Imperial College London

DrAnaSergijenko

Faculty of MedicineNational Heart & Lung Institute

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 7933a.sergijenko

 
 
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Location

 

180Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Summary

I joined the Gene Therapy Group led by Prof. Uta Griesenbach and Prof. Eric Alton in 2018. Since then I was working to develop core technologies that can advance gene therapy development. I am working to establish ex vivo human lung models such as Air-Liquid-Interface cultures to test our therapeutic lentivirus-based vector. I am also developing a PCR based method to enable quantification of gene transfer on a single cell basis. 

Previously, I completed my PhD in the Stem Cell and Neurotherapies group in Manchester University under supervision of Prof. Brian Bigger. I was developing a haematopoietic stem cell gene therapy for the neurological lysosomal storage disorder, Sanfilippo disease.

I successfully defended my thesis and then continued with cellular based therapies for osteoarthritis as research associate in Aberdeen University. We investigated the mesenchymal stem cell niche in the knee joint and cellular contributions in response to a mechanical articular cartilage injury.

My research interests include lentiviral vector cloning and production, stem cell and primary cell culture for disease modelling, microscopy, and of course anything to do with gene therapy.

 

Selected Publications

Journal Articles

Sergijenko A, Roelofs AJ, Riemen AHK, et al., 2016, Bone marrow contribution to synovial hyperplasia following joint surface injury, Arthritis Research & Therapy, Vol:18, ISSN:1478-6354, Pages:1-11

Sergijenko A, Langford-Smith A, Liao AY, et al., 2013, Myeloid/Microglial Driven Autologous Hematopoietic Stem Cell Gene Therapy Corrects a Neuronopathic Lysosomal Disease, Molecular Therapy, Vol:21, ISSN:1525-0016, Pages:1938-1949

Wilkinson FL, Sergijenko A, Langford-Smith KJ, et al., 2013, Busulfan Conditioning Enhances Engraftment of Hematopoietic Donor-derived Cells in the Brain Compared With Irradiation, Molecular Therapy, Vol:21, ISSN:1525-0016, Pages:868-876

Langford-Smith A, Wilkinson FL, Langford-Smith KJ, et al., 2012, Hematopoietic Stem Cell and Gene Therapy Corrects Primary Neuropathology and Behavior in Mucopolysaccharidosis IIIA Mice, Molecular Therapy, Vol:20, ISSN:1525-0016, Pages:1610-1621

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