Publications
272 results found
Hussell T, Spender LC, Georgiou A, et al., 1996, Th1 and Th2 cytokine induction in pulmonary T cells during infection with respiratory syncytial virus, JOURNAL OF GENERAL VIROLOGY, Vol: 77, Pages: 2447-2455, ISSN: 0022-1317
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- Citations: 136
Vicari AP, Mocci S, Openshaw P, et al., 1996, Mouse gamma delta TCR(+)NK1.1(+) thymocytes specifically produce interleukin-4, are major histocompatibility complex class I independent, and are developmentally related to alpha beta TCR(+)NK1.1(+) thymocytes, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 26, Pages: 1424-1429, ISSN: 0014-2980
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- Citations: 64
Hosken N, Hartley S, Heath A, et al., 1996, The effect of antigen dose on CD4+ T cell phenotype development in a TCR transgenic model, FASEB JOURNAL, Vol: 10, Pages: 285-285, ISSN: 0892-6638
Hartley SB, OGarra A, 1996, A T cell receptor-transgenic mouse model to study the role of T helper cells in peripheral T cell tolerance., FASEB JOURNAL, Vol: 10, Pages: 1028-1028, ISSN: 0892-6638
Murphy E, Shibuya K, Hosken N, et al., 1996, Reversibility of T helper 1 and 2 populations is lost after long-term stimulation, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 183, Pages: 901-913, ISSN: 0022-1007
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- Citations: 380
Wenner CA, Guler ML, Macatonia SE, et al., 1996, Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development, JOURNAL OF IMMUNOLOGY, Vol: 156, Pages: 1442-1447, ISSN: 0022-1767
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- Citations: 280
Brocke S, Gijbels K, Allegretta M, et al., 1996, Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein, NATURE, Vol: 379, Pages: 343-346, ISSN: 0028-0836
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- Citations: 363
OGarra A, Murphy K, 1996, Role of cytokines in development of Th1 and Th2 cells, TH1 AND TH2 CELLS IN HEALTH AND DISEASE, Vol: 63, Pages: 1-13, ISSN: 1015-0145
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- Citations: 59
OPENSHAW P, MURPHY EE, HOSKEN NA, et al., 1995, HETEROGENEITY OF INTRACELLULAR CYTOKINE SYNTHESIS AT THE SINGLE-CELL LEVEL IN POLARIZED T-HELPER-1 AND T-HELPER-2 POPULATIONS, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 182, Pages: 1357-1367, ISSN: 0022-1007
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- Citations: 504
HOSKEN NA, SHIBUYA K, HEATH AW, et al., 1995, THE EFFECT OF ANTIGEN DOSE ON CD4(+) T-HELPER CELL PHENOTYPE DEVELOPMENT IN A T-CELL RECEPTOR-ALPHA-BETA-TRANSGENIC MODEL, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 182, Pages: 1579-1584, ISSN: 0022-1007
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- Citations: 660
Olsson T, 1995, Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis., Neurology, Vol: 45, Pages: S11-S15, ISSN: 0028-3878
In both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis, the regulation of the cytokine spectrum and production is likely to have a decisive influence on disease outcome. Studies of cytokines, however, are hampered by the autocrine or paracrine nature of cytokines. Studies of cellular production by messenger RNA detection or cellular secretion are therefore necessary. Collective data suggest that certain cytokines associated with the TH1 phenotype or lymphocytes, such as tumor necrosis factor alpha, lymphotoxin, interleukin-12, and interferon gamma, may promote disease, while cytokines produced by the TH2 subset, such as interleukin-10, may limit disease. In addition, transforming growth factor beta is a putative disease downregulator. Increased knowledge in this field will likely lead to improved therapy for MS patients.
MACATONIA SE, HOSKEN NA, LITTON M, et al., 1995, DENDRITIC CELLS PRODUCE IL-12 AND DIRECT THE DEVELOPMENT OF TH1 CELLS FROM NAIVE CD4(+) T-CELLS, JOURNAL OF IMMUNOLOGY, Vol: 154, Pages: 5071-5079, ISSN: 0022-1767
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- Citations: 1305
HSIEH CS, MACATONIA SE, OGARRA A, et al., 1995, T-CELL GENETIC BACKGROUND DETERMINES DEFAULT T-HELPER PHENOTYPE DEVELOPMENT IN-VITRO, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 181, Pages: 713-721, ISSN: 0022-1007
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- Citations: 412
OGarra A, Hosken N, Macatonia S, et al., 1995, The role of macrophage- and dendritic cell-derived IL12 in Th1 phenotype development, RESEARCH IN IMMUNOLOGY, Vol: 146, Pages: 466-470, ISSN: 0923-2494
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- Citations: 45
LITTON MJ, SANDER B, MURPHY E, et al., 1994, EARLY EXPRESSION OF CYTOKINES IN LYMPH-NODES AFTER TREATMENT IN-VIVO WITH STAPHYLOCOCCUS ENTEROTOXIN-B, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 175, Pages: 47-58, ISSN: 0022-1759
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- Citations: 62
MURPHY EE, TERRES G, MACATONIA SE, et al., 1994, B7 AND INTERLEUKIN-12 COOPERATE FOR PROLIFERATION AND INTERFERON-GAMMA PRODUCTION BY MOUSE T-HELPER CLONES THAT ARE UNRESPONSIVE TO B7 COSTIMULATION, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 180, Pages: 223-231, ISSN: 0022-1007
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- Citations: 363
OGARRA A, MURPHY K, 1994, ROLE OF CYTOKINES IN DETERMINING T-LYMPHOCYTE FUNCTION, CURRENT OPINION IN IMMUNOLOGY, Vol: 6, Pages: 458-466, ISSN: 0952-7915
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- Citations: 387
OGARRA A, MURPHY K, 1993, T-CELL SUBSETS IN AUTOIMMUNITY, CURRENT OPINION IN IMMUNOLOGY, Vol: 5, Pages: 880-886, ISSN: 0952-7915
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- Citations: 120
MINOPRIO P, ELCHEIKH MC, MURPHY E, et al., 1993, XID-ASSOCIATED RESISTANCE TO EXPERIMENTAL CHAGAS-DISEASE IS IFN-GAMMA DEPENDENT, JOURNAL OF IMMUNOLOGY, Vol: 151, Pages: 4200-4208, ISSN: 0022-1767
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- Citations: 88
OGARRA A, MACATONIA SE, HSIEH CS, et al., 1993, REGULATORY ROLE OF IL4 AND OTHER CYTOKINES IN T-HELPER CELL-DEVELOPMENT IN AN ALPHA-BETA-TCR TRANSGENIC MOUSE SYSTEM, Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, Pages: 620-625, ISSN: 0923-2494
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- Citations: 18
OGARRA A, 1993, THE IMMUNOBIOLOGY OF INTERLEUKIN-4 - INTRODUCTION, Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, Pages: 567-568, ISSN: 0923-2494
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- Citations: 5
MACATONIA SE, HSIEH CS, MURPHY KM, et al., 1993, DENDRITIC CELLS AND MACROPHAGES ARE REQUIRED FOR TH1 DEVELOPMENT OF CD4+ T-CELLS FROM ALPHA-BETA-TCR TRANSGENIC MICE - IL-12 SUBSTITUTION FOR MACROPHAGES TO STIMULATE IFN-GAMMA PRODUCTION IS IFN-GAMMA-DEPENDENT, INTERNATIONAL IMMUNOLOGY, Vol: 5, Pages: 1119-1128, ISSN: 0953-8178
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- Citations: 343
MURPHY E, HIENY S, SHER A, et al., 1993, DETECTION OF IN-VIVO EXPRESSION OF INTERLEUKIN-10 USING A SEMIQUANTITATIVE POLYMERASE CHAIN-REACTION METHOD IN SCHISTOSOMA-MANSONI-INFECTED MICE, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 162, Pages: 211-223, ISSN: 0022-1759
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- Citations: 105
HSIEH CS, MACATONIA SE, TRIPP CS, et al., 1993, DEVELOPMENT OF TH1 CD4+ T-CELLS THROUGH IL-12 PRODUCED BY LISTERIA-INDUCED MACROPHAGES, SCIENCE, Vol: 260, Pages: 547-549, ISSN: 0036-8075
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- Citations: 2928
Hsieh CS, Macatonia SE, O'Garra A, et al., 1993, Pathogen-induced Th1 phenotype development in CD4+ alpha beta-TCR transgenic T cells is macrophage dependent., Int Immunol, Vol: 5, Pages: 371-382, ISSN: 0953-8178
We used an ovalbumin (OVA)-specific alpha beta-TCR transgenic mouse system to examine the cellular basis of CD4+ T helper (Th) phenotype development in vitro. Heat-killed Listeria monocytogenes (HKLM) strongly promotes the in vitro development of a Th1 phenotype in OVA-specific transgenic T cells. Listeria monocytogenes effects to promote the Th1 phenotype are antigen presenting cell (APC) dependent and occur when splenic APCs, but not the B cell hybridoma TA3, are present during T cell activation. However, addition of FACS-sorted macrophages to TA3 activated cultures restores the ability of Listeria to induce Th1 development. This effect on T cell development does not require MHC-restricted antigen presentation by macrophages, but may act through soluble factors. Although the presence of interferon gamma is necessary for Listeria induction of Th1 development, IFN-gamma alone is insufficient to induce Th1 development. Furthermore, Listeria induction of the Th1 phenotype does not require several known products of activated macrophages, including interleukin-1 (IL-1), tumor necrosis factor (TNF-alpha), IL-6, or nitric oxide. Although transforming growth factor-beta (TGF-beta) may mediate some Listeria effects, it does not fully reconstitute Listeria effects to promote Th1 development. In summary, host interactions with bacterial pathogens can affect the development of specific Th subsets, allowing innate immune cells to direct development of specific immune phenotype. For Listeria monocytogenes, the induction of the Th1 phenotype may involve a novel cytokine distinct from several known factors produced by activated macrophages.
Macatonia SE, Doherty TM, Knight SC, et al., 1993, Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production, J.Immunol., Vol: 150, Pages: 3755-3765
MOORE KW, OGARRA A, MALEFYT RD, et al., 1993, INTERLEUKIN-10, ANNUAL REVIEW OF IMMUNOLOGY, Vol: 11, Pages: 165-190, ISSN: 0732-0582
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- Citations: 2379
Moore KW, O'Garra A, de Waal Malefyt R, et al., 1993, Interleukin-10.
In the three years since its discovery, the pleiotropic cytokine interleukin-10 (IL-10) has been implicated as an important regulator of the functions of lymphoid and myeloid cells. IL-10's ability to block activation of cytokine synthesis and several accessory cell functions of macrophage renders this cytokine a potent suppressor of the effector functions of macrophages, T cells, and NK cells. In addition, IL-10 likely contributes to regulating proliferation and differentiation of B cells, mast cells, and thymocytes. The Epstein-Barr virus genome encodes a homolog of IL-10 (BCFR1, viral IL-10, vIL-10) which shares many of the cellular cytokine's biological activities and may therefore play a role in the host-virus interaction. This article reviews current studies of IL-10's biological activities and discusses its possible roles in regulation of immune responses.
HSIEH CS, HEIMBERGER AB, GOLD JS, et al., 1992, DIFFERENTIAL REGULATION OF T-HELPER PHENOTYPE DEVELOPMENT BY INTERLEUKIN-4 AND INTERLEUKIN-10 IN AN ALPHA-BETA-T-CELL-RECEPTOR TRANSGENIC SYSTEM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 89, Pages: 6065-6069, ISSN: 0027-8424
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- Citations: 771
HOWARD M, OGARRA A, ISHIDA H, et al., 1992, BIOLOGICAL PROPERTIES OF INTERLEUKIN-10, JOURNAL OF CLINICAL IMMUNOLOGY, Vol: 12, Pages: 239-247, ISSN: 0271-9142
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- Citations: 318
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