Publications
56 results found
Patel MS, Donaldson AV, Lewis A, et al., 2013, Serum And Quadriceps Expression Of Klotho In Smokers And COPD Patients, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
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- Citations: 1
Maddocks M, Shrikrishna D, Vitoriano S, et al., 2012, PHYSICAL INACTIVITY IS ASSOCIATED WITH MID-THIGH INTRAMUSCULAR FAT IN PATIENTS WITH COPD, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A98-A98, ISSN: 0040-6376
Shrikrishna D, Tanner RJ, Lee JY, et al., 2012, THE EFFECT OF ANGIOTENSIN-CONVERTING ENZYME INHIBITION ON SKELETAL MUSCLE DYSFUNCTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A RANDOMISED CONTROLLED TRIAL, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A25-A25, ISSN: 0040-6376
Riddoch-Contreras J, George T, Natanek SA, et al., 2012, p38 Mitogen-activated Protein Kinase is Not Activated in the Quadriceps of Patients with Stable Chronic Obstructive Pulmonary Disease, COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol: 9, Pages: 142-150, ISSN: 1541-2555
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- Citations: 15
Lewis A, Riddoch-Contreras J, Natanek SA, et al., 2012, Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD, THORAX, Vol: 67, Pages: 26-34, ISSN: 0040-6376
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- Citations: 118
Natanek SA, 2012, PATHWAYS ASSOCIATED WITH REDUCED QUADRICEPSOXIDATIVE FIBRES AND ENDURANCE IN COPD, European Respiratory Journal
Rationale: Reduced quadriceps endurance in COPD is associated with apredominance of type II glycolytic over type I oxidative fibres (fibre shift, FS) andreduced muscle energy stores. Molecular mechanisms responsible for thisremain unknown. We hypothesised that expression of known regulators of type Ifibres and energy production in quadriceps muscle would differ in COPD patientswith and without FS.Methods: We measured lung function, physical activity, exercise performance,quadriceps strength and endurance (non-volitionally) in 38 GOLD Stage I-IVCOPD patients and 23 healthy age-matched controls. Participants had aquadriceps biopsy; type I and II fibre proportions were determined usingimmunohistochemistry and FS defined using published reference ranges.Calcineurin A, phosphorylated adenosine monophosphate kinase-alpha(phospho-AMPK) and protein kinase A-alpha catalytic subunits were measuredby western blotting and modulators of calcineurin activity, calmodulin, 14-3-3proteins, and myocyte-enriched calcineurin-interacting protein-1 mRNAmeasured by western blotting and qPCR respectively. Downstream, nuclearmyocyte enhancer factor-2 capable of DNA-binding was quantified bytranscription factor ELISA.European Respiratory Journal Page 2 of 96123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960Page 3 of 31Results: Unexpectedly calcineurin expression was higher, while phospho-AMPKwas lower, in COPD patients with than without FS. Phospho-AMPK levelscorrelated with quadriceps endurance in patients.Conclusions: Reduced phospho-AMPK may contribute to reduced quadricepsoxidative capacity and endurance in COPD.
Donaldson AVJ, Lewis A, Natanek A, et al., 2011, INCREASED SKELETAL MUSCLE-SPECIFIC MICRORNA-1 IN THE BLOOD OF COPD PATIENTS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A25-A25, ISSN: 0040-6376
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- Citations: 3
Amanda Natanek S, Riddoch-Contreras J, Sarah Marsh G, et al., 2011, Yin Yang 1 expression and localisation in quadriceps muscle in COPD, ARCHIVOS DE BRONCONEUMOLOGIA, Vol: 47, Pages: 296-302, ISSN: 0300-2896
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- Citations: 21
Thompson AR, Natanek SA, Willis-Owen SA, et al., 2011, Gene Expression Profiling Of Quadriceps Femoris Muscle In COPD, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Natanek SA, Langen RCJ, Gosker HR, et al., 2010, NF-KAPPA B (NF-κB) AND ACTIVATOR PROTEIN-1 (AP-1) DNA BINDING IN THE QUADRICEPS OF COPD PATIENTS, Publisher: B M J PUBLISHING GROUP, Pages: A138-A139, ISSN: 0040-6376
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- Citations: 1
Natanek SA, Gosker HR, Slot I, et al., 2010, MUSCLE FIBRE ATROPHY AND AEROBIC TO ANAEROBIC FIBRE TYPE SHIFT IN THE QUADRICEPS IN COPD, Publisher: B M J PUBLISHING GROUP, Pages: A139-A139, ISSN: 0040-6376
Moore AJ, Soler RS, Cetti EJ, et al., 2010, Sniff nasal inspiratory pressure versus IC/TLC ratio as predictors of mortality in COPD, RESPIRATORY MEDICINE, Vol: 104, Pages: 1319-1325, ISSN: 0954-6111
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- Citations: 30
Man W-C, Natanek SA, Riddoch-Contreras J, et al., 2010, Quadriceps myostatin expression in COPD, European Respiratory Journal, Vol: 36, Pages: 686-688
Lewis A, Riddoch-Contreras J, Natanek SA, et al., 2010, Alterations in MRTF and FHL1 activity contribute to fibre type shift in the quadriceps of patients with COPD., Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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- Citations: 1
Man WD, Sathyapala SA, Riddoch-Contreras J, et al., 2009, QUADRICEPS MUSCLE EXPRESSION OF MYOSTATIN IN PATIENTS WITH COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A39-A39, ISSN: 0040-6376
Lewis A, Sathyapala SA, Riddoch-Contreras J, et al., 2009, REDUCED EXPRESSION AND ACTIVITY OF MYOCARDIN-RELATED TRANSCRIPTION FACTORS CONTRIBUTES TO FIBRE TYPE CHANGES IN THE QUADRICEPS OF PATIENTS WITH COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A134-A134, ISSN: 0040-6376
Swallow EB, Barreiro E, Gosker H, et al., 2009, Quadriceps muscle strength in scoliosis, EUROPEAN RESPIRATORY JOURNAL, Vol: 34, Pages: 1429-1435, ISSN: 0903-1936
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- Citations: 16
Seymour J, Sathyapala SA, Jackson AS, et al., 2009, The prevalence of quadriceps weakness in COPD and the relationship with disease severity, European Respiratory Journal
Seymour JM, Spruit MA, Hopkinson NS, et al., 2009, The Prevalence of Quadriceps Weakness in COPD and the Relationship with Disease Severity, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Seymour JM, Hopkinson N, Jackson A, et al., 2008, REDUCED QUADRICEPS STRENGTH IN EX-SMOKERS WITHOUT CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A17-A18, ISSN: 0040-6376
Sathyapala SA, Marsh GS, Seymour JM, et al., 2008, EFFECT OF REPETITIVE MAGNETIC STIMULATION TRAINING OF THE QUADRICEPS, COMPARED WITH EXERCISE THERAPY, ON QUADRICEPS STRENGTH IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A16-A17, ISSN: 0040-6376
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- Citations: 1
Contreras JR, Sathyapala SA, Marsh GS, et al., 2008, FOUR AND A HALF LIM PROTEIN 1 EXPRESSION AND AKT PHOSPHORYLATION IN QUADRICEPS MUSCLE IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS AND ITS RELATION TO MUSCLE STRENGTH AND PHYSICAL ACTIVITY, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A24-A24, ISSN: 0040-6376
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- Citations: 1
Sathyapala SA, Marsh GS, Hopkinson NS, et al., 2007, Muscle ring finger protein 1 (MuRF-1), atrogin-1 and muscle wasting in COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A137-A138, ISSN: 0040-6376
Sathyapala SA, Marsh GS, Hopkinson NS, et al., 2007, Quadriceps muscle endurance and its relation to physical activity and exercise capacity in COPD, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A54-A55, ISSN: 0040-6376
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- Citations: 1
Sathyapala SA, Kemp P, Polkey MI, 2007, Decreased muscle PPAR concentrations: a mechanism underlying skeletal muscle abnormalities in COPD?, Europeran Respir Journal, Vol: 30, Pages: 191-193
Sathyapala SA, Gupta NK, Westwood JP, et al., 2005, Recurrence of alpha 1-antitrypsin deficiency emphysema on computed tomography (CT) after lung transplantation, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 24, Pages: S103-S103, ISSN: 1053-2498
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