Imperial College London
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DrAileenRowan

Faculty of Medicine, Department of Infectious Disease

Lecturer in Molecular Virology
 
 
 
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Contact

 

+44 (0)20 7594 3916a.rowan

 
 
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Location

 

VD4Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rowan:2020:10.1182/blood.2019002665,
author = {Rowan, AG and Dillon, R and Witkover, A and Melamed, A and Demontis, M-A and Gillet, NA and Mun, LJ and Bangham, CRM and Cook, LB and Fields, PA and Taylor, GP},
doi = {10.1182/blood.2019002665},
journal = {Blood},
pages = {2023--2032},
title = {Evolution of retrovirus-infected premalignant T-cell clones prior to Adult T-cell leukemia/lymphoma diagnosis},
url = {http://dx.doi.org/10.1182/blood.2019002665},
volume = {135},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Adult T cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy caused by Human T-cell leukemia virus type-1 (HTLV-1). ATL is preceded by decades of chronic HTLV-1 infection, and the tumors carry both somatic mutations and proviral DNA integrated into the tumor genome. In order to gain insight into the oncogenic process, we used targeted sequencing to track the evolution of the malignant clone in six individuals, 2-10 years before the diagnosis of ATL. Clones of premalignant HTLV-1-infected cells bearing known driver mutations were detected in the blood up to 10 years before individuals developed acute and lymphoma subtype ATL. Six months before diagnosis, the total number and variant allele fraction of mutations increased in the blood. Peripheral blood mononuclear cells from premalignant cases (1 year pre-diagnosis) had significantly higher mutational burden in genes frequently mutated in ATL than did high risk, age-matched HTLV-1-carriers who remained ATL-free after a median of 10 years of follow up. These data show that HTLV-1-infected T cell clones carrying key oncogenic driver mutations can be detected in cases of ATL years before the onset of symptoms. Early detection of such mutations may enable earlier and more effective intervention to prevent the development of ATL.
AU  - Rowan,AG
AU  - Dillon,R
AU  - Witkover,A
AU  - Melamed,A
AU  - Demontis,M-A
AU  - Gillet,NA
AU  - Mun,LJ
AU  - Bangham,CRM
AU  - Cook,LB
AU  - Fields,PA
AU  - Taylor,GP
DO  - 10.1182/blood.2019002665
EP  - 2032
PY  - 2020///
SN  - 0006-4971
SP  - 2023
TI  - Evolution of retrovirus-infected premalignant T-cell clones prior to Adult T-cell leukemia/lymphoma diagnosis
T2  - Blood
UR  - http://dx.doi.org/10.1182/blood.2019002665
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32160278
UR  - https://ashpublications.org/blood/article/135/23/2023/452636/Evolution-of-retrovirus-infected-premalignant-T
UR  - http://hdl.handle.net/10044/1/78058
VL  - 135
ER  -
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