Publications
271 results found
O'Garra A, Howard M, 1992, IL-10 production by CD5 B cells., Ann N Y Acad Sci, Vol: 651, Pages: 182-199, ISSN: 0077-8923
OGARRA A, VIEIRA P, 1992, POLYMERASE CHAIN-REACTION FOR DETECTION OF CYTOKINE GENE-EXPRESSION, CURRENT OPINION IN IMMUNOLOGY, Vol: 4, Pages: 211-215, ISSN: 0952-7915
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- Citations: 55
OGARRA A, CHANG R, GO N, et al., 1992, LY-1 B (B-1) CELLS ARE THE MAIN SOURCE OF B-CELL-DERIVED INTERLEUKIN-10, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 22, Pages: 711-717, ISSN: 0014-2980
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- Citations: 498
RUGO HS, OHANLEY P, BISHOP AG, et al., 1992, LOCAL CYTOKINE PRODUCTION IN A MURINE MODEL OF ESCHERICHIA-COLI PYELONEPHRITIS, Publisher: ROCKEFELLER UNIV PRESS, Pages: 1032-1039, ISSN: 0021-9738
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- Citations: 85
O'Garra A, Howard M, 1992, Cytokines and Ly-1 (B1) B cells., Int Rev Immunol, Vol: 8, Pages: 219-234, ISSN: 0883-0185
In an attempt to elucidate the possible role of cytokines in autocrine growth of Ly-1+B cells, and the role of this subset of B cells in immune regulation, both in normal and diseased hosts, we have performed a systematic analysis of cytokine production by a series of mouse Ly-1+B lymphomas, as well as normal peritoneal Ly-1+ and conventional B cells. The lymphomas all express TGF-beta, and some express IL-3 and IL-4. We observed that both the lymphomas and the peritoneal cells produce TNF-alpha, TNF-beta and IL-6. Another cytokine, IL-10, is produced predominantly by peritoneal Ly-1+B cells from healthy mice and by Ly-1+ B lymphomas, but not by conventional B cells. As IL-10 regulates the production of monokines and a subset of T-cell derived cytokines, our results suggest a broad immunoregulatory role for Ly-1 B cells. To complement these studies we have also examined the responses of Ly-1 B cells to mitogens and cytokines previously shown to stimulate conventional B cells. In summary, Ly-1 B cells, in contrast to conventional B cells do not respond to anti-Ig antibodies, even in the presence of IL-4. They do respond to LPS, and this response is preferentially enhanced by IL-5, and marginally enhanced by IL-3. Surprisingly LPS-induced proliferation of peritoneal B cells is inhibited by IL-6 and to a greater extent by IL-10. Whether this inhibition is a result of differentiation into Ig secreting cells is currently being evaluated. We discuss our findings in terms of the potential of Ly-1 B cells to regulate their own development and the immunocompetence of other cells.
FIORENTINO DF, ZLOTNIK A, MOSMANN TR, et al., 1991, IL-10 INHIBITS CYTOKINE PRODUCTION BY ACTIVATED MACROPHAGES, JOURNAL OF IMMUNOLOGY, Vol: 147, Pages: 3815-3822, ISSN: 0022-1767
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- Citations: 2610
Fiorentino DF, Zlotnik A, Mosmann TR, et al., 1991, Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815-3822., J Immunol, Vol: 197, Pages: 1539-1546
MOSMANN TR, SCHUMACHER JH, STREET NF, et al., 1991, DIVERSITY OF CYTOKINE SYNTHESIS AND FUNCTION OF MOUSE CD4+ T-CELLS, IMMUNOLOGICAL REVIEWS, Vol: 123, Pages: 209-229, ISSN: 0105-2896
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- Citations: 386
FIORENTINO DF, ZLOTNIK A, VIEIRA P, et al., 1991, IL-10 ACTS ON THE ANTIGEN-PRESENTING CELL TO INHIBIT CYTOKINE PRODUCTION BY TH1 CELLS, JOURNAL OF IMMUNOLOGY, Vol: 146, Pages: 3444-3451, ISSN: 0022-1767
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- Citations: 1831
Fiorentino DF, Zlotnik A, Vieira P, et al., 1991, Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444-3451., J Immunol, Vol: 197, Pages: 1531-1538
OGARRA A, STAPLETON G, DHAR V, et al., 1990, PRODUCTION OF CYTOKINES BY MOUSE B-CELLS - B-LYMPHOMAS AND NORMAL B-CELLS PRODUCE INTERLEUKIN-10, INTERNATIONAL IMMUNOLOGY, Vol: 2, Pages: 821-832, ISSN: 0953-8178
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- Citations: 374
SUDA T, OGARRA A, MACNEIL I, et al., 1990, IDENTIFICATION OF A NOVEL THYMOCYTE GROWTH-PROMOTING FACTOR DERIVED FROM B-CELL LYMPHOMAS, CELLULAR IMMUNOLOGY, Vol: 129, Pages: 228-240, ISSN: 0008-8749
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- Citations: 94
OGARRA A, BARBIS D, WU J, et al., 1989, THE BCL1B LYMPHOMA RESPONDS TO IL-4, IL-5, AND GM-CSF, CELLULAR IMMUNOLOGY, Vol: 123, Pages: 189-200, ISSN: 0008-8749
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- Citations: 39
O'Garra A, 1989, Interleukins and the immune system 2., Lancet, Vol: 1, Pages: 1003-1005, ISSN: 0140-6736
OGARRA A, 1989, INTERLEUKINS AND THE IMMUNE-SYSTEM .2., LANCET, Vol: 1, Pages: 1003-1005, ISSN: 0140-6736
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- Citations: 92
OGARRA A, 1989, INTERLEUKINS AND THE IMMUNE SYSTEM-1, LANCET, Vol: 1, Pages: 943-947, ISSN: 0140-6736
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- Citations: 148
O'Garra A, Barbis D, Harada N, et al., 1989, Constitutive production of lymphokines by cloned murine B-cell lymphomas--CH12 B lymphoma produces interleukin-4., J Mol Cell Immunol, Vol: 4, Pages: 149-158, ISSN: 0724-6803
B cells can be activated by T-independent antigens or mitogens such as lipopolysaccharide (LPS) which will induce proliferation and differentiation of the B cells into Ig-secreting cells, without the intervention of T cells. The precise mechanism of T-independent proliferation and differentiation of B cells is still unclear. It is possible however that antigen-stimulated B cells may produce some factors which play a role in T-independent B-cell responses. In addition, since it has now been established that B cells can function as antigen-presenting cells, it is possible that they too secrete a molecule which is involved in the activation of T cells, analogous to IL-1 production by antigen-presenting macrophages. A number of human B-cell lines, as well as human normal B cells activated appropriately, have been shown to produce various cytokines, and similar studies are now being undertaken in the mouse. In the present study, six cloned murine B-cell lymphomas of different origin were analyzed for the presence of mRNA encoding a number of lymphokines by hybridization of specific cDNA probes to poly-A RNA, followed by the sensitive S1 nuclease digestion technique. The lymphokines included (IL-) 1, 2, 3, 4, 5, and neuroleukin. Whereas none of the lines expressed detectable levels of IL-2, IL-3, or IL-5 mRNA, all the lines expressed high levels of neuroleukin mRNA. Three of the lymphomas (CH12, CH31, and NBL) expressed low levels of IL-1 mRNA. The most striking finding was that one lymphoma, CH12, constitutively expressed IL-4 mRNA. This mRNA appeared to be functional, as IL-4 activity measured by the HT-2 T cell proliferation assay could be detected in supernatants collected from CH12 cells. The growth-inducing activity of CH12 supernatant on HT-2 cells could be completely blocked by an anti-IL-4 monoclonal (11B11), but not by an anti-IL-2 antibody (S4B6), consistent with our observations that CH12 cells produce IL-4 but not IL-2. CH12 cells were also found to express h
SCHUMACHER JH, OGARRA A, SHRADER B, et al., 1988, THE CHARACTERIZATION OF 4 MONOCLONAL-ANTIBODIES SPECIFIC FOR MOUSE IL-5 AND DEVELOPMENT OF MOUSE AND HUMAN IL-5 ENZYME-LINKED IMMUNOSORBENT, JOURNAL OF IMMUNOLOGY, Vol: 141, Pages: 1576-1581, ISSN: 0022-1767
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- Citations: 345
HODGKIN PD, BOND MW, OGARRA A, et al., 1988, IDENTIFICATION OF IL-6 AS A T-CELL-DERIVED FACTOR THAT ENHANCES THE PROLIFERATIVE RESPONSE OF THYMOCYTES TO IL-4 AND PHORBOL-MYRISTATE ACETATE, JOURNAL OF IMMUNOLOGY, Vol: 141, Pages: 151-157, ISSN: 0022-1767
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- Citations: 84
OGARRA A, UMLAND S, DEFRANCE T, et al., 1988, B-CELL FACTORS ARE PLEIOTROPIC, IMMUNOLOGY TODAY, Vol: 9, Pages: 45-+, ISSN: 0167-5699
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- Citations: 277
O'Garra A, Umland S, De France T, et al., 1988, 'B-cell factors' are pleiotropic, Immunology Today, Vol: 9, Pages: 45-54, ISSN: 0167-5699
For many years, it was believed that the soluble factors produced by T cells which regulate B-cell proliferation and differentiation were specific to B lymphocytes. But this theory has been largely overturned lately: far from being B-cell specific, B-cell factors influence a wide variety of cell types. In addition, soluble factors from non-T cells also appear to be able to regulate B cells. In this article and the accompanying centre-page diagram, Anne O'Garra and colleagues review the properties of B-cell factors and their increasingly complex network of influence. © 1988.
SCOTT DW, OGARRA A, WARREN D, et al., 1987, LYMPHOMA MODELS FOR B-CELL ACTIVATION AND TOLERANCE .6. REVERSAL OF ANTI-IG-MEDIATED NEGATIVE SIGNALING BY T-CELL-DERIVED LYMPHOKINES, JOURNAL OF IMMUNOLOGY, Vol: 139, Pages: 3924-3929, ISSN: 0022-1767
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- Citations: 45
KLAUS GGB, BIJSTERBOSCH MK, OGARRA A, et al., 1987, RECEPTOR SIGNALING AND CROSSTALK IN LYMPHOCYTES-B, IMMUNOLOGICAL REVIEWS, Vol: 99, Pages: 19-38, ISSN: 0105-2896
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- Citations: 126
SCOTT DW, CHACE JH, WARNER GL, et al., 1987, ROLE OF T-CELL-DERIVED LYMPHOKINES IN 2 MODELS OF B-CELL TOLERANCE, IMMUNOLOGICAL REVIEWS, Vol: 99, Pages: 153-171, ISSN: 0105-2896
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- Citations: 50
OGARRA A, RIGLEY KP, HOLMAN M, et al., 1987, B-CELL-STIMULATORY FACTOR-I REVERSES FC-RECEPTOR-MEDIATED INHIBITION OF LYMPHOCYTE-B ACTIVATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 84, Pages: 6254-6258, ISSN: 0027-8424
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- Citations: 73
OGARRA A, WARREN DJ, HOLMAN M, et al., 1986, EFFECTS OF CYCLOSPORINE ON RESPONSES OF MURINE B-CELLS TO T-CELL-DERIVED LYMPHOKINES, JOURNAL OF IMMUNOLOGY, Vol: 137, Pages: 2220-2224, ISSN: 0022-1767
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- Citations: 31
OGARRA A, WARREN DJ, HOLMAN M, et al., 1986, INTERLEUKIN-4 (B-CELL GROWTH FACTOR-II EOSINOPHIL DIFFERENTIATION FACTOR) IS A MITOGEN AND DIFFERENTIATION FACTOR FOR PREACTIVATED MURINE LYMPHOCYTES-B, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 83, Pages: 5228-5232, ISSN: 0027-8424
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- Citations: 81
SANDERSON CJ, OGARRA A, WARREN DJ, et al., 1986, EOSINOPHIL DIFFERENTIATION FACTOR ALSO HAS B-CELL GROWTH-FACTOR ACTIVITY - PROPOSED NAME INTERLEUKIN-4, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 83, Pages: 437-440, ISSN: 0027-8424
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- Citations: 230
KLAUS GGB, OGARRA A, BIJSTERBOSCH MK, et al., 1986, ACTIVATION AND PROLIFERATION SIGNALS IN MOUSE B-CELLS .8. INDUCTION OF DNA-SYNTHESIS IN B-CELLS BY A COMBINATION OF CALCIUM IONOPHORES AND PHORBOL-MYRISTATE ACETATE, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 16, Pages: 92-97, ISSN: 0014-2980
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- Citations: 154
OGARRA A, WARREN DJ, SANDERSON CJ, et al., 1986, INTERLEUKIN-4 (B-CELL GROWTH FACTOR-II EOSINOPHIL DIFFERENTIATION FACTOR) IS A MITOGEN AND DIFFERENTIATION FACTOR FOR PREACTIVATED MURINE LYMPHOCYTES-B, CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, Vol: 132, Pages: 133-141, ISSN: 0070-217X
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- Citations: 6
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