Imperial College London

Dr Amanda Sathyapala

Faculty of MedicineNational Heart & Lung Institute

Clinical Senior Lecturer



+44 (0)20 7594 7988a.sathyapala




B143Guy Scadding BuildingRoyal Brompton Campus






Amanda Sathyapala is a Senior Lecturer in the Airways Disease Section of the National Heart and Lung Institute of Imperial College London and a Consultant Respiratory Physician, and Clinical Lead of the Home Ventilation Service, at Harefield Hospital.  Her interests and expertise are in skeletal muscle dysfunction and changes in fibre type and reduction in oxidative mitochondrial metabolism in the skeletal muscle of patients with COPD, as well as sleep-disordered breathing, chronic respiratory failure and home nocturnal ventilation.



Dr Sathyapala studied Medicine at Cambridge University (1993–96) and Oxford University (1996–99), obtaining First Class Honours both in Medicine and also in Experimental Psychology during an intercalated BSc year. Dr Sathyapala completed her junior doctor training in Oxford and London and completed her specialist Respiratory and General Internal Medicine training in the North-West Thames region, in hospitals including the Hammersmith, Harefield and the Royal Brompton Hospitals. She was awarded a Wellcome Trust Clinical Research Training Fellowship to complete her PhD (awarded 2011) in Professor Mike Polkey’s lab at the Royal Brompton Hospital, which also included a year abroad in the Netherlands, at Maastricht University in Professor Annemie Schols’ lab. Dr Sathyapala was awarded a HEFCE Clinical Senior Lectureship; since 2012, she has been a Senior Lecturer and a Principal Investigator at the NHLI and an Consultant Physician at the Royal Brompton and Harefield NHS Foundation Trust. She was elected as Fellow to the Royal College of Physicians in April 2015.



Much of Dr Sathyapala’s work, to date, has been on skeletal muscle dysfunction in COPD, and other chronic diseases and in ageing, and in molecular mechanisms that may underlie the muscle dysfunction and which may be amenable to drug treatment. This is a small field but one of growing importance as skeletal muscle dysfunction is an important cause of frailty, which is a growing problem in ageing populations. To raise awareness of importance of this problem and to foster collaborative working between basic and clinical scientists with common interests, Dr Sathyapala hosted the first international symposium on ‘Skeletal muscle oxidative metabolism as a target for treating human disease’ at the NHLI in 2016.

Dr Sathyapala’s research is now encompassing research relating to obstructive sleep apnoea, and how to address the problems of poor CPAP adherence and how sleep services can adapt to meet the increasing demand for CPAP.



Dr Sathyapala’s clinical expertise is in sleep, ventilation, and skeletal muscles. This includes: respiratory failure, particularly chronic ventilatory failure requiring non-invasive ventilation, as a result of conditions such as COPD, bronchiectasis, chest wall disease, lung fibrosis, or during weaning after transplantation for example. She also has expertise in diagnosis and management of respiratory muscle weakness, sleep-disordered breathing, such as obstructive sleep apnoea and obesity hypoventilation syndrome and other common sleep disorders such as restless legs syndrome/periodic limb movement disorder. She is also accredited to deliver Cognitive Behavioural Therapy for Insomnia.

Selected Publications

Journal Articles

Lewis A, Donaldson AV, Natanek SA, et al., 2016, Increased expression of H19/miR-675 is associated with a low fat free mass index in patients with COPD, Journal of Cachexia, Sarcopenia and Muscle, Vol:7, ISSN:2190-6009, Pages:330-344

Patel MS, Lee J, Baz M, et al., 2015, Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo, Journal of Cachexia, Sarcopenia and Muscle, Vol:7, ISSN:2190-6009, Pages:436-448

More Publications