Publications
274 results found
Lewis M, Goh V, Beggs S, et al., 2014, Quality control within the multicentre perfusion CT study of primary colorectal cancer (PROSPeCT): results of an iodine density phantom study, EUROPEAN RADIOLOGY, Vol: 24, Pages: 2309-2318, ISSN: 0938-7994
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- Citations: 4
Rockall AG, 2014, Diffusion weighted MRI in ovarian cancer., Curr Opin Oncol, Vol: 26, Pages: 529-535
PURPOSE OF REVIEW: The role of diffusion weighted MRI (DW-MRI) in ovarian cancer management has been the focus of recent research. In this article, the main research interests and the current and future clinical applications of DW-MRI in ovarian cancer will be discussed. RECENT FINDINGS: For characterization of complex adnexal masses, the absence of residual signal intensity on high b-value diffusion weighted images in the solid component of a mass is a strong indicator of benignity, with a high negative predictive value for cancer. Detection of malignant peritoneal implants can be achieved with a high sensitivity and specificity. This is mainly due to the high contrast resolution obtained on DW-MRI images. Changes in the quantifiable parameter of diffusion, the apparent diffusion coefficient (ADC), can be measured to identify response following chemotherapy. Changes in ADC may reflect biological events in the tissue and ultimately may allow the early identification of nonresponders. Differences in ADC or ADC change post-therapy at different tumour sites within the same patient may reflect tumour heterogeneity. SUMMARY: The use of DW-MRI in the characterization of indeterminate adnexal masses is becoming well established and may have an important role in the preoperative confirmation of benignity. DW-MRI in the detection of sites of peritoneal disease and in the early detection of response to chemotherapy remain areas of research interest with great potential.
Kaijser J, Vandecaveye V, Deroose CM, et al., 2014, Imaging techniques for the pre-surgical diagnosis of adnexal tumours, BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, Vol: 28, Pages: 683-695, ISSN: 1521-6934
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- Citations: 32
Rockall AG, Avril N, Lam R, et al., 2014, Repeatability of quantitative FDG-PET/CT and contrast-enhanced CT in recurrent ovarian carcinoma: Test-retest measurements for tumor FDG uptake, diameter, and volume, Clinical Cancer Research, Vol: 20, Pages: 2751-2760, ISSN: 1078-0432
Purpose: Repeatability of baseline FDG-PET/CT measurements has not been tested in ovarian cancer. This dual-center, prospective study assessed variation in tumor 2[18F]fluoro-2-deoxy-D-glucose (FDG) uptake, tumor diameter, and tumor volume from sequential FDG-PET/CT and contrast-enhanced computed tomography (CECT) in patients with recurrent platinum-sensitive ovarian cancer.Experimental Design: Patients underwent two pretreatment baseline FDG-PET/CT (n = 21) and CECT (n = 20) at two clinical sites with different PET/CT instruments. Patients were included if they had at least one target lesion in the abdomen with a standardized uptake value (SUV) maximum (SUVmax) of ≥2.5 and a long axis diameter of ≥15 mm. Two independent reading methods were used to evaluate repeatability of tumor diameter and SUV uptake: on site and at an imaging clinical research organization (CRO). Tumor volume reads were only performed by CRO. In each reading set, target lesions were independently measured on sequential imaging.Results: Median time between FDG-PET/CT was two days (range 1–7). For site reads, concordance correlation coefficients (CCC) for SUVmean, SUVmax, and tumor diameter were 0.95, 0.94, and 0.99, respectively. Repeatability coefficients were 16.3%, 17.3%, and 8.8% for SUVmean, SUVmax, and tumor diameter, respectively. Similar results were observed for CRO reads. Tumor volume CCC was 0.99 with a repeatability coefficient of 28.1%.Conclusions: There was excellent test–retest repeatability for FDG-PET/CT quantitative measurements across two sites and two independent reading methods. Cutoff values for determining change in SUVmean, SUVmax, and tumor volume establish limits to determine metabolic and/or volumetric response to treatment in platinum-sensitive relapsed ovarian cancer.
Bharwani N, Miquel ME, Powles T, et al., 2014, Diffusion-weighted and multiphase contrast-enhanced MRI as surrogate markers of response to neoadjuvant sunitinib in metastatic renal cell carcinoma, BRITISH JOURNAL OF CANCER, Vol: 110, Pages: 616-624, ISSN: 0007-0920
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- Citations: 27
Alfieri J, Narayan K, Rockall A, 2014, What is the role of PET/CT in gynecological cancers?, Controversies in the Management of Gynecological Cancers, Pages: 213-223, ISBN: 9780857299093
Tang YZ, Bharwani N, Micco M, et al., 2014, The prevalence of incidentally detected adrenal enlargement on CT, CLINICAL RADIOLOGY, Vol: 69, Pages: E37-E42, ISSN: 0009-9260
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- Citations: 16
Masselli G, Derchi L, McHugo J, et al., 2013, Acute abdominal and pelvic pain in pregnancy: ESUR recommendations, EUROPEAN RADIOLOGY, Vol: 23, Pages: 3485-3500, ISSN: 0938-7994
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- Citations: 46
Barwick TD, Taylor A, Rockall A, 2013, Functional Imaging to Predict Tumor Response in Locally Advanced Cervical Cancer, CURRENT ONCOLOGY REPORTS, Vol: 15, Pages: 549-558, ISSN: 1523-3790
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- Citations: 36
Soo MJ, Bharwani N, Rockall AG, 2013, Vagina and vulva: Imaging techniques, normal anatomy and anatomical variants, Abdominal Imaging, Pages: 2201-2210, ISBN: 9783642133268
Detecting and evaluating abnormalities of the female vagina and vulva are difficult on imaging due to the limitations inherent in each modality, radiation safety issues, and perhaps cultural restrictions. Computed tomography (CT) does not play a significant role in imaging the vagina and vulva due to poor soft tissue resolution of perineal anatomy. Although ultrasound and magnetic resonance imaging (MRI) often play complimentary roles, MRI is now the predominant imaging modality. It is often superior to both ultrasound and CT because of its ability to produce nondegraded multi-planar images and superior contrast resolution without the use of ionizing radiation. MRI is also noninvasive and allows visualization of the female reproductive organs in their orthotopic positions.
Liyanage S, Bharwani N, Rockall AG, 2013, Malignant conditions of the uterine corpus, Abdominal Imaging, Pages: 2093-2108, ISBN: 9783642133268
Imaging plays an important role in the multidisciplinary management of uterine corpus malignancies. The diagnosis of these tumors is made on histology and staging is surgico-pathological using the Federation of Gynecology and Obstetrics (FIGO) system (Pecorelli 2009). Magnetic resonance imaging (MRI) has emerged as the most widely used imaging technique and is useful in characterization, staging, treatment planning, and subsequent follow-up. MR imaging elegantly demonstrates disease extent and can suggest more aggressive histological subtypes which would necessitate a more radical surgical approach.
Rockall AG, Avril NE, Lam R, et al., 2013, [18F]Fluorodeoxyglucose PET and Volumetric CT analysis are early biomarkers of survival in platinum-sensitive relapsed ovarian cancer - a multicentre trial, European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO, Publisher: ELSEVIER SCI LTD, Pages: S735-S735, ISSN: 0959-8049
Giles JW, Johnson JA, Athwal GS, 2013, Traditional and Modified Latarjet Techniques Letter to the Editor/Response Authors' Response, AMERICAN JOURNAL OF SPORTS MEDICINE, Vol: 41, Pages: NP32-NP32, ISSN: 0363-5465
McNeish I, Anthoney A, Loadman P, et al., 2013, A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of the selective aurora kinase inhibitor GSK1070916A., 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
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- Citations: 7
Allouni AK, Sarkodieh J, Rockall A, 2013, Nodal disease assessment in pelvic malignancy, Imaging, Vol: 22, ISSN: 0965-6812
Accurate identification and characterisation of lymph nodes is essential in staging pelvic malignancies. Confirmation of nodal metastases carries important prognostic and therapeutic significance. Identification of metastatic lymph nodes on imaging can help in treatment planning, disease response and detection of disease recurrence. In this article, the performance of currently available imaging modalities will be discussed. Evolving techniques, such as diffusion-weighted imaging, MR lymphography with nanoparticles, 18-fluorodeoxyglucose positron emission tomography/CT, lymphoscintigraphy and more novel techniques, will also be reviewed. However, no single imaging technique has emerged with high enough diagnostic performance to completely obviate the need for histological confirmation. Nodal size remains the most widely used imaging criterion.
Allouni AK, Sarkodieh J, Rockall A, 2013, Picture quiz: Nodal disease assessment in pelvic malignancy, Imaging, Vol: 22, ISSN: 0965-6812
Thomassin-Naggara I, Aubert E, Rockall A, et al., 2013, Adnexal Masses: Development and Preliminary Validation of an MR Imaging Scoring System, RADIOLOGY, Vol: 267, Pages: 432-443, ISSN: 0033-8419
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- Citations: 136
Sala E, Rockall AG, Freeman SJ, et al., 2013, The Added Role of MR Imaging in Treatment Stratification of Patients with Gynecologic Malignancies: What the Radiologist Needs to Know, RADIOLOGY, Vol: 266, Pages: 717-740, ISSN: 0033-8419
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- Citations: 223
Tang YZ, Liyanage S, Narayanan P, et al., 2013, The MRI features of histologically proven ovarian cystadenofibromas-an assessment of the morphological and enhancement patterns, EUROPEAN RADIOLOGY, Vol: 23, Pages: 48-56, ISSN: 0938-7994
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- Citations: 15
Miquel ME, Scott AD, Macdougall ND, et al., 2012, <i>In vitro</i> and <i>in vivo</i> repeatability of abdominal diffusion-weighted MRI, BRITISH JOURNAL OF RADIOLOGY, Vol: 85, Pages: 1507-1512, ISSN: 0007-1285
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- Citations: 55
Stewart GD, O'Mahony FC, Eory L, et al., 2012, Proteomic analysis of pre- and postsunitinib treated renal cancer tissue to assess tumour heterogeneity and differential protein expression, Publisher: ROYAL SOC MEDICINE PRESS LTD, Pages: 245-246, ISSN: 0036-9330
Mohaghegh P, Rockall AG, 2012, Imaging Strategy for Early Ovarian Cancer: Characterization of Adnexal Masses with Conventional and Advanced Imaging Techniques, RADIOGRAPHICS, Vol: 32, Pages: 1751-1773, ISSN: 0271-5333
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- Citations: 77
Rockall A, Munari A, Avril N, 2012, New ways of assessing ovarian cancer response: metabolic imaging and beyond, CANCER IMAGING, Vol: 12, Pages: 310-314, ISSN: 1740-5025
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- Citations: 12
Willmott F, Allouni KA, Rockall A, 2012, Radiological manifestations of metastasis to the ovary, JOURNAL OF CLINICAL PATHOLOGY, Vol: 65, Pages: 585-590, ISSN: 0021-9746
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- Citations: 19
Roche O, Chavan N, Aquilina J, et al., 2012, Radiological appearances of gynaecological emergencies., Insights Imaging, Vol: 3, Pages: 265-275
BACKGROUND: The role of various gynaecological imaging modalities is vital in aiding clinicians to diagnose acute gynaecological disease, and can help to direct medical and surgical treatment where appropriate. It is important to interpret the imaging findings in the context of the clinical signs and patient's pregnancy status. METHODS: Ultrasound and Doppler are readily available in the emergency department, and demonstrate features of haemorrhagic follicular cysts, ovarian cyst rupture, endometriotic cysts and pyosalpinx. Adnexal torsion may also be identified using ultrasound and Doppler, although the diagnosis cannot be safely excluded based on imaging alone. Computed tomography (CT) is not routinely employed in diagnosing acute gynaecological complications. However due to similar symptoms and signs with gastrointestinal and urinary tract pathologies, it is frequently used as the initial imaging modality and recognition of features of gynaecological complications on CT is important. RESULTS: Although MRI is not frequently used in the emergency setting, it is an important modality in characterising features that are unclear on ultrasound and CT. CONCLUSION: MRI is particularly helpful in identifying the site of origin of large pelvic masses, such as haemorrhagic uterine fibroid degeneration and fibroid prolapse or torsion. In this article, we review the imaging appearances of gynaecological emergencies in non-pregnant patients. TEACHING POINTS: • Ultrasonography is easily accessible and can identify life-threatening gynaecological complications. • Tomography scanners and computed radiography are not routinely used but are important to recognise key features. • MRI is used for the characterisation of acute gynaecological complications. • Recognition of the overlap in symptoms between gastrointestinal and gynaecological conditions is essential.
Bharwani N, Newland A, Tunariu N, et al., 2012, Re: Can MRI predict the diagnosis of endometrial carcinosarcoma?, CLINICAL RADIOLOGY, Vol: 67, Pages: 396-396, ISSN: 0009-9260
Bernardin L, Dilks P, Liyanage S, et al., 2012, Effectiveness of semi-quantitative multiphase dynamic contrast-enhanced MRI as a predictor of malignancy in complex adnexal masses: radiological and pathological correlation, EUROPEAN RADIOLOGY, Vol: 22, Pages: 880-890, ISSN: 0938-7994
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- Citations: 57
Rockall AG, Cross S, Flanagan S, et al., 2012, The role of FDG-PET/CT in gynaecological cancers, CANCER IMAGING, Vol: 12, Pages: 49-65, ISSN: 1470-7330
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- Citations: 32
Boleti E, Sarwar N, Jones RR, et al., 2012, The safety and efficacy of pazopanib prior to planned nephrectomy in metastatic clear cell renal cancer., Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
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- Citations: 1
Stewart GD, O'Mahony F, Eory L, et al., 2012, Proteomic analysis of pre- and post-sunitinib treated renal cancer tissue to assess tumor heterogeneity and differential protein expression., Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
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