ISSN: 0014-2980
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- Citations: 78
Redford PS, Murray PJ, O'Garra A, 2011, The role of IL-10 in immune regulation during <i>M</i>. <i>tuberculosis</i> infection, MUCOSAL IMMUNOLOGY, Vol: 4, Pages: 261-270, ISSN: 1933-0219
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- Citations: 327
O'Garra A, Gabrysova L, Spits H, 2011, Quantitative events determine the differentiation and function of helper T cells, NATURE IMMUNOLOGY, Vol: 12, Pages: 288-294, ISSN: 1529-2908
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- Citations: 53
Yang HT, Wang Y, Zhao X, et al., 2011, NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation., Journal of Immunology, Vol: 4, Pages: 1989-1996
Although NF-κB1 p50/p105 has critical roles in immunity, the mechanism by which NF-κB1 regulates inflammatory responses is unclear. In this study, we analyzed the gene expression profile of LPS-stimulated Nfkb1(-/-) macrophages that lack both p50 and p105. Deficiency of p50/p105 selectively increased the expression of IFN-responsive genes, which correlated with increased IFN-β expression and STAT1 phosphorylation. IFN Ab-blocking experiments indicated that increased STAT1 phosphorylation and expression of IFN-responsive genes observed in the absence of p50/p105 depended upon autocrine IFN-β production. Markedly higher serum levels of IFN-β were observed in Nfkb1(-/-) mice than in wild-type mice following LPS injection, demonstrating that Nfkb1 inhibits IFN-β production under physiological conditions. TPL-2, a mitogen-activated protein kinase kinase kinase stabilized by association with the C-terminal ankyrin repeat domain of p105, negatively regulates LPS-induced IFN-β production by macrophages via activation of ERK MAPK. Retroviral expression of TPL-2 in Nfkb1(-/-) macrophages, which are deficient in endogenous TPL-2, reduced LPS-induced IFN-β secretion. Expression of the C-terminal ankyrin repeat domain of p105 in Nfkb1(-/-) macrophages, which rescued LPS activation of ERK, also inhibited IFN-β expression. These data indicate that p50/p105 negatively regulates LPS-induced IFN signaling in macrophages by stabilizing TPL-2, thereby facilitating activation of ERK.
McNab FW, Rajsbaum R, Stoye JP, et al., 2011, Tripartite-motif proteins and innate immune regulation, CURRENT OPINION IN IMMUNOLOGY, Vol: 23, Pages: 46-56, ISSN: 0952-7915
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- Citations: 194
Tattermusch S, Skinner J, Chaussabel D, et al., 2010, An interferon signature is associated with disease but not viral containment in chronic infection with the human T-cell lymphotropic virus type 1, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 188-188, ISSN: 0019-2805
Schnoeller C, Loebbermann J, Johansson C, et al., 2010, The role of IL-10 in RSV infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 176-176, ISSN: 0019-2805
Berry MPR, Graham CM, McNab FW, et al., 2010, An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis, NATURE, Vol: 466, Pages: 973-U98, ISSN: 0028-0836
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- Citations: 1331
Redford PS, Boonstra A, Read S, et al., 2010, Enhanced protection to <i>Mycobacterium tuberculosis</i> infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 40, Pages: 2200-2210, ISSN: 0014-2980
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- Citations: 183
Saraiva M, O'Garra A, 2010, The regulation of IL-10 production by immune cells, NATURE REVIEWS IMMUNOLOGY, Vol: 10, Pages: 170-181, ISSN: 1474-1733
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- Citations: 2070
Berry MPR, Graham CM, Bloch SJ, et al., 2009, SYSTEMS BIOLOGY APPROACHES CHARACTERISE THE HOST RESPONSE TO TUBERCULOSIS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A10-A10, ISSN: 0040-6376
O'Garra A, 2009, IL-10 producing Th I cells, Tri-Society Annual Conference of the International-Cytokine-Society/International-Society-of-Interferon-and-Cytokine-Research/Society-of-Leukocyte-Biology, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: 18-18, ISSN: 1043-4666
Kassiotis G, O'Garra A, 2009, Establishing the Follicular Helper Identity, IMMUNITY, Vol: 31, Pages: 450-452, ISSN: 1074-7613
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- Citations: 16
O'Garra A, Murphy KM, 2009, From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T<sub>H</sub>1 development, NATURE IMMUNOLOGY, Vol: 10, Pages: 929-932, ISSN: 1529-2908
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- Citations: 126
Kaiser F, Cook D, Papoutsopoulou S, et al., 2009, TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 206, Pages: 1863-1871, ISSN: 0022-1007
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- Citations: 132
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