Imperial College London
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Avinash R. Shenoy

Faculty of Medicine, Department of Infectious Disease

Reader in Innate Immunity and Infection
 
 
 
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Contact

 

+44 (0)20 7594 3785a.shenoy Website

 
 
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Location

 

4.40AFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Shenoy:2018:10.1007/82_2018_106,
author = {Shenoy, AR and Furniss, RCD and Goddard, PJ and Clements, A},
booktitle = {Escherichia coli, a Versatile Pathogen},
doi = {10.1007/82_2018_106},
editor = {Frankel and Ron},
publisher = {Springer Verlag},
title = {Modulation of host cell processes by T3SS effectors},
url = {http://dx.doi.org/10.1007/82_2018_106},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Two of the enteric Escherichia coli pathotypes-enteropathogenic E. coli (EPEC) and enterohaemorrhagic E. coli (EHEC)-have a conserved type 3 secretion system which is essential for virulence. The T3SS is used to translocate between 25 and 50 bacterial proteins directly into the host cytosol where they manipulate a variety of host cell processes to establish a successful infection. In this chapter, we discuss effectors from EPEC/EHEC in the context of the host proteins and processes that they target-the actin cytoskeleton, small guanosine triphosphatases and innate immune signalling pathways that regulate inflammation and cell death. Many of these translocated proteins have been extensively characterised, which has helped obtain insights into the mechanisms of pathogenesis of these bacteria and also understand the host pathways they target in more detail. With increasing knowledge of the positive and negative regulation of host signalling pathways by different effectors, a future challenge is to investigate how the specific effector repertoire of each strain cooperates over the course of an infection.
AU  - Shenoy,AR
AU  - Furniss,RCD
AU  - Goddard,PJ
AU  - Clements,A
DO  - 10.1007/82_2018_106
PB  - Springer Verlag
PY  - 2018///
TI  - Modulation of host cell processes by T3SS effectors
T1  - Escherichia coli, a Versatile Pathogen
UR  - http://dx.doi.org/10.1007/82_2018_106
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30178263
UR  - http://hdl.handle.net/10044/1/71551
ER  -
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