Imperial College London

DrAileenRowan

Faculty of MedicineDepartment of Infectious Disease

Lecturer in Molecular Virology
 
 
 
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Contact

 

+44 (0)20 7594 3916a.rowan

 
 
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Location

 

VD4Wright Fleming WingSt Mary's Campus

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Summary

 

Summary

My research focuses on how the Human T cell leukaemia virus type-1 (HTLV-1) causes blood cancer (Adult T cell leukaemia lymphoma, ATL) in ~5% of people who are chronically infected with the virus.    

I work in close collaboration with the National Centre for Human Retrovirology and its associated UKAS-accredited Molecular Diagnostic Unit, which develops and provides specialised diagnostics for HTLV-1 carriers.

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Selected Publications

Journal Articles

Rowan A, Joris T, Haddow J, et al., 2023, Detection of HTLV-1 proviral DNA in cell-free DNA: potential for non-invasive monitoring of Adult T cell leukaemia/lymphoma using liquid biopsy?, Frontiers in Immunology, Vol:14, ISSN:1664-3224, Pages:1-7

Rowan A, Ponnusamy K, Ren H, et al., 2023, CAR-iNKT cells targeting clonal TCRVβ chains as a precise strategy to treat T cell lymphoma, Frontiers in Immunology, Vol:14, ISSN:1664-3224, Pages:1-11

Cordery R, Reeves L, Zhou J, et al., 2022, Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in London, The Lancet Microbe, Vol:3, ISSN:2666-5247, Pages:e814-e823

Katsuya H, Cook LBM, Rowan AG, et al., 2022, Clonality of HIV-1- and HTLV-1-Infected Cells in Naturally Coinfected Individuals (vol 225, pg 317, 2021), Journal of Infectious Diseases, Vol:225, ISSN:0022-1899, Pages:359-359

Katsuya H, Cook LBM, Rowan AG, et al., 2022, Clonality of HIV-1 and HTLV-1 infected cells in naturally coinfected individuals, Journal of Infectious Diseases, Vol:225, ISSN:0022-1899, Pages:317-326

Cook L, Rowan A, Bangham C, 2021, Adult T-cell leukemia/lymphoma—pathobiology and implications for modern clinical management, Annals of Lymphoma, Vol:5, ISSN:2616-2695, Pages:1-10

Rowan AG, May P, Badhan A, et al., 2021, Optimized protocol for a quantitative SARS-CoV-2 duplex RT-qPCR assay with internal human sample sufficiency control., Journal of Virological Methods, Vol:294, ISSN:0166-0934, Pages:1-7

Rosadas de Oliveira C, Woo T, Haddow J, et al., 2021, Anti-HTLV-1/2 IgG antibodies in the breastmilk of seropositive mothers, Microorganisms, Vol:9, ISSN:2076-2607, Pages:1-8

Wolf S, Haddow J, Greiller C, et al., 2021, Quantification of T cell clonality in Human T cell leukaemia virus type-1 carriers can detect the development of Adult T cell Leukaemia early, Blood Cancer Journal, Vol:11, ISSN:2044-5385, Pages:1-11

Gibani MM, Toumazou C, Sohbati M, et al., 2020, Assessing a novel, lab-free, point-of-care test for SARS-CoV-2 (CovidNudge): a diagnostic accuracy study., The Lancet Microbe, Vol:1, ISSN:2666-5247, Pages:e300-e307

Rowan AG, Dillon R, Witkover A, et al., 2020, Evolution of retrovirus-infected premalignant T-cell clones prior to Adult T-cell leukemia/lymphoma diagnosis, Blood, Vol:135, ISSN:0006-4971, Pages:2023-2032

Cook LBM, Rowan AG, 2020, CD28 fusions: an opportunity for young ATL?, Blood, Vol:135, ISSN:0006-4971, Pages:1415-1416

Saeed Z, Rowan A, Greiller C, et al., 2020, Enhanced T-cell maturation and monocyte aggregation are features of cellular inflammation in human T-lymphotropic virus type-1-associated myelopathy, Clinical Infectious Diseases, Vol:70, ISSN:1058-4838, Pages:1326-1335

Cook LBM, Demontis MA, Sagawe S, et al., 2019, Molecular remissions are observed in chronic adult T-cell leukemia/lymphoma in patients treated with mogamulizumab, Haematologica - the Hematology Journal, Vol:104, ISSN:0390-6078, Pages:e566-e569

Katsuya H, Cook LB, Rowan A, et al., 2018, Phosphatidylinositol 3-kinase-delta (PI3K-delta) is a potential therapeutic target in adult T-cell leukemia-lymphoma, Biomarker Research, Vol:6, ISSN:2050-7771

Cook LB, Rowan A, Demontis M, et al., 2017, Long-term clinical remission maintained after cessation of zidovudine and interferon-α therapy in chronic adult T-cell leukemia/lymphoma, International Journal of Hematology, Vol:107, ISSN:0925-5710, Pages:378-382

Rowan AG, Witkover A, Melamed A, et al., 2016, T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells., Plos Pathog, Vol:12

Manivannan K, Rowan AG, Tanaka Y, et al., 2016, CADM1/TSLC1 Identifies HTLV-1-Infected Cells and Determines Their Susceptibility to CTL-Mediated Lysis., Plos Pathog, Vol:12

Satou Y, Miyazato P, Ishihara Y, et al., 2016, The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome, Proceedings of the National Academy of Sciences of the United States of America, Vol:113, ISSN:0027-8424, Pages:3054-3059

Bangham CRM, Melamed A, Laydon D, et al., 2015, HTLV-1 drives vigorous clonal expansion of infected CD8 + T cells in natural infection, Retrovirology, Vol:12, ISSN:1742-4690

Rowan AG, Suemori K, Fujiwara H, et al., 2014, Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression, Retrovirology, Vol:11, ISSN:1742-4690

Rowan AG, Suemori K, Fujiwara H, et al., 2014, Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression, Retrovirology, Vol:11

Melamed A, Witkover AD, Laydon DJ, et al., 2014, Clonality of HTLV-2 in natural infection, PLOS Pathogens, Vol:10, ISSN:1553-7366, Pages:1-9

Cook LB, Elemans M, Rowan AG, et al., 2013, HTLV-1: Persistence and pathogenesis, Virology, Vol:435, ISSN:0042-6822, Pages:131-140

Cook LB, Rowan AG, Melamed A, et al., 2012, HTLV-1-infected T cells contain a single integrated provirus in natural infection, Blood, Vol:120, ISSN:0006-4971, Pages:3488-3490

Rowan AG, Bangham CRM, 2011, Is there a role for HTLV-1-specific CTL in adult T-cell Leukemia/Lymphoma?, Leukemia Research and Treatment, Vol:2012, ISSN:2090-3219

Kress AK, Kalmer M, Rowan AG, et al., 2011, The tumor marker Fascin is strongly induced by the Tax oncoprotein of HTLV-1 through NF-κB signals, Blood, Vol:117, ISSN:0006-4971, Pages:3609-3612

Hilburn S, Rowan A, Demontis M-A, et al., 2011, In vivo Expression of Human T-lymphotropic Virus Type 1 Basic Leucine-Zipper Protein Generates Specific CD8+and CD4+T-Lymphocyte Responses that Correlate with Clinical Outcome, Journal of Infectious Diseases, Vol:203, ISSN:0022-1899, Pages:529-536

MacNamara A, Rowan A, Hilburn S, et al., 2010, HLA Class I Binding of HBZ Determines Outcome in HTLV-1 Infection, PLOS Pathogens, Vol:6, ISSN:1553-7366

Kattan T, MacNamara A, Rowan AG, et al., 2009, The Avidity and Lytic Efficiency of the CTL Response to HTLV-1, Journal of Immunology, Vol:182, ISSN:0022-1767, Pages:5723-5729

Rowan AG, Fletcher JM, Ryan EJ, et al., 2008, Hepatitis C virus-specific th17 cells are suppressed by virus-induced TGF-β, Journal of Immunology, Vol:181, ISSN:0022-1767, Pages:4485-4494

Brady MT, MacDonald AJ, Rowan AG, et al., 2003, Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes, European Journal of Immunology, Vol:33, ISSN:0014-2980, Pages:3448-3457

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