Imperial College London

DrAlessandraPinna

Faculty of EngineeringDepartment of Materials

Imperial College Research Fellow
 
 
 
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Contact

 

a.pinna

 
 
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Location

 

2M14Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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28 results found

Naruphontjirakul P, Li S, Pinna A, Barrak F, Chen S, Redpath AN, Rankin SM, Porter AE, Jones JRet al., 2022, Interaction of monodispersed strontium containing bioactive glass nanoparticles with macrophages, BIOMATERIALS ADVANCES, Vol: 133

Journal article

Kumar P, Kalaiarasan G, Porter AE, Pinna A, Kłosowski MM, Demokritou P, Chung KF, Pain C, Arvind DK, Arcucci R, Adcock IM, Dilliway Cet al., 2021, An overview of methods of fine and ultrafine particle collection for physicochemical characterisation and toxicity assessments., Science of the Total Environment, Vol: 756, Pages: 1-22, ISSN: 0048-9697

Particulate matter (PM) is a crucial health risk factor for respiratory and cardiovascular diseases. The smaller size fractions, ≤2.5 μm (PM2.5; fine particles) and ≤0.1 μm (PM0.1; ultrafine particles), show the highest bioactivity but acquiring sufficient mass for in vitro and in vivo toxicological studies is challenging. We review the suitability of available instrumentation to collect the PM mass required for these assessments. Five different microenvironments representing the diverse exposure conditions in urban environments are considered in order to establish the typical PM concentrations present. The highest concentrations of PM2.5 and PM0.1 were found near traffic (i.e. roadsides and traffic intersections), followed by indoor environments, parks and behind roadside vegetation. We identify key factors to consider when selecting sampling instrumentation. These include PM concentration on-site (low concentrations increase sampling time), nature of sampling sites (e.g. indoors; noise and space will be an issue), equipment handling and power supply. Physicochemical characterisation requires micro- to milli-gram quantities of PM and it may increase according to the processing methods (e.g. digestion or sonication). Toxicological assessments of PM involve numerous mechanisms (e.g. inflammatory processes and oxidative stress) requiring significant amounts of PM to obtain accurate results. Optimising air sampling techniques are therefore important for the appropriate collection medium/filter which have innate physical properties and the potential to interact with samples. An evaluation of methods and instrumentation used for airborne virus collection concludes that samplers operating cyclone sampling techniques (using centrifugal forces) are effective in collecting airborne viruses. We highlight that predictive modelling can help to identify pollution hotspots in an urban environment for the efficient collection of PM mass. This review provides

Journal article

Pinna A, Baghbaderani MT, Hernandez VV, Naruphontjirakul P, Li S, McFarlane T, Hachim D, Stevens MM, Porter AE, Jones JRet al., 2021, Nanoceria provides antioxidant and osteogenic properties to mesoporous silica nanoparticles for osteoporosis treatment, ACTA BIOMATERIALIA, Vol: 122, Pages: 365-376, ISSN: 1742-7061

Journal article

Avitabile E, Senes N, D'Avino C, Tsamesidis I, Pinna A, Medici S, Pantaleo Aet al., 2020, The potential antimalarial efficacy of hemocompatible silver nanoparticles fromArtemisiaspecies againstP.falciparumparasite, PLoS One, Vol: 15, Pages: 1-17, ISSN: 1932-6203

Malaria represents one of the most common infectious diseases which becoming an impellent public health problem worldwide. Antimalarial classical medications include quinine-based drugs, like chloroquine, and artesunate, a derivative of artemisinin, a molecule found in the plant Artemisia annua. Such therapeutics are very effective but show heavy side effects like drug resistance. In this study, “green” silver nanoparticles (AgNPs) have been prepared from two Artemisia species (A. abrotanum and A. arborescens), traditionally used in folk medicine as a remedy for different conditions, and their potential antimalarial efficacy have been assessed. AgNPs have been characterized by UV-Vis, dynamic light scattering and zeta potential, FTIR, XRD, TEM and EDX. The structural characterization has demonstrated the spheroidal shape of nanoparticles and dimensions under 50 nm, useful for biomedical studies. Zeta potential analysis have shown the stability and dispersion of green AgNPs in aqueous medium without aggregation. AgNPs hemocompatibility and antimalarial activity have been studied in Plasmodium falciparum cultures in in vitro experiments. The antiplasmodial effect has been assessed using increasing doses of AgNPs (0.6 to 7.5 μg/mL) on parasitized red blood cells (pRBCs). Obtained data showed that the hemocompatibility of AgNPs is related to their synthetic route and depends on the administered dose. A. abrotanum-AgNPs (1) have shown the lowest percentage of hemolytic activity on pRBCs, underlining their hemocompatibility. These results are in accordance with the lower levels of parasitemia observed after A. abrotanum-AgNPs (1) treatment respect to A. arborescens-AgNPs (2), and AgNPs (3) derived from a classical chemical synthesis. Moreover, after 24 and 48 hours of A. abrotanum-AgNPs (1) treatment, the parasite growth was locked in the ring stage, evidencing the effect of these nanoparticles to hinder the maturation of P. falciparum. The anti-malarial ac

Journal article

Pinna A, Cali E, Kerherve G, Galleri G, Maggini M, Innocenzi P, Malfatti Let al., 2020, Fulleropyrrolidine-functionalized ceria nanoparticles as a tethered dual nanosystem with improved antioxidant properties, Nanoscale Advances, Vol: 2, Pages: 2387-2396, ISSN: 2516-0230

Dual-tethered nanosystems which combine different properties at the nano scale represent a new fascinating frontier of research. In the present work, we present an example of a dual nanosystem designed to enhance the radical scavenging performances. Fulleropyrrolidine has been bonded to cerium oxide nanoparticles (nanoceria) to form a dual tethered system. Fulleropyrrolidine, bearing a silyl-alkoxide group, has been chemically bonded to the nanoceria surface, providing unprecedented antioxidant activity. This effect has been evaluated using an L929 mouse fibroblast cell line exposed to UV light. The fulleropyrrolidine molecules tethered to nanoceria enhance the radical scavenging properties of the oxide. At the same time, fulleropyrrolidine mitigates the potential toxicity of nanoceria at high doses. On the other hand, cerium oxide nanoparticles provide a strong hydrophilicity to the dual nanosystem, ensuring the administration in a cellular environment and preventing macroscopic aggregation of fulleropyrrolidine. The rational assembly of two different components in one nanosystem appears as a promising route for the development of “smarter” medical and cosmetic devices.

Journal article

Mohammed AA, Pinna A, Li S, Sang T, Jones JRet al., 2020, Auto-catalytic redox polymerisation using nanoceria and glucose oxidase for double network hydrogels, Journal of Materials Chemistry B, Vol: 8, Pages: 2834-2844, ISSN: 2050-750X

A novel auto-catalytic reaction, a combination of naturally occurring enzyme glucose oxidase (GOx) and amine-functionalised cerium oxide nanoparticles (nanoceria), was employed for open vessel free radical polymerisation of double network hydrogels (DNHGs). The nanoceria also incorporated into the gels to enhance mechanical strength. GOx reduces atmospheric O2 to H2O2, causing a cyclic change of cerium ion states, resulting in propagating free radicals in the carbon group in the amino functionalised nanoceria surface. We synthesised novel nanocomposite DNHGs by grafting polymers onto amine-functionalised nanoceria (ANC), with poly(2-acrylamido-2-methylpropanesulfonic acid), PAMPS, and polyacrylamide (PAAm) in the first and second networks respectively. The graft polymerisation was initiated using the alternating cerium states on the ANC. GOx held two major roles within the reaction: to provide an oxygen free system, without any other form of degassing, and to provide cyclical cerium ion states between Ce4+ and Ce3+, creating new free radicals for polymerisation. Polymer conversion using ANC as the sole initiator in the presence of GOx resulted in 83% conversion for PAMPS and 64% PAAm. Polymers degassed only with argon resulted in less than 55% conversion for both PAAm and PAMPS, proving that the addition of GOx enhanced the reaction. The new gels (1.76 MPa) showed an order of magnitude improvement in mechanical properties compared to DNHG made without ANC/GOx (0.10 MPa).

Journal article

Ravanbakhsh M, Labbaf S, Karimzadeh F, Pinna A, Houreh AB, Nasr-Esfahani MHet al., 2019, Mesoporous bioactive glasses for the combined application of osteosarcoma treatment and bone regeneration, Materials Science and Engineering C: Materials for Biological Applications, Vol: 104, Pages: 1-10, ISSN: 0928-4931

In this study, mesoporous bioactive glass (MBG) sub-micro particles were prepared through sol-gel synthesis and possessed a uniform and spherical structure with particle size of 302 ± 43 nm, a pore size of 4 nm and a high surface area of 354 m2 g−1. Alendronate (AL) is often used for the treatment of bone associated diseases, in particular osteosarcoma. However, due to the low bioavailability and high toxicity at increased doses, local and sustained release would be an ideal approach to AL delivery. Here, MBGs and aminated MBGs (AMBG) were applied as carriers for AL loading. High encapsulation efficiency of 75% and 85% and loading efficiency of 60% and 63%, for MBG and AMBG, respectively, was achieved. The release profile of AL from AMBG showed a better sustained and controlled release mechanism compared to MBG. In vitro results demonstrated the non-cytotoxic nature of both MBG and AMBG following exposure to MG63 osteoblast like cell line. AL release from MBG and AMBG, even at lower concentration, provoked decreased MG63 proliferation. The osteogenic potential of MBG and AMBG following exposure to dental pulp stem cells was evaluated using alizarin red assay.

Journal article

Pinna A, Ricco R, Migheli R, Rocchitta G, Serra PA, Falcaro P, Malfatti L, Innocenzi Pet al., 2018, A MOF-based carrier for in situ dopamine delivery, RSC Advances: an international journal to further the chemical sciences, Vol: 8, Pages: 25664-25672, ISSN: 2046-2069

MIL-88A (Fe) MOF crystals were nucleated and grown around a polymer core containing superparamagnetic nanoparticles to assemble a new class of biocompatible particles for magnetophoretic drug delivery of dopamine. The carrier enabled efficient targeted release, dopamine protection from oxidative damage, long-term delivery and improved drug delivery cost-efficiency. After loading, dopamine was stable within the carrier and did not undergo oxidation. Drug release monitoring via spectrofluorimetry revealed a shorter burst effect and higher release efficiency than silica based carriers. The in vitro cytotoxicity at different MOF concentrations and sizes was assessed using PC12 cells as the neuronal cell model. The drug was directly uptaken into the PC12 cells avoiding possible side effects due to oxidation occurring in the extracellular environment.

Journal article

Falchi L, Galleri G, Dore GM, Zedda MT, Pau S, Bogliolo L, Ariu F, Pinna A, Nieddu S, Innocenzi P, Ledda Set al., 2018, Effect of exposure to CeO2 nanoparticles on ram spermatozoa during storage at 4 degrees C for 96 hours, Reproductive Biology and Endocrinology, Vol: 16, ISSN: 1477-7827

BackgroundCerium oxide nanoparticles (CeO2 NPs) are able to store and release oxygen, conferring them scavenger activity against oxidative stress. However, their effects in reproductive systems are not yet well understood. The aim of the study was to investigate the effects of exposure of refrigerated ram semen to CeO2 NPs for 96 h on the main structural and kinematic parameters of spermatozoa.MethodsThe ejaculates of 5 Sarda rams were collected, pooled and diluted in a soybean lecithin extender. Samples were exposed to increasing doses of CeO2 NPs (0, 44 and 220 μg/mL) and stored at 4 °C for 96 h. Analyses of kinematic parameters (computer assisted sperm analysis, CASA), integrity of membranes (PI/PSA staining), ROS production (H2DCFDA staining) and DNA damage (sperm chromatin structure assay with acridine orange, SCSA) were performed every 24 h (0, 24, 48, 72 and 96 h of incubation). The experiment was carried out in 6 replicates. Data were analysed by repeated measures ANOVA with Bonferroni’s as post hoc test. When the assumption of normality was not met (ROS), non-parametric Kruskal-Wallis rank test was carried out.ResultsExposure of ram spermatozoa to increasing doses of CeO2 NPs had a beneficial effect on the main motility parameters from 48 h of incubation onward. Velocity of sperm cells was enhanced in the groups exposed to CeO2 NPs compared to the control. Incubation with NPs had beneficial effects on the integrity of plasma membranes of spermatozoa, with higher percentage of damaged cells in the control group compared to the exposed ones. Production of ROS was not affected by exposure to NPs and its levels rose at 96 h of incubation. The integrity of DNA remained stable throughout the 96 h of storage regardless of co-incubation with NPs.ConclusionsWe reported beneficial effects of CeO2 NPs on kinematic and morphologic parameters of ram semen, such as motility and membrane integrity following 96 h of exposure. Furthermore, we also proved no gen

Journal article

Nommeots-Nomm A, Labbaf S, Devlin A, Todd N, Geng H, Solanki A, Tang H, Perdika P, Pinna A, Ejeian F, Tsigkou O, Lee PD, Esfahani MHN, Mitchell CA, Jones JRet al., 2017, Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration, Acta Biomaterialia, Vol: 57, Pages: 449-461, ISSN: 1878-7568

A challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnected pores while maintaining the amorphous nature of the glass and its associated bioactivity. Here we introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silica content and report in vitro and preliminary in vivo data. The gel-cast foaming process was adapted, employing temperature controlled gelation of gelatin, rather than the in situ acrylic polymerisation used previously. To form a 3D construct from melt derived glasses, particles must be fused via thermal processing, termed sintering. The original Bioglass® 45S5 composition crystallises upon sintering, altering its bioactivity, due to the temperature difference between the glass transition temperature and the crystallisation onset being small. Here, we optimised and compared scaffolds from three glass compositions, ICIE16, PSrBG and 13–93, which were selected due to their widened sintering windows. Amorphous scaffolds with modal pore interconnect diameters between 100–150 µm and porosities of 75% had compressive strengths of 3.4 ± 0.3 MPa, 8.4 ± 0.8 MPa and 15.3 ± 1.8 MPa, for ICIE16, PSrBG and 13–93 respectively. These porosities and compressive strength values are within the range of cancellous bone, and greater than previously reported foamed scaffolds. Dental pulp stem cells attached to the scaffold surfaces during in vitro culture and were viable. In vivo, the scaffolds were found to regenerate bone in a rabbit model according to X-ray micro tomography imaging.

Journal article

Ariu F, Bogliolo L, Pinna A, Malfatti L, Innocenzi P, Falchi L, Bebbere D, Ledda Set al., 2017, Cerium oxide nanoparticles (CeO2 NPs) improve the developmental competence of in vitro-matured prepubertal ovine oocytes, REPRODUCTION FERTILITY AND DEVELOPMENT, Vol: 29, Pages: 1046-1056, ISSN: 1031-3613

Journal article

Malfatti L, Carboni D, Pinna A, Lasio B, Marmiroli B, Innocenzi Pet al., 2016, In situ growth of Ag nanoparticles in graphene-TiO2 mesoporous films induced by hard X-ray, Journal of Sol-Gel Science and Technology, Vol: 79, Pages: 295-302, ISSN: 0928-0707

The controlled growth of Ag nanoparticles into graphene–TiO2 mesoporous films has been triggered by hard X-ray exposure provided by a synchrotron storage ring. The kinetic process has been studied by UV–visible spectroscopy as a function of the X-ray dose and compared to the nanoparticle growth induced in a bare mesoporous titania matrix. The graphene layers act as a preferential nucleation sites, allowing a faster nucleation of the nanoparticles. Moreover, the growth of larger nanoparticles is also promoted as a function of the exposure dose. The combined bottom-up and top-down approach to fabricate nanocomposites porous films embedding both graphene and plasmonic nanoparticles is expected to be a fundamental tool for the design of new analytical platforms based on the enhancement of the Raman signals.

Journal article

Jiang Y, Carboni D, Pinna A, Marmiroli B, Malfatti L, Innocenzi Pet al., 2016, Hard X-rays for processing hybrid organic-inorganic thick films., Journal of Synchrotron Radiation, Vol: 23, Pages: 267-273, ISSN: 1600-5775

Hard X-rays, deriving from a synchrotron light source, have been used as an effective tool for processing hybrid organic-inorganic films and thick coatings up to several micrometres. These coatings could be directly modified, in terms of composition and properties, by controlled exposure to X-rays. The physico-chemical properties of the coatings, such as hardness, refractive index and fluorescence, can be properly tuned using the interaction of hard X-rays with the sol-gel hybrid films. The changes in the microstructure have been correlated especially with the modification of the optical and the mechanical properties. A relationship between the degradation rate of the organic groups and the rise of fluorescence from the hybrid material has been observed; nanoindentation analysis of the coatings as a function of the X-ray doses has shown a not linear dependence between thickness and film hardness.

Journal article

Vacca A, Mascia M, Mais L, Delogu F, Palmas S, Pinna Aet al., 2016, Electrodeposition of Zirconium from 1-Butyl-1-Methylpyrrolidinium-Bis(Trifluoromethylsulfonyl)imide: Electrochemical Behavior and Reduction Pathway, MATERIALS AND MANUFACTURING PROCESSES, Vol: 31, Pages: 74-80, ISSN: 1042-6914

Journal article

Falchi L, Bogliolo L, Galleri G, Ariu F, Zedda MT, Pinna A, Malfatti L, Innocenzi P, Ledda Set al., 2015, Cerium dioxide nanoparticles did not alter the functional and morphologic characteristics of ram sperm during short-term exposure, Theriogenology, Vol: 85, Pages: 1274-1281.e3, ISSN: 0093-691X

The aim of the study was to investigate the interaction and the short-term effects of increasing doses of cerium dioxide nanoparticles (CeO2 NPs) on ram spermatozoa, stored at 4 °C for up to 24 hours, on the main functional and kinematic parameters. Spermatozoa were incubated with 0, 22, 44, and 220 μg/mL of CeO2 NPs at 4 °C and submitted at 0, 2, and 24 hours to the following analyses: (1) intracellular uptake of CeO2 NPs by the spermatozoa; (2) kinematic parameters; (3) acrosome and membrane integrity; (4) integrity of DNA; (5) mitochondrial activity; (6) ROS production. The results indicated that the exposure of spermatozoa to increasing doses of nanoceria was well tolerated. No intracellular uptake of NPs by the cells was observed and both kinematic parameters and status of the membranes were not affected by the incubation with NPs (P > 0.05). Moreover, no influence on the redox status of spermatozoa and on the levels of fragmentation of DNA was reported among groups at any time (P > 0.05). The data collected provide new information about the impact of CeO2 NPs on the male gamete in large animal model and could open future perspectives about their biomedical use in the assisted reproductive techniques.

Journal article

Pinna A, Malfatti L, Galleri G, Manetti R, Cossu S, Rocchitta G, Migheli R, Serra PA, Innocenzi Pet al., 2015, Ceria nanoparticles for the treatment of Parkinson-like diseases induced by chronic manganese intoxication, RSC Advances: an international journal to further the chemical sciences, Vol: 5, Pages: 20432-20439, ISSN: 2046-2069

Ceria nanoparticles with controlled size have been studied as antioxidant agents for the in vitro protection of catecholaminergic cells (PC12) exposed to manganese, which is responsible for an occupational form of Parkinson-like disease. The nanoparticle internalization has been followed by Raman and confocal microscopy while the effect of nanoceria concentration in the cell metabolism has been assessed by MTT and trypan blue assay. With the perspective to develop an innovative combined treatment, nanoceria has been tested either alone or in association with L-DOPA showing a significant effect in reducing the oxidative stress due to manganese chloride. Finally, to study the protective role of nanoceria on the metabolism of catecholamines, the intracellular concentration of dopamine and its metabolites have been monitored by liquid chromatography with electro-chemical detection in control and nanoparticle-exposed cells as a function of the nanoceria dosing. The results show a protective role of nanoceria both on PC12 cells survival and dopamine metabolism, which makes this class of nanoparticles a potential candidate for the treatment of Parkinson-like diseases induced by chronic manganese intoxication.

Journal article

Malfatti L, Pinna A, Enzo S, Falcaro P, Marmiroli B, Innocenzi Pet al., 2015, Tuning the phase transition of ZnO thin films through lithography: an integrated bottom-up and top-down processing, JOURNAL OF SYNCHROTRON RADIATION, Vol: 22, Pages: 165-171, ISSN: 0909-0495

Journal article

Carboni D, Pinna A, Amenitsch H, Casula MF, Loche D, Malfatti L, Innocenzi Pet al., 2015, Getting order in mesostructured thin films, from pore organization to crystalline walls, the case of 3-glycidoxypropyltrimethoxysilane, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 17, Pages: 10679-10686, ISSN: 1463-9076

Journal article

Innocenzi P, Malfatti L, Lasio B, Pinna A, Loche D, Casula MF, Alzari V, Mariani Aet al., 2014, Sol-gel chemistry for graphene-silica nanocomposite films, NEW JOURNAL OF CHEMISTRY, Vol: 38, Pages: 3777-3782, ISSN: 1144-0546

Journal article

Falcaro P, Trinchi A, Doherty C, Buso D, Costacurta S, Hill AJ, Patelli A, Scopece P, Marmiroli B, Amenistch H, Lasio B, Pinna A, Innocenzi P, Malfatti Let al., 2014, 3D Spatially Controlled Chemical Functionalization on Alumina Membranes, SCIENCE OF ADVANCED MATERIALS, Vol: 6, Pages: 1520-1524, ISSN: 1947-2935

Journal article

Pinna A, Lasio B, Carboni D, Marceddu S, Malfatti L, Innocenzi Pet al., 2014, Engineering the surface of hybrid organic-inorganic films with orthogonal grafting of oxide nanoparticles, JOURNAL OF NANOPARTICLE RESEARCH, Vol: 16, ISSN: 1388-0764

Journal article

Carboni D, Marongiu D, Rassu P, Pinna A, Amenitsch H, Casula M, Marcelli A, Cibin G, Falcaro P, Malfatti L, Innocenzi Pet al., 2014, Enhanced Photocatalytic Activity in Low-Temperature Processed Titania Mesoporous Films, JOURNAL OF PHYSICAL CHEMISTRY C, Vol: 118, Pages: 12000-12009, ISSN: 1932-7447

Journal article

Malfatti L, Falcaro P, Pinna A, Lasio B, Casula MF, Loche D, Falqui A, Marmiroli B, Amenitsch H, Sanna R, Mariani A, Innocenzi Pet al., 2014, Exfoliated Graphene into Highly Ordered Mesoporous Titania Films: Highly Performing Nanocomposites from Integrated Processing, ACS APPLIED MATERIALS & INTERFACES, Vol: 6, Pages: 795-802, ISSN: 1944-8244

Journal article

Carboni D, Pinna A, Malfatti L, Innocenzi Pet al., 2014, Smart tailoring of the surface chemistry in GPTMS hybrid organic-inorganic films, NEW JOURNAL OF CHEMISTRY, Vol: 38, Pages: 1635-1640, ISSN: 1144-0546

Journal article

Pinna A, Lasio B, Piccinini M, Marmiroli B, Amenitsch H, Falcaro P, Tokudome Y, Malfatti L, Innocenzi Pet al., 2013, Combining Top-Down and Bottom-Up Routes for Fabrication of Mesoporous Titania Films Containing Ceria Nanoparticles for Free Radical Scavenging, ACS APPLIED MATERIALS & INTERFACES, Vol: 5, Pages: 3168-3175, ISSN: 1944-8244

Journal article

Carboni D, Malfatti L, Pinna A, Lasio B, Tokudome Y, Takahashi M, Innocenzi Pet al., 2013, Molecularly imprinted La-doped mesoporous titania films with hydrolytic properties toward organophosphate pesticides, NEW JOURNAL OF CHEMISTRY, Vol: 37, Pages: 2995-3002, ISSN: 1144-0546

Journal article

Pinna A, Figus C, Lasio B, Piccinini M, Malfatti L, Innocenzi Pet al., 2012, Release of Ceria Nanoparticles Grafted on Hybrid Organic-Inorganic Films for Biomedical Application, ACS APPLIED MATERIALS & INTERFACES, Vol: 4, Pages: 3916-3922, ISSN: 1944-8244

Journal article

Pinna A, Malfatti L, Piccinini M, Falcaro P, Innocenzi Pet al., 2012, Hybrid materials with an increased resistance to hard X-rays using fullerenes as radical sponges, JOURNAL OF SYNCHROTRON RADIATION, Vol: 19, Pages: 586-590, ISSN: 0909-0495

Journal article

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