Imperial College London
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ProfessorAndreaRockall

Faculty of Medicine, Department of Surgery & Cancer

Clinical Chair in Radiology
 
 
 
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Contact

 

a.rockall

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arshad:2020:10.1007/s00259-020-05136-8,
author = {Arshad, MA and Gitau, S and Tam, H and Park, W-HE and Patel, NH and Rockall, A and Aboagye, EO and Bharwani, N and Barwick, TD},
doi = {10.1007/s00259-020-05136-8},
journal = {European Journal of Nuclear Medicine and Molecular Imaging},
pages = {1--15},
title = {Optimal method for metabolic tumour volume assessment of cervical cancers with inter-observer agreement on [18F]-fluoro-deoxy-glucose positron emission tomography with computed tomography},
url = {http://dx.doi.org/10.1007/s00259-020-05136-8},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeCervical cancer metabolic tumour volume (MTV) derived from [18F]-FDG PET/CT has a role in prognostication and therapy planning. There is no standard method of outlining MTV on [18F]-FDG PET/CT. The aim of this study was to assess the optimal method to outline primary cervical tumours on [18F]-FDG PET/CT using MRI-derived tumour volumes as the reference standard.Methods81 consecutive cervical cancer patients with pre-treatment staging MRI and [18F]-FDG PET/CT imaging were included. MRI volumes were compared with different PET segmentation methods. Method 1 measured MTVs at different SUVmax thresholds ranging from 20 to 60% (MTV20-MTV60) with bladder masking and manual adjustment when required. Method 2 created an isocontour around the tumour prior to different SUVmax thresholds being applied. Method 3 used an automated gradient method. Inter-observer agreement of MTV, following manual adjustment when required, was recorded.ResultsFor method 1, the MTV25 and MTV30 were closest to the MRI volumes for both readers (mean percentage change from MRI volume of 2.9% and 13.4% for MTV25 and − 13.1% and − 2.0% for MTV30 for readers 1 and 2). 70% of lesions required manual adjustment at MTV25 compared with 45% at MTV30. There was excellent inter-observer agreement between MTV30 to MTV60 (ICC ranged from 0.898–0.976 with narrow 95% confidence intervals (CIs)) and moderate agreement at lower thresholds (ICC estimates of 0.534 and 0.617, respectively for the MTV20 and MTV25 with wide 95% CIs). Bladder masking was performed in 86% of cases overall. For method 2, excellent correlation was demonstrated at MTV25 and MTV30 (mean % change from MRI volume of −3.9% and − 8.6% for MTV25 and − 16.9% and 19% for MTV30 for readers 1 and 2, respectively). This method also demonstrated excellent ICC across all thresholds with no manual adjustment. Method 3 demonstrated excellent ICC of 0.96 (95% CI 0.94–0.97) but had a
AU  - Arshad,MA
AU  - Gitau,S
AU  - Tam,H
AU  - Park,W-HE
AU  - Patel,NH
AU  - Rockall,A
AU  - Aboagye,EO
AU  - Bharwani,N
AU  - Barwick,TD
DO  - 10.1007/s00259-020-05136-8
EP  - 15
PY  - 2020///
SN  - 0340-6997
SP  - 1
TI  - Optimal method for metabolic tumour volume assessment of cervical cancers with inter-observer agreement on [18F]-fluoro-deoxy-glucose positron emission tomography with computed tomography
T2  - European Journal of Nuclear Medicine and Molecular Imaging
UR  - http://dx.doi.org/10.1007/s00259-020-05136-8
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000597772900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs00259-020-05136-8
UR  - http://hdl.handle.net/10044/1/86285
ER  -
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