Imperial College London
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DrAlessandraPinna

Faculty of Engineering, Department of Materials

Honorary Senior Research Fellow
 
 
 
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a.pinna

 
 
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Location

 

2M14Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Avitabile:2020:10.1371/journal.pone.0238532,
author = {Avitabile, E and Senes, N and D'Avino, C and Tsamesidis, I and Pinna, A and Medici, S and Pantaleo, A},
doi = {10.1371/journal.pone.0238532},
journal = {PLoS One},
pages = {1--17},
title = {The potential antimalarial efficacy of hemocompatible silver nanoparticles fromArtemisiaspecies againstP.falciparumparasite},
url = {http://dx.doi.org/10.1371/journal.pone.0238532},
volume = {15},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Malaria represents one of the most common infectious diseases which becoming an impellent public health problem worldwide. Antimalarial classical medications include quinine-based drugs, like chloroquine, and artesunate, a derivative of artemisinin, a molecule found in the plant Artemisia annua. Such therapeutics are very effective but show heavy side effects like drug resistance. In this study, “green” silver nanoparticles (AgNPs) have been prepared from two Artemisia species (A. abrotanum and A. arborescens), traditionally used in folk medicine as a remedy for different conditions, and their potential antimalarial efficacy have been assessed. AgNPs have been characterized by UV-Vis, dynamic light scattering and zeta potential, FTIR, XRD, TEM and EDX. The structural characterization has demonstrated the spheroidal shape of nanoparticles and dimensions under 50 nm, useful for biomedical studies. Zeta potential analysis have shown the stability and dispersion of green AgNPs in aqueous medium without aggregation. AgNPs hemocompatibility and antimalarial activity have been studied in Plasmodium falciparum cultures in in vitro experiments. The antiplasmodial effect has been assessed using increasing doses of AgNPs (0.6 to 7.5 μg/mL) on parasitized red blood cells (pRBCs). Obtained data showed that the hemocompatibility of AgNPs is related to their synthetic route and depends on the administered dose. A. abrotanum-AgNPs (1) have shown the lowest percentage of hemolytic activity on pRBCs, underlining their hemocompatibility. These results are in accordance with the lower levels of parasitemia observed after A. abrotanum-AgNPs (1) treatment respect to A. arborescens-AgNPs (2), and AgNPs (3) derived from a classical chemical synthesis. Moreover, after 24 and 48 hours of A. abrotanum-AgNPs (1) treatment, the parasite growth was locked in the ring stage, evidencing the effect of these nanoparticles to hinder the maturation of P. falciparum. The anti-malarial ac
AU  - Avitabile,E
AU  - Senes,N
AU  - D'Avino,C
AU  - Tsamesidis,I
AU  - Pinna,A
AU  - Medici,S
AU  - Pantaleo,A
DO  - 10.1371/journal.pone.0238532
EP  - 17
PY  - 2020///
SN  - 1932-6203
SP  - 1
TI  - The potential antimalarial efficacy of hemocompatible silver nanoparticles fromArtemisiaspecies againstP.falciparumparasite
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0238532
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000568872300023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238532
UR  - http://hdl.handle.net/10044/1/84516
VL  - 15
ER  -
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