Imperial College London
Portrait Picture

ProfessorAndreaRockall

Faculty of Medicine, Department of Surgery & Cancer

Clinical Chair in Radiology
 
 
 
//

Contact

 

a.rockall

 
 
//

Location

 

ICTEM buildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Thomassin-Naggara:2020:10.1001/jamanetworkopen.2019.19896,
author = {Thomassin-Naggara, I and Poncelet, E and Jalaguier-Coudray, A and Guerra, A and Fournier, LS and Stojanovic, S and Millet, I and Bharwani, N and Juhan, V and Cunha, TM and Masselli, G and Balleyguier, C and Malhaire, C and Perrot, NF and Sadowski, EA and Bazot, M and Taourel, P and Porcher, R and Darai, E and Reinhold, C and Rockall, AG},
doi = {10.1001/jamanetworkopen.2019.19896},
journal = {JAMA Network Open},
pages = {1--14},
title = {Ovarian-Adnexal Reporting Data System Magnetic Resonance Imaging (O-RADS MRI) score for risk stratification of sonographically indeterminate adnexal masses.},
url = {http://dx.doi.org/10.1001/jamanetworkopen.2019.19896},
volume = {3},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance: Approximately one-quarter of adnexal masses detected at ultrasonography are indeterminate for benignity or malignancy, posing a substantial clinical dilemma. Objective: To validate the accuracy of a 5-point Ovarian-Adnexal Reporting Data System Magnetic Resonance Imaging (O-RADS MRI) score for risk stratification of adnexal masses. Design, Setting, and Participants: This multicenter cohort study was conducted between March 1, 2013, and March 31, 2016. Among patients undergoing expectant management, 2-year follow-up data were completed by March 31, 2018. A routine pelvic MRI was performed among consecutive patients referred to characterize a sonographically indeterminate adnexal mass according to routine diagnostic practice at 15 referral centers. The MRI score was prospectively applied by 2 onsite readers and by 1 reader masked to clinical and ultrasonographic data. Data analysis was conducted between April and November 2018. Main Outcomes and Measures: The primary end point was the joint analysis of true-negative and false-negative rates according to the MRI score compared with the reference standard (ie, histology or 2-year follow-up). Results: A total of 1340 women (mean [range] age, 49 [18-96] years) were enrolled. Of 1194 evaluable women, 1130 (94.6%) had a pelvic mass on MRI with a reference standard (surgery, 768 [67.9%]; 2-year follow-up, 362 [32.1%]). A total of 203 patients (18.0%) had at least 1 malignant adnexal or nonadnexal pelvic mass. No invasive cancer was assigned a score of 2. Positive likelihood ratios were 0.01 for score 2, 0.27 for score 3, 4.42 for score 4, and 38.81 for score 5. Area under the receiver operating characteristic curve was 0.961 (95% CI, 0.948-0.971) among experienced readers, with a sensitivity of 0.93 (95% CI, 0.89-0.96; 189 of 203 patients) and a specificity of 0.91 (95% CI, 0.89-0.93; 848 of 927 patients). There was good interrater agreement among both experienced and junior readers (κ = 0.784
AU  - Thomassin-Naggara,I
AU  - Poncelet,E
AU  - Jalaguier-Coudray,A
AU  - Guerra,A
AU  - Fournier,LS
AU  - Stojanovic,S
AU  - Millet,I
AU  - Bharwani,N
AU  - Juhan,V
AU  - Cunha,TM
AU  - Masselli,G
AU  - Balleyguier,C
AU  - Malhaire,C
AU  - Perrot,NF
AU  - Sadowski,EA
AU  - Bazot,M
AU  - Taourel,P
AU  - Porcher,R
AU  - Darai,E
AU  - Reinhold,C
AU  - Rockall,AG
DO  - 10.1001/jamanetworkopen.2019.19896
EP  - 14
PY  - 2020///
SN  - 2574-3805
SP  - 1
TI  - Ovarian-Adnexal Reporting Data System Magnetic Resonance Imaging (O-RADS MRI) score for risk stratification of sonographically indeterminate adnexal masses.
T2  - JAMA Network Open
UR  - http://dx.doi.org/10.1001/jamanetworkopen.2019.19896
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31977064
UR  - https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2759282
UR  - http://hdl.handle.net/10044/1/76709
VL  - 3
ER  -
Download