Imperial College London
Alternate

ProfessorAlexandraPorter

Faculty of Engineering, Department of Materials

Professor of Bio-imaging and Analysis
 
 
 
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Contact

 

+44 (0)20 7594 9691a.porter

 
 
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Location

 

B341 Royal School of MinesRoyal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chen:2020:10.1016/j.mtadv.2020.100066,
author = {Chen, S and Greasley, SL and Ong, ZY and Naruphontjirakul, P and Page, SJ and Hanna, J and Redpath, AN and Tsigkou, O and Rankin, S and Ryan, MP and Porter, AE and Jones, JR},
doi = {10.1016/j.mtadv.2020.100066},
journal = {Materials Today},
pages = {1--11},
title = {Biodegradable zinc-containing mesoporous silica nanoparticles for cancer therapy},
url = {http://dx.doi.org/10.1016/j.mtadv.2020.100066},
volume = {6},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Triple-negative breast cancers are extremely aggressive with limited treatment options because of the reduced response of the cancerous cells to hormonal therapy. Here, monodispersed zinc-containing mesoporous silica nanoparticles (MSNPs-Zn) were produced as a tuneable biodegradable platform for delivery of therapeutic zinc ions into cells. We demonstrate that the nanoparticles were internalized by cells, and a therapeutic dose window was identified in which the MSNPs-Zn were toxic to breast cancer cells but not to healthy epithelial (MCF-10a) cells or to murine macrophages. A significant reduction in the viability of triple negative MDA-MB-231 and MCF-7 (ER+) breast cancer cells was seen following 24 h exposure to MSNPs-Zn. The more aggressive MDA-MB-231 cells, with higher metastatic potential, were more sensitive to MSNPs-Zn than the MCF-7 cells. MSNPs-Zn underwent biodegradation inside the cells, becoming hollow structures, as imaged by high-resolution transmission electron microscopy. The mesoporous silica nanoparticles provide a biodegradable vehicle for therapeutic ion release inside cells.
AU  - Chen,S
AU  - Greasley,SL
AU  - Ong,ZY
AU  - Naruphontjirakul,P
AU  - Page,SJ
AU  - Hanna,J
AU  - Redpath,AN
AU  - Tsigkou,O
AU  - Rankin,S
AU  - Ryan,MP
AU  - Porter,AE
AU  - Jones,JR
DO  - 10.1016/j.mtadv.2020.100066
EP  - 11
PY  - 2020///
SN  - 1369-7021
SP  - 1
TI  - Biodegradable zinc-containing mesoporous silica nanoparticles for cancer therapy
T2  - Materials Today
UR  - http://dx.doi.org/10.1016/j.mtadv.2020.100066
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000536739700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S2590049820300138?via%3Dihub
UR  - http://hdl.handle.net/10044/1/80666
VL  - 6
ER  -
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