Imperial College London
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ProfessorAndreaRockall

Faculty of Medicine, Department of Surgery & Cancer

Clinical Chair in Radiology
 
 
 
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a.rockall

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lavdas:2018:10.1016/j.crad.2018.04.011,
author = {Lavdas, I and Rockall, AG and Daulton, E and Kozlowski, K and Honeyfield, L and Aboagye, EO and Sharma, R},
doi = {10.1016/j.crad.2018.04.011},
journal = {Clinical Radiology},
pages = {832.e9--832.e16},
title = {Histogram analysis of apparent diffusion coefficient from whole-body diffusion-weighted MRI to predict early response to chemotherapy in patients with metastatic colorectal cancer: preliminary results},
url = {http://dx.doi.org/10.1016/j.crad.2018.04.011},
volume = {73},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AimTo evaluate apparent diffusion coefficient (ADC) histogram analysis parameters, acquired from whole-body diffusion-weighted magnetic resonance imaging (DW-MRI), as very early predictors of response to chemotherapy in patients with metastatic colorectal cancer (mCRC).Materials and methodsThis was a single-institution prospective study, approved by the West Midlands-South Birmingham research ethics committee. All patients gave fully informed consent prior to imaging. Sixteen patients with histologically confirmed mCRC were enrolled to the study and 11 were successfully scanned with whole-body DW-MRI before (baseline) and 10.8±2.7 days after commencing chemotherapy (follow-up). Therapy response was assessed by RECIST 1.1. Mean ADC and histogram parameters (skewness, kurtosis, 25th, 50th, and 75th percentiles) were compared between progressors and non-progressors at baseline and follow-up. Receiver operating characteristics (ROC) analysis was performed for the statistically significant parameters. Data from metastases were also compared to normative tissue data acquired from healthy volunteers.ResultsThree patients had progressive disease (progressors) and eight had partial response/stable disease (non-progressors). Mean, 25th, 50th, and 75th percentiles were significantly lower for progressors at baseline (p=0.012, 0.012, 0.012 and 0.025 respectively) with areas under the ROC curves (AUC)=0.58, 0.50, 0.58 and 0.63, respectively. Skewness and kurtosis were significantly lower for non-progressors at follow-up (p=0.001 and 0.003 respectively) with AUC=0.67 and 0.79 respectively.ConclusionADC histogram analysis shows potential in discriminating progressive from non-progressive disease in patients with mCRC, who underwent whole-body DW-MRI. The technique can potentially be tested as a response assessment methodology in larger trials.
AU  - Lavdas,I
AU  - Rockall,AG
AU  - Daulton,E
AU  - Kozlowski,K
AU  - Honeyfield,L
AU  - Aboagye,EO
AU  - Sharma,R
DO  - 10.1016/j.crad.2018.04.011
EP  - 9
PY  - 2018///
SN  - 0009-9260
SP  - 832
TI  - Histogram analysis of apparent diffusion coefficient from whole-body diffusion-weighted MRI to predict early response to chemotherapy in patients with metastatic colorectal cancer: preliminary results
T2  - Clinical Radiology
UR  - http://dx.doi.org/10.1016/j.crad.2018.04.011
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000440578500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0009926018301703?via%3Dihub
UR  - http://hdl.handle.net/10044/1/82262
VL  - 73
ER  -
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