Publications
274 results found
Rockall AG, Qureshi M, Papadopoulou I, et al., 2016, Role of Imaging in Fertility-sparing Treatment of Gynecologic Malignancies, RADIOGRAPHICS, Vol: 36, Pages: 2214-2233, ISSN: 0271-5333
Glocker B, Konukoglu E, Lavdas I, et al., 2016, Correction of Fat-Water Swaps in Dixon MRI, 19th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2016), Publisher: Springer Verlag, ISSN: 0302-9743
The Dixon method is a popular and widely used technique for fat-water separation in magnetic resonance imaging, and today, nearly all scanner manufacturers are offering a Dixon-type pulse sequence that produces scans with four types of images: in-phase, out-of-phase, fat-only, and water-only. A natural ambiguity due to phase wrapping and local minima in the optimization problem cause a frequent artifact of fat-water inversion where fat- and water-only voxel values are swapped. This artifact affects up to 10 % of routinely acquired Dixon images, and thus, has severe impact on subsequent analysis. We propose a simple yet very effective method, Dixon-Fix, for correcting fat-water swaps. Our method is based on regressing fat- and water-only images from in- and out-of-phase images by learning the conditional distribution of image appearance. The predicted images define the unary potentials in a globally optimal maximum-a-posteriori estimation of the swap labeling with spatial consistency. We demonstrate the effectiveness of our approach on whole-body MRI with various types of fat-water swaps.
Dubash SR, Keat N, Mapelli P, et al., 2016, Biodistribution, radiation dosimetry and first preliminary results of a novel <SUP>18</SUP>F-fluoroethyl triazole [Tyr<SUP>3</SUP>] octreotate analogue for PET imaging in locally advanced and metastatic Neuroendocrine tumour patients, Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S105-S105, ISSN: 1619-7070
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- Citations: 1
Koh D-M, Kaste SC, Vinnicombe SJ, et al., 2016, Proceedings of the International Cancer Imaging Society (ICIS) 16th Annual Teaching Course, Cancer Imaging, Vol: 16
Querleu D, Planchamp F, Chiva L, et al., 2016, European Society of Gynaecologic Oncology Quality Indicators for Advanced Ovarian Cancer Surgery, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 26, Pages: 1354-1363, ISSN: 1048-891X
Nasser S, Lazaridis A, Evangelou M, et al., 2016, Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer: A retrospective evaluation, Gynecologic Oncology, Vol: 143, Pages: 264-269, ISSN: 1095-6859
ObjectivesComputed tomography (CT) is an essential part of preoperative planning prior to cytoreductive surgery for primary and relapsed epithelial ovarian cancer (EOC). Our aim is to correlate pre-operative CT results with intraoperative surgical and histopathological findings at debulking surgery.MethodsWe performed a systematic comparison of intraoperative tumor dissemination patterns and surgical resections with preoperative CT assessments of infiltrative disease at key resection sites, in women who underwent multivisceral debulking surgery due to EOC between January 2013 and December 2014 at a tertiary referral center. The key sites were defined as follows: diaphragmatic involvement(DI), splenic disease (SI), large (LBI) and small (SBI) bowel involvement, rectal involvement (RI), porta hepatis involvement (PHI), mesenteric disease (MI) and lymph node involvement (LNI).ResultsA total of 155 patients, mostly with FIGO stage IIIC disease (65%) were evaluated (primary = 105, relapsed = 50). Total macroscopic cytoreduction rates were: 89%. Pre-operative CT findings displayed high specificity across all tumor sites apart from the retroperitoneal lymph node status, with a specificity of 65%.The ability however of the CT to accurately identify sites affected by invasive disease was relatively low with the following sensitivities as relating to final histology:32% (DI), 26% (SI), 46% (LBI), 44% (SBI), 39% (RI), 57% (PHI), 31% (MI), 63% (LNI).ConclusionPre-operative CT imaging shows high specificity but low sensitivity in detecting tumor involvement at key sites in ovarian cancer surgery. CT findings alone should not be used for surgical decision making.
Khan SR, Rockall AG, Barwick TD, 2016, Molecular imaging in cervical cancer, QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 60, Pages: 77-92, ISSN: 1824-4785
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- Citations: 21
Beranger-Gibert S, Sakly H, Ballester M, et al., 2016, Diagnostic Value of MR Imaging in the Diagnosis of Adnexal Torsion, RADIOLOGY, Vol: 279, Pages: 461-470, ISSN: 0033-8419
Raithatha A, Papadopoulou I, Stewart V, et al., 2016, Cervical Cancer Staging: A Resident's Primer: Women's Imaging., Radiographics, Vol: 36, Pages: 933-934
Papadopoulou I, Stewart V, Barwick TD, et al., 2016, Post-Radiation Therapy Imaging Appearances in Cervical Carcinoma, RADIOGRAPHICS, Vol: 36, Pages: 538-553, ISSN: 0271-5333
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- Citations: 23
desouza NM, Rockall A, Freeman S, 2016, Functional MR Imaging in Gynecologic Cancer, MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA, Vol: 24, Pages: 205-+, ISSN: 1064-9689
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- Citations: 15
Cuthbert F, Bharwani N, Masselli G, et al., 2016, MR of gynaecologic disease in pregnancy, MRI of Fetal and Maternal Diseases in Pregnancy, Pages: 397-415, ISBN: 9783319214276
MR imaging to investigate gynaecologic pathology in pregnancy typically follows clinical and US assessment, and there is usually a provisional diagnosis that requires further imaging assessment for confirmation. The MR examination can be tailored to the clinical question in order to limit scan time and improve diagnostic yield. Gynaecologic disease may be pre-existing, incidentally detected or occur as a result of pregnancy. We review normal MR appearances of the uterus, cervix and adnexa and then discuss MR appearances of a wide variety of interesting and complex scenarios including – cervical cancer in pregnancy, adnexal masses, uterine fibroids and their complications and finally a discussion of rarer presentations including gestational trophoblastic neoplasia. MR is a useful problem-solving tool in the evaluation of gynaecologic pathology in pregnant women.
Winfield JM, Collins DJ, Priest AN, et al., 2016, A framework for optimization of diffusion-weighted MRI protocols for large field-of-view abdominal-pelvic imaging in multicenter studies., Medical Physics, Vol: 43, Pages: 95-110, ISSN: 0094-2405
PURPOSE: To develop methods for optimization of diffusion-weighted MRI (DW-MRI) in the abdomen and pelvis on 1.5 T MR scanners from three manufacturers and assess repeatability of apparent diffusion coefficient (ADC) estimates in a temperature-controlled phantom and abdominal and pelvic organs in healthy volunteers. METHODS: Geometric distortion, ghosting, fat suppression, and repeatability and homogeneity of ADC estimates were assessed using phantoms and volunteers. Healthy volunteers (ten per scanner) were each scanned twice on the same scanner. One volunteer traveled to all three institutions in order to provide images for qualitative comparison. The common volunteer was excluded from quantitative analysis of the data from scanners 2 and 3 in order to ensure statistical independence, giving n = 10 on scanner 1 and n = 9 on scanners 2 and 3 for quantitative analysis. Repeatability and interscanner variation of ADC estimates in kidneys, liver, spleen, and uterus were assessed using within-patient coefficient of variation (wCV) and Kruskal-Wallis tests, respectively. RESULTS: The coefficient of variation of ADC estimates in the temperature-controlled phantom was 1%-4% for all scanners. Images of healthy volunteers from all scanners showed homogeneous fat suppression and no marked ghosting or geometric distortion. The wCV of ADC estimates was 2%-4% for kidneys, 3%-7% for liver, 6%-9% for spleen, and 7%-10% for uterus. ADC estimates in kidneys, spleen, and uterus showed no significant difference between scanners but a significant difference was observed in liver (p < 0.05). CONCLUSIONS: DW-MRI protocols can be optimized using simple phantom measurements to produce good quality images in the abdomen and pelvis at 1.5 T with repeatable quantitative measurements in a multicenter study.
Lakhani A, Khan S, Bharwani N, et al., 2015, FDG-PET/CT pitfalls in gynecological and genitourinary oncological imaging, Cancer Imaging, Vol: 15
Lakhani A, Barwick T, Gedroyc W, et al., 2015, Tractography of the prostatic neurovascular bundles: technique and interpretation, Cancer Imaging, Vol: 15
Papadopoulou I, Qureshi M, Butterfield N, et al., 2015, Fertility preservation in gynaecologic malignancy: imaging role in treatment planning, Cancer Imaging, Vol: 15
Cuthbert F, Bharwani N, Rockall A, 2015, Detection of gynaecological cancer in pregnancy, Cancer Imaging, Vol: 15
Nasser S, Lazaridis A, Jones B, et al., 2015, CORRELATION OF PRE-OPERATIVE CT FINDINGS WITH SURGICAL & HISTOLOGICAL TUMOR DISSEMINATION PATTERNS AT CYTOREDUCTION FOR ADVANCED OVARIAN CANCER: A RETROSPECTIVE EVALUATION, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 25, Pages: 502-502, ISSN: 1048-891X
Lavdas I, Rockall AG, Castelli F, et al., 2015, Apparent Diffusion Coefficient of Normal Abdominal Organs and Bone Marrow From Whole-Body DWI at 1.5 T: The Effect of Sex and Age, AMERICAN JOURNAL OF ROENTGENOLOGY, Vol: 205, Pages: 242-250, ISSN: 0361-803X
Caplin ME, Baudin E, Ferolla P, et al., 2015, Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids, ANNALS OF ONCOLOGY, Vol: 26, Pages: 1604-1620, ISSN: 0923-7534
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- Citations: 398
Blagden SP, Rizzuto I, Stavraka C, et al., 2015, A first in human Phase I/II study of NUC-1031 in patients with advanced gynecological cancers, Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: American Society of Clinical Oncology, ISSN: 0732-183X
Blagden SP, Rizzuto I, Stavraka C, et al., 2015, Final results of ProGem1, the first in-human phase I/II study of NUC-1031 in patients with solid malignancies, Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: American Society of Clinical Oncology, ISSN: 0732-183X
Ambrosetti MC, De Robertis Lombardi R, Crosara S, et al., 2015, Neoplasms of the ovary, MRI of the Female and Male Pelvis, Pages: 129-158, ISBN: 9783319096582
Adnexal masses (AMs) are common findings among both premenopausal and postmenopausal women. The main goals of an initial diagnostic work-up for an AM are to rule out malignancy and to differentiate between AM requiring surgical intervention and those that can be managed conservatively. Among the gynecological sources, diagnostic entities can be broadly separated into functional or physiological, inflammatory, or neoplastic lesions. The latter category can be split into the following sub-categories: epithelial–stromal tumors, sex cord–stromal tumors, germ cell tumors, and secondary tumors. It is also crucial to consider the clinical context of each individual patient diagnosed with an AM. Multimodality imaging assessment plays a key role in the management of adnexal masses and helps to plan the most appropriate therapeutic approach. The following parameters should be assessed by imaging preoperatively: exact origin of the mass, characterization, likelihood of malignancy, and, when surgery is needed, the feasibility of laparoscopy versus laparotomy Transabdominal and transvaginal ultrasonography (TVUS) represent the first-line imaging technique currently used to evaluate AM. Computed tomography (CT) is commonly performed in preoperative disease assessment of a suspected ovarian malignancy. Magnetic resonance (MR) imaging is now widely accepted as the “problem-solving technique“ for the characterization of an indeterminate AM having both high sensitivity and specificity in discriminating benign versus malignant lesions.
Hameed S, Rockall A, Wills M, 2015, Cross-sectional imaging of neuroendocrine tumours, Neuroendocrine Tumours: Diagnosis and Management, Pages: 97-129, ISBN: 9783662452141
Neuroendocrine tumours consist of heterogeneous and varied group of neoplasms with different clinical expression. Therefore, it is a challenge to diagnose these tumours at an early stage to be able to try to cure the disease or improve clinical performance and quality of life. The most reliable general markers for NETs are still chromogranin A and B, despite the various pitfalls related to analyses of these markers. However, they are still the working horses in most patients with NETs. Neuron-specific enolase (NSE) and pro-GRP are new interesting markers, particularly for patients with poorly differentiated NETs (NEC G3). Both chromogranin A and NSE have demonstrated a potential role as predictors of both response to treatment and survival. New potential circulating markers are microRNAs as well as circulating tumour cells. However, these markers have to be evaluated in larger tumour material to precisely delineate their role. There is still an unmet need for new sensitive markers for early detection and screening for NETs, but the most recent work on whole-genome sequencing might come up with new potential both circulating and tissue markers.
Thomassin-Naggara I, Balvay D, Rockall A, et al., 2015, Added Value of Assessing Adnexal Masses with Advanced MRI Techniques, BIOMED RESEARCH INTERNATIONAL, Vol: 2015, ISSN: 2314-6133
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- Citations: 18
Sundin A, Wills M, Rockall A, 2015, Radiological Imaging: Computed Tomography, Magnetic Resonance Imaging and Ultrasonography, NEUROENDOCRINE TUMORS: A MULTIDISCIPLINARY APPROACH, Vol: 44, Pages: 58-72, ISSN: 0301-3073
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- Citations: 7
Rockall A, 2014, ICIS workshop on adnexal mass characterization, Cancer Imaging, Vol: 14
Tang YZ, Benardin L, Booth TC, et al., 2014, Use of an internal reference in semi-quantitative dynamic contrast-enhanced MRI (DCE MRI) of indeterminate adnexal masses, BRITISH JOURNAL OF RADIOLOGY, Vol: 87, ISSN: 0007-1285
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- Citations: 6
Sudderuddin S, Helbren E, Telesca M, et al., 2014, MRI appearances of benign uterine disease, CLINICAL RADIOLOGY, Vol: 69, Pages: 1095-1104, ISSN: 0009-9260
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- Citations: 26
Tam HH, Arshad M, Bharwani N, et al., 2014, Textural features of primary cervical tumors on FDG PET/CT as a predictor of progression free survival, Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S202-S202, ISSN: 1619-7070
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