Imperial College London
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DrAlessandraPinna

Faculty of Engineering, Department of Materials

Honorary Senior Research Fellow
 
 
 
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Contact

 

a.pinna

 
 
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Location

 

2M14Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ravanbakhsh:2019:10.1016/j.msec.2019.109994,
author = {Ravanbakhsh, M and Labbaf, S and Karimzadeh, F and Pinna, A and Houreh, AB and Nasr-Esfahani, MH},
doi = {10.1016/j.msec.2019.109994},
journal = {Materials Science and Engineering C: Materials for Biological Applications},
pages = {1--10},
title = {Mesoporous bioactive glasses for the combined application of osteosarcoma treatment and bone regeneration},
url = {http://dx.doi.org/10.1016/j.msec.2019.109994},
volume = {104},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In this study, mesoporous bioactive glass (MBG) sub-micro particles were prepared through sol-gel synthesis and possessed a uniform and spherical structure with particle size of 302±43nm, a pore size of 4nm and a high surface area of 354 m2g−1. Alendronate (AL) is often used for the treatment of bone associated diseases, in particular osteosarcoma. However, due to the low bioavailability and high toxicity at increased doses, local and sustained release would be an ideal approach to AL delivery. Here, MBGs and aminated MBGs (AMBG) were applied as carriers for AL loading. High encapsulation efficiency of 75% and 85% and loading efficiency of 60% and 63%, for MBG and AMBG, respectively, was achieved. The release profile of AL from AMBG showed a better sustained and controlled release mechanism compared to MBG. In vitro results demonstrated the non-cytotoxic nature of both MBG and AMBG following exposure to MG63 osteoblast like cell line. AL release from MBG and AMBG, even at lower concentration, provoked decreased MG63 proliferation. The osteogenic potential of MBG and AMBG following exposure to dental pulp stem cells was evaluated using alizarin red assay.
AU  - Ravanbakhsh,M
AU  - Labbaf,S
AU  - Karimzadeh,F
AU  - Pinna,A
AU  - Houreh,AB
AU  - Nasr-Esfahani,MH
DO  - 10.1016/j.msec.2019.109994
EP  - 10
PY  - 2019///
SN  - 0928-4931
SP  - 1
TI  - Mesoporous bioactive glasses for the combined application of osteosarcoma treatment and bone regeneration
T2  - Materials Science and Engineering C: Materials for Biological Applications
UR  - http://dx.doi.org/10.1016/j.msec.2019.109994
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000487569300117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0928493118328716?via%3Dihub
VL  - 104
ER  -
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