Publications
272 results found
Hawrylowicz CM, O'Garra A, 2005, Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma, NATURE REVIEWS IMMUNOLOGY, Vol: 5, Pages: 271-283, ISSN: 1474-1733
- Author Web Link
- Cite
- Citations: 514
Barthlott T, Moncrieffe H, Veldhoen M, et al., 2005, CD25<SUP>+</SUP>CD4<SUP>+</SUP> T cells compete with naive CD4<SUP>+</SUP> T cells for IL-2 and exploit it for the induction of IL-10 production, INTERNATIONAL IMMUNOLOGY, Vol: 17, Pages: 279-288, ISSN: 0953-8178
- Author Web Link
- Cite
- Citations: 150
O'Garra A, Trinchieri G, 2004, Are dendritic cells afraid of commitment?, NATURE IMMUNOLOGY, Vol: 5, Pages: 1206-1208, ISSN: 1529-2908
- Author Web Link
- Cite
- Citations: 19
O'Garra A, Vieira PL, Vieira P, et al., 2004, IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage., J Clin Invest, Vol: 114, Pages: 1372-1378, ISSN: 0021-9738
Effective immune responses against pathogens are sometimes accompanied by strong inflammatory reactions. To minimize damage to self, the activation of the immune system also triggers anti-inflammatory circuits. Both inflammatory and anti-inflammatory reactions are normal components of the same immune response, which coordinately fight infections while preventing immune pathology. IL-10 is an important suppressive cytokine, produced by a large number of immune cells in addition to the antigen-driven IL-10-producing regulatory and the naturally occurring suppressor CD4+ T cells, which is a key player in anti-inflammatory immune responses. However, additional mechanisms have evolved to ensure that pathogen eradication is achieved with minimum damage to the host. Here we discuss those mechanisms that operate to regulate effector immune responses.
O'Garra A, Vieira PL, Vieira P, et al., 2004, IL-10-producing and naturally occurring CD4<SUP>+</SUP> Tregs:: limiting collateral damage, JOURNAL OF CLINICAL INVESTIGATION, Vol: 114, Pages: 1372-1378, ISSN: 0021-9738
- Author Web Link
- Cite
- Citations: 402
O'Garra A, Vieira P, 2004, Regulatory T cells and mechanisms of immune system control, NATURE MEDICINE, Vol: 10, Pages: 801-805, ISSN: 1078-8956
- Author Web Link
- Cite
- Citations: 635
Vieira PL, Christensen JR, Minaee S, et al., 2004, IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4<SUP>+</SUP>CD25<SUP>+</SUP> regulatory T cells, JOURNAL OF IMMUNOLOGY, Vol: 172, Pages: 5986-5993, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 515
Vicari AP, Vanbervliet B, Massacrier C, et al., 2004, In vivo manipulation of dendritic cell migration and activation to elicit antitumour immunity., Pages: 241-254, ISSN: 1528-2511
Two approaches have been pursued to elicit antitumour immunity: (i) induce recruitment of immature dendritic cells or their precursors at a site of antigen delivery, and (ii) induce activation of tumour-infiltrating dendritic cells (DCs). The recruitment of selected DC subtype conditions the class of the immune response. Each immature DC population displays a unique spectrum of chemokine responsiveness. For examples, Langerhans cells (LCs) migrate selectively in response to CCL20/MIP-3alpha (through CCR6), blood CD11c+ DC to MCP chemokines (through CCR2). All these chemokines are inducible in response to inflammatory stimuli. CCL20/MIP-3alpha in particular is only detected within inflamed epithelium, at the site of antigen entry, which is infiltrated by immature DCs. Furthermore, to reach the site of injury, sequential responsiveness might operate, blood DC precursors are recruited by a set of chemokines (MIP, MCP) while within the tissue other chemokines will direct their navigation (CCL20/MIP-3alpha). Of interest, when injected in vivo together with antigen, MCP-4/CCL13, but not CCL20/MIP-3alpha, recruits blood monocytes or blood DC precursors that promptly differentiate into typical DCs and that improve antitumour immune responses. After antigen uptake, DCs acquire, upon maturation, responsiveness to CCR7 ligands (CCL21/SLC/6Ckine, CCL19/ELC/MIP-3beta) due to receptor up-regulation. In particular, in the periphery, CCL21/SLC/6Ckine expressed by lymphatic vessels may direct into the lymph stream, antigen-loaded maturing DCs leaving the site of infection; while within lymph-node, CCL21/SLC/6Ckine plays a critical role in the entry of naïve T cells from the blood through HEV. In regard to its central role, we decided to investigate whether the expression of CCL21/SLC/6Ckine in tumour may lead to antitumour immune responses. C26 colon carcinoma tumour cell line transduced with CCL21/SLC/6Ckine showed reduced tumorigenicity when injected in vivo into immunocompet
O'Garra A, Robinson D, 2004, Development and function of T helper 1 cells, ADVANCES IN IMMUNOLOGY, VOL 83, Vol: 83, Pages: 133-162, ISSN: 0065-2776
- Author Web Link
- Cite
- Citations: 56
Seki Y, Inoue H, Nagata N, et al., 2003, SOCS-3 regulates onset and maintenance of T<sub>H</sub>2-mediated allergic responses, NATURE MEDICINE, Vol: 9, Pages: 1047-1054, ISSN: 1078-8956
- Author Web Link
- Cite
- Citations: 291
O'Garra A, Vieira P, 2003, Twenty-first century Foxp3, NATURE IMMUNOLOGY, Vol: 4, Pages: 304-306, ISSN: 1529-2908
- Author Web Link
- Cite
- Citations: 49
O'Garra A, Barrat FJ, 2003, In vitro generation of IL-10-producing regulatory CD4<SUP>+</SUP> T cells is induced by immunosuppressive drugs and inhibited by Th1-and Th2-inducing cytokines, IMMUNOLOGY LETTERS, Vol: 85, Pages: 135-139, ISSN: 0165-2478
- Author Web Link
- Cite
- Citations: 33
Boonstra A, Asselin-Paturel C, Gilliet M, et al., 2003, Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential toll-like receptor ligation, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 197, Pages: 101-109, ISSN: 0022-1007
- Author Web Link
- Cite
- Citations: 451
Vicari AP, Chiodoni C, Vaure C, et al., 2002, Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 196, Pages: 541-549, ISSN: 0022-1007
- Author Web Link
- Cite
- Citations: 289
Robinson DS, O'Garra A, 2002, Further checkpoints in Th1 development, IMMUNITY, Vol: 16, Pages: 755-758, ISSN: 1074-7613
- Author Web Link
- Cite
- Citations: 165
Kurata H, Lee HJ, McClanahan T, et al., 2002, Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development, JOURNAL OF IMMUNOLOGY, Vol: 168, Pages: 4538-4545, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 46
Gilliet M, Boonstra A, Paturel C, et al., 2002, The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 195, Pages: 953-958, ISSN: 0022-1007
- Author Web Link
- Cite
- Citations: 421
Barrat FJ, Cua DJ, Boonstra A, et al., 2002, In vitro generation of interleukin 10-producing regulatory CD4<SUP>+</SUP> T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 195, Pages: 603-616, ISSN: 0022-1007
- Author Web Link
- Cite
- Citations: 888
Julia V, Hessel EM, Malherbe L, et al., 2002, A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure, IMMUNITY, Vol: 16, Pages: 271-283, ISSN: 1074-7613
- Author Web Link
- Cite
- Citations: 161
Heath VL, Kurata H, Lee HJ, et al., 2002, Checkpoints in the regulation of T helper 1 responses, Publisher: SPRINGER-VERLAG BERLIN
- Author Web Link
- Cite
- Citations: 8
Asselin-Paturel C, Boonstra A, Dalod M, et al., 2001, Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology, NATURE IMMUNOLOGY, Vol: 2, Pages: 1144-1150, ISSN: 1529-2908
- Author Web Link
- Cite
- Citations: 814
Boonstra A, Barrat FJ, Crain C, et al., 2001, 1α,25-dihydroxyvitamin D3 has a direct effect on naive CD4<SUP>+</SUP> T cells to enhance the development of Th2 cells, JOURNAL OF IMMUNOLOGY, Vol: 167, Pages: 4974-4980, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 857
Neighbors M, Xu XL, Barrat FJ, et al., 2001, A critical role for interleukin 18 in primary and memory effector responses to <i>Listeria monocytogenes</i> that extends beyond its effects on interferon γ production, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 194, Pages: 343-354, ISSN: 0022-1007
- Author Web Link
- Cite
- Citations: 111
Chensue SW, Lukacs NW, Yang TY, et al., 2001, Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 193, Pages: 573-584, ISSN: 0022-1007
- Author Web Link
- Cite
- Citations: 161
Brieland JK, Jackson C, Menzel F, et al., 2001, Cytokine networking in lungs of immunocompetent mice in response to inhaled <i>Aspergillus fumigatus</i>, INFECTION AND IMMUNITY, Vol: 69, Pages: 1554-1560, ISSN: 0019-9567
- Author Web Link
- Cite
- Citations: 91
Moore KW, Malefyt RD, Coffman RL, et al., 2001, Interleukin-10 and the interleukin-10 receptor, Publisher: ANNUAL REVIEWS
- Author Web Link
- Cite
- Citations: 5124
Takemoto N, Kamogawa Y, Lee HJ, et al., 2000, Cutting edge: Chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster, JOURNAL OF IMMUNOLOGY, Vol: 165, Pages: 6687-6691, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 125
Brieland JK, Jackson C, Hurst S, et al., 2000, Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative <i>Legionella pneumophila</i> lung infection, INFECTION AND IMMUNITY, Vol: 68, Pages: 6567-6573, ISSN: 0019-9567
- Author Web Link
- Cite
- Citations: 44
O'Garra A, Arai N, 2000, The molecular basis of T helper 1 and T helper 2 cell differentiation, TRENDS IN CELL BIOLOGY, Vol: 10, Pages: 542-550, ISSN: 0962-8924
- Author Web Link
- Cite
- Citations: 322
Castro AG, Neighbors M, Hurst SD, et al., 2000, Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 192, Pages: 1529-1534, ISSN: 0022-1007
- Author Web Link
- Cite
- Citations: 48
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.