My research focuses on how the Human T cell leukaemia virus type-1 (HTLV-1) causes blood cancer (Adult T cell leukaemia lymphoma, ATL) in ~5% of people who are chronically infected with the virus.
I work in close collaboration with the National Centre for Human Retrovirology and its associated UKAS-accredited Molecular Diagnostic Unit, which develops and provides specialised diagnostics for HTLV-1 carriers.
I am currently split between the Department of Infectious Disease and the Centre for Haematology in the Department of Immunity and Inflammation, where I am developing a novel cell therapy approach for ATL.
et al., 2021, Optimized protocol for a quantitative SARS-CoV-2 duplex RT-qPCR assay with internal human sample sufficiency control., Journal of Virological Methods, Vol:294, ISSN:0166-0934, Pages:1-7
et al., 2021, Quantification of T cell clonality in Human T cell leukaemia virus type-1 carriers can detect the development of Adult T cell Leukaemia early, Blood Cancer Journal, Vol:11, ISSN:2044-5385, Pages:1-11
et al., 2020, Evolution of retrovirus-infected premalignant T-cell clones prior to Adult T-cell leukemia/lymphoma diagnosis, Blood, Vol:135, ISSN:0006-4971, Pages:2023-2032
et al., 2019, Molecular remissions are observed in chronic adult T-cell leukemia/lymphoma in patients treated with mogamulizumab, Haematologica - the Hematology Journal, Vol:104, ISSN:0390-6078, Pages:e566-e569
et al., 2017, Long-term clinical remission maintained after cessation of zidovudine and interferon-α therapy in chronic adult T-cell leukemia/lymphoma, International Journal of Hematology, Vol:107, ISSN:0925-5710, Pages:378-382
et al., 2016, T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells., Plos Pathog, Vol:12
et al., 2016, CADM1/TSLC1 Identifies HTLV-1-Infected Cells and Determines Their Susceptibility to CTL-Mediated Lysis., Plos Pathog, Vol:12
et al., 2014, Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression, Retrovirology, Vol:11, ISSN:1742-4690
et al., 2012, HTLV-1-infected T cells contain a single integrated provirus in natural infection, Blood, Vol:120, ISSN:0006-4971, Pages:3488-3490