DrAileenRowan

Faculty of Medicine, Department of Infectious Disease

Lecturer in Molecular Virology

Contact

+44 (0)20 7594 3908a.rowan

Location

VD4Wright Fleming WingSt Mary's Campus

Summary

My research focuses on how the Human T cell leukaemia virus type-1 (HTLV-1) causes blood cancer (Adult T cell leukaemia lymphoma, ATL) in ~5% of people who are chronically infected with the virus.

I work in close collaboration with the National Centre for Human Retrovirology and its associated UKAS-accredited Molecular Diagnostic Unit, which develops and provides specialised diagnostics for HTLV-1 carriers.

I am currently split between the Department of Infectious Disease and the Centre for Haematology in the Department of Immunity and Inflammation, where I am developing a novel cell therapy approach for ATL.

Selected Publications

Journal Articles

Rowan AG, May P, Badhan A, et al.Rowan AG, May P, Badhan A, Herrera C, Watber P, Penn R, Crone MA, Storch M, Garson JA, McClure M, Freemont PS, Madona P, Randell P, Taylor GP close, 2021, Optimized protocol for a quantitative SARS-CoV-2 duplex RT-qPCR assay with internal human sample sufficiency control., Journal of Virological Methods, Vol:294, ISSN:0166-0934, Pages:1-7

Wolf S, Haddow J, Greiller C, et al.Wolf S, Haddow J, Greiller C, Taylor G, Cook L, Rowan A close, 2021, Quantification of T cell clonality in Human T cell leukaemia virus type-1 carriers can detect the development of Adult T cell Leukaemia early, Blood Cancer Journal, Vol:11, ISSN:2044-5385, Pages:1-11

Rowan AG, Dillon R, Witkover A, et al.Rowan AG, Dillon R, Witkover A, Melamed A, Demontis M-A, Gillet NA, Mun LJ, Bangham CRM, Cook LB, Fields PA, Taylor GP close, 2020, Evolution of retrovirus-infected premalignant T-cell clones prior to Adult T-cell leukemia/lymphoma diagnosis, Blood, Vol:135, ISSN:0006-4971, Pages:2023-2032

Cook LBM, Demontis MA, Sagawe S, et al.Cook LBM, Demontis MA, Sagawe S, Witkover A, Melamed A, Turpin J, Dillon R, Haddow J, Marks AJ, Bangham CRM, Fields P, Taylor GP, Rowan AG close, 2019, Molecular remissions are observed in chronic adult T-cell leukemia/lymphoma in patients treated with mogamulizumab, Haematologica - the Hematology Journal, Vol:104, ISSN:0390-6078, Pages:e566-e569

Cook LB, Rowan A, Demontis M, et al.Cook LB, Rowan A, Demontis M, Sagawe S, Gillet N, Melamed A, Greiller C, Witkover A, Bangham C, Taylor GP close, 2017, Long-term clinical remission maintained after cessation of zidovudine and interferon-α therapy in chronic adult T-cell leukemia/lymphoma, International Journal of Hematology, Vol:107, ISSN:0925-5710, Pages:378-382

Rowan AG, Witkover A, Melamed A, et al.Rowan AG, Witkover A, Melamed A, Tanaka Y, Cook LBM, Fields P, Taylor GP, Bangham CRM close, 2016, T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells., Plos Pathog, Vol:12

Manivannan K, Rowan AG, Tanaka Y, et al.Manivannan K, Rowan AG, Tanaka Y, Taylor GP, Bangham CRM close, 2016, CADM1/TSLC1 Identifies HTLV-1-Infected Cells and Determines Their Susceptibility to CTL-Mediated Lysis., Plos Pathog, Vol:12

Rowan AG, Suemori K, Fujiwara H, et al.Rowan AG, Suemori K, Fujiwara H, Yasukawa M, Tanaka Y, Taylor GP, Bangham CRM close, 2014, Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression, Retrovirology, Vol:11, ISSN:1742-4690

Cook LB, Rowan AG, Melamed A, et al.Cook LB, Rowan AG, Melamed A, Taylor GP, Bangham CRM close, 2012, HTLV-1-infected T cells contain a single integrated provirus in natural infection, Blood, Vol:120, ISSN:0006-4971, Pages:3488-3490

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