Imperial College London
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ProfessorAnneO'Garra

Faculty of Medicine, National Heart & Lung Institute

Chair in Infection Immunology
 
 
 
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a.ogarra

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moreira-Teixeira:2018:10.1084/jem.20180325,
author = {Moreira-Teixeira, L and Mayer-Barber, K and Sher, A and O'Garra, A},
doi = {10.1084/jem.20180325},
journal = {Journal of Experimental Medicine},
pages = {1273--1285},
title = {Type I interferons in tuberculosis: Foe and occasionally friend},
url = {http://dx.doi.org/10.1084/jem.20180325},
volume = {215},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection. Type I interferons (IFN) regulate a broad family of genes that either stimulate or inhibit immune function, having both host-protective and detrimental effects, and exhibit well-characterized antiviral activity. Transcriptional studies have uncovered a potential deleterious role for type I IFN in active tuberculosis. Since then, additional studies in human tuberculosis and experimental mouse models of M. tuberculosis infection support the concept that type I IFN promotes both bacterial expansion and disease pathogenesis. More recently, studies in a different setting have suggested a putative protective role for type I IFN. In this study, we discuss the mechanistic and contextual factors that determine the detrimental versus beneficial outcomes of type I IFN induction during M. tuberculosis infection, from human disease to experimental mouse models of tuberculosis.
AU  - Moreira-Teixeira,L
AU  - Mayer-Barber,K
AU  - Sher,A
AU  - O'Garra,A
DO  - 10.1084/jem.20180325
EP  - 1285
PY  - 2018///
SN  - 0022-1007
SP  - 1273
TI  - Type I interferons in tuberculosis: Foe and occasionally friend
T2  - Journal of Experimental Medicine
UR  - http://dx.doi.org/10.1084/jem.20180325
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29666166
UR  - http://hdl.handle.net/10044/1/59286
VL  - 215
ER  -
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