Imperial College London
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DrAileenRowan

Faculty of Medicine, Department of Infectious Disease

Lecturer in Molecular Virology
 
 
 
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Contact

 

+44 (0)20 7594 3916a.rowan

 
 
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Location

 

VD4Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rosadas:2021:10.3390/microorganisms9071413,
author = {Rosadas, de Oliveira C and Woo, T and Haddow, J and Rowan, A and Taylor, G},
doi = {10.3390/microorganisms9071413},
journal = {Microorganisms},
pages = {1--8},
title = {Anti-HTLV-1/2 IgG antibodies in the breastmilk of seropositive mothers},
url = {http://dx.doi.org/10.3390/microorganisms9071413},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: HTLV-1/2 mother-to-child transmission (MTCT) is an important route for the maintenance of HTLV-1/2 within populations and disproportionally contributes to the burden of HTLV-1-associated diseases. Avoidance of breastfeeding is the safest recommendation to prevent MTCT. Due to the benefits of breastfeeding, alternative methods that would allow seropositive mothers to breastfeed their babies are needed. There is limited knowledge about HTLV-1/2 infection and breastmilk. Methods: Paired blood and milk samples collected from HTLV-1/2 seropositive mothers were tested for HTLV-1 proviral load (PVL) quantification and for the detection of anti-HTLV-1/2 IgG. Results: All breastmilk samples had detectable anti-HTLV-1/2 IgG. HTLV-1/2 proviral DNA was detected in all samples except for one. HTLV-1 PVL and IgG binding ratio (BR) was similar in milk and plasma. However, antibody titer was significantly higher in blood (Median (95%CI): Milk:128 (32–512); Plasma:131,584 (16,000–131,584), p < 0.05). There was a strong correlation between HTLV-1 PVL, anti-HTLV-1/2 IgG BR, and titer when comparing milk and blood. PVL did not correlate with antibody BR nor titer in blood or milk. Conclusions: Anti-HTLV-1/2 IgG are present in milk in the same proportion as blood but in lower quantity. PVL in milk correlates with blood.
AU  - Rosadas,de Oliveira C
AU  - Woo,T
AU  - Haddow,J
AU  - Rowan,A
AU  - Taylor,G
DO  - 10.3390/microorganisms9071413
EP  - 8
PY  - 2021///
SN  - 2076-2607
SP  - 1
TI  - Anti-HTLV-1/2 IgG antibodies in the breastmilk of seropositive mothers
T2  - Microorganisms
UR  - http://dx.doi.org/10.3390/microorganisms9071413
UR  - https://www.mdpi.com/2076-2607/9/7/1413
UR  - http://hdl.handle.net/10044/1/90669
VL  - 9
ER  -
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