Imperial College London
Alternate

Professor Amir H Sam

Faculty of Medicine, Faculty of Medicine Centre

Head of Imperial College School of Medicine, Professor
 
 
 
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Contact

 

a.sam

 
 
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Location

 

148Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bhatt:2019:10.1007/s42000-019-00114-8,
author = {Bhatt, PS and Sam, AH and Meeran, KM and Salem, V},
doi = {10.1007/s42000-019-00114-8},
journal = {Hormones (Athens, Greece)},
pages = {307--313},
title = {The relevance of cortisol co-secretion from aldosterone-producing adenomas},
url = {http://dx.doi.org/10.1007/s42000-019-00114-8},
volume = {18},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIMS AND OBJECTIVES: Adrenal adenomas are usually non-functioning, but can secrete aldosterone or cortisol. It has recently been suggested that many more adenomas than previously thought secrete more than one hormone. This has important implications for their clinical management. Our aim was to determine the frequency of cortisol co-secretion in primary hyperaldosteronism at our institution and investigate the difference in metabolic profiles and clinical outcomes between co-secreting and non-co-secreting patients. DESIGN AND PATIENTS: A retrospective study of 25 patients with primary hyperaldosteronism who also underwent formal dexamethasone suppression tests to determine cortisol co-secretion. MEASUREMENTS: Post-dexamethasone suppression test cortisol, serum ALT, total cholesterol, HDL-cholesterol, LDL-cholesterol, HbA1C (were recorded) and mean arterial pressure are reported in this cohort of patients with primary hyperaldosteronism. RESULTS: Four out of 25 patients with primary hyperaldosteronism failed dexamethasone suppression tests. This suggests a frequency of co-secretion ranging between 4 and 16%. No significant difference was found in serum ALT, total cholesterol, serum HDL-cholesterol, LDL-cholesterol and mean arterial blood pressure at presentation between co-secretors and non-co-secretors. CONCLUSION: A frequency range of 4-16% suggests that a significant proportion of patients with primary hyperaldosteronism co-secrete cortisol. Co-secretors did not have a worse metabolic profile than non-secretors. The impact of co-secretion on metabolic profile and surgical management remains unclear and warrants further study.
AU  - Bhatt,PS
AU  - Sam,AH
AU  - Meeran,KM
AU  - Salem,V
DO  - 10.1007/s42000-019-00114-8
EP  - 313
PY  - 2019///
SN  - 1109-3099
SP  - 307
TI  - The relevance of cortisol co-secretion from aldosterone-producing adenomas
T2  - Hormones (Athens, Greece)
UR  - http://dx.doi.org/10.1007/s42000-019-00114-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31399957
UR  - http://hdl.handle.net/10044/1/75057
VL  - 18
ER  -
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