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@article{Sanchez-Garrido:2020:10.1080/15548627.2020.1783119,
author = {Sanchez-Garrido, J and Shenoy, A},
doi = {10.1080/15548627.2020.1783119},
journal = {Autophagy},
pages = {1571--1591},
title = {Regulation and repurposing of nutrient sensing and autophagy in innate immunity},
url = {http://dx.doi.org/10.1080/15548627.2020.1783119},
volume = {17},
year = {2020}
}

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TY  - JOUR
AB  - Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability promotes cell growth and proliferation and suppresses catabolic processes, such as macroautophagy/autophagy. These effects are mediated by checkpoint kinases such as MTOR (mechanistic target of rapamycin kinase), which is activated by amino acids and growth factors, and AMP-activated protein kinase (AMPK), which is activated by low levels of glucose or ATP. These kinases have wide-ranging activities that can be co-opted by immune cells upon exposure to danger signals, cytokines or pathogens. Here, we discuss recent insight into the regulation and repurposing of nutrient-sensing responses by the innate immune system during infection. Moreover, we examine how natural mutations and pathogen-mediated interventions can alter the balance between anabolic and autophagic pathways leading to a breakdown in tissue homeostasis and/or host defense.
AU  - Sanchez-Garrido,J
AU  - Shenoy,A
DO  - 10.1080/15548627.2020.1783119
EP  - 1591
PY  - 2020///
SN  - 1554-8627
SP  - 1571
TI  - Regulation and repurposing of nutrient sensing and autophagy in innate immunity
T2  - Autophagy
UR  - http://dx.doi.org/10.1080/15548627.2020.1783119
UR  - https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1783119
UR  - http://hdl.handle.net/10044/1/80881
VL  - 17
ER  -

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Avinash R. Shenoy

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