Imperial College London
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DrAlessandraPinna

Faculty of Engineering, Department of Materials

Honorary Senior Research Fellow
 
 
 
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Contact

 

a.pinna

 
 
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Location

 

2M14Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pinna:2015:10.1039/c4ra16265j,
author = {Pinna, A and Malfatti, L and Galleri, G and Manetti, R and Cossu, S and Rocchitta, G and Migheli, R and Serra, PA and Innocenzi, P},
doi = {10.1039/c4ra16265j},
journal = {RSC Advances: an international journal to further the chemical sciences},
pages = {20432--20439},
title = {Ceria nanoparticles for the treatment of Parkinson-like diseases induced by chronic manganese intoxication},
url = {http://dx.doi.org/10.1039/c4ra16265j},
volume = {5},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ceria nanoparticles with controlled size have been studied as antioxidant agents for the in vitro protection of catecholaminergic cells (PC12) exposed to manganese, which is responsible for an occupational form of Parkinson-like disease. The nanoparticle internalization has been followed by Raman and confocal microscopy while the effect of nanoceria concentration in the cell metabolism has been assessed by MTT and trypan blue assay. With the perspective to develop an innovative combined treatment, nanoceria has been tested either alone or in association with L-DOPA showing a significant effect in reducing the oxidative stress due to manganese chloride. Finally, to study the protective role of nanoceria on the metabolism of catecholamines, the intracellular concentration of dopamine and its metabolites have been monitored by liquid chromatography with electro-chemical detection in control and nanoparticle-exposed cells as a function of the nanoceria dosing. The results show a protective role of nanoceria both on PC12 cells survival and dopamine metabolism, which makes this class of nanoparticles a potential candidate for the treatment of Parkinson-like diseases induced by chronic manganese intoxication.
AU  - Pinna,A
AU  - Malfatti,L
AU  - Galleri,G
AU  - Manetti,R
AU  - Cossu,S
AU  - Rocchitta,G
AU  - Migheli,R
AU  - Serra,PA
AU  - Innocenzi,P
DO  - 10.1039/c4ra16265j
EP  - 20439
PY  - 2015///
SN  - 2046-2069
SP  - 20432
TI  - Ceria nanoparticles for the treatment of Parkinson-like diseases induced by chronic manganese intoxication
T2  - RSC Advances: an international journal to further the chemical sciences
UR  - http://dx.doi.org/10.1039/c4ra16265j
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350220400075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 5
ER  -
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