Caspases in immunity & inflammation
My laboratory is broadly interested in understanding the mechanisms of inflammasome signalling. Inflammasomes are molecular complexes that assemble in response to microbe- or danger-signal and activate caspase-1. Other inflammatory caspases, such as caspase-4, -5 (both together represented by a single caspase-11 in the mouse) and caspase-8, also regulate these pathways. My group is interested in these caspases and their contribution to health and disease.
We are studying new cell-intrinsic roles of caspases in inflammation and immunity. See Research Highlights to see our recent work, which was on the cover of Science Signaling.
Anna Crespo, Tereza Masonou, Mark Stringer, Mo Qadar, Amber Sefton, Celia Riaz Nicieza.
Tereza Masonou, Avinash Shenoy, Anna Crespo and Marc Stringer (2018).
Matthew Eldridge, Avinash Shenoy, Julia Sanchez and Philippa Goddard (2016).
Free full-text access to our paper "Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing" is available here: Summary, Abstract, Full text, Reprint
Role of cytoskeleton proteins and innate immunity against bacterial pathogens.
DNA nanodevices and the host response.
Inflammasome signalling pathways in antibacterial host defence.
My group collaborates with several others within and outside the CMBI. We are interested in antibacterial immunity, sterile inflammation and genetic predisposition to inflammatory diseases.
We collaborate with the following groups and are happy to chat to clinicians, chemists and others who are interested in our work.
Eva-Maria Frickel - The Francis Crick Institute
Vanessa Sancho-Shimizu - Section of Paediatrics
Darius Armstrong-James, Imperial College London, Cell death during fungal infection.
Eva Frickel, The Francis Crick Institute, Inflammasome signalling during Toxoplasma infection
Andrew Edwards, Imperial College London, Boosting innate immune response to clear bacterial infections
Vanessa Sancho-Shimizu, Imperial College London, TLR3 signalling, anti-viral immunity, autophagy
Ed Tate, Imperial College London, Chemical biology, protein geranylylation, ubiquitylation
David Holden, Imperial College London, Salmonella Typhimurium, inflammasomes, antimicrobial responses,
Gad Frankel, Imperial College London, Host immunity to pathogenic E. coli
Brian Robertson, Imperial College London, Mechanisms of differential inflammasome activation by clinical isolates of M. tuberculosis
Brijesh Patel, Imperial College London, Therapeutic targeting of necroptosis cell death pathways in COVID-19 ARDS: proof-of-principle
Sandhya S. Visweswariah, Indian Institute of Science, Second messenger signalling, gut physiology and inflammation
Dr. Eva Frickel, The Francis Crick Institute, Mechanisms of detection and defence against Toxoplasma
Abigal Clements, Imperial College London, Inflammasome responses to Shigella infection
Caspases & their targets: Remarkable lives & a famous death, University of Cambridge - InflammaZoom Webinar, Cambridge, UK (Online), 2020
Caspases & their substrates Remarkable lives & A famous death, Francis Crick Institute, London, UK, 2019
Inflammasomes & cell death: Lessons from E. coli, Salmonella & Toxoplasma, MIVIGEC, Montpellier, France, 2019
Forks and Knives for a Meal: p62, caspase-8 and nutrient homeostasis, Francis Crick Institute, London, UK, 2019
Caspases & their substrates: Remarkable lives before the famous death, Indian Institute of Science, Bangalore, India, 2019
Host Genetics, Inflammasomes & Immune disease, Christian Medical College, Vellore, India, 2019
Caspases & Inflammasomes in Immunity & Inflammation, University of Warwick, Warwick, UK, 2018
Bacterial Effectors, Host Genetics & Caspases: A game of rock, paper & scissors, University of Manchester, Manchester, UK, 2018
Caspases & Innate Immunity, EIMID conference - Oxford, Oxford, UK, 2017
New targets of caspases & the host immune response, 14th Aegean Conference on Innate Immunity, Crete, Greece, 2017
Inflammasomes, caspases and antibacterial host-defence, Blizard Institute, London, UK, 2017
Caspase Targets in Host Immunity to Infection, Imperial College London - EMBRACE, London, UK, 2017
Roles of new caspase-targets in immunity and inflammation, Imperial College London, MRC-Apollo Meeting, London, UK, 2017
Antimicrobial Responses of Caspases, Ramnarain Ruia College, Mumbai, India, 2017
Innate Immune Signalling Pathways, Ramnarain Ruia College, Mumbai, India, 2017
Effectors mechanisms of caspases in host responses, Imperial College - Shionogi - ICL Workshop, London, UK, 2016
Effector mechanisms of NLR activation and caspases in innate immunity, University of Cambridge, Cambridge, UK, 2016
Effector Mechanisms of Caspases in Innate Immunity, Indian Institute of Science, Bangalore, India, 2016
New Molecular Rheostats in Inflammasome Signalling Pathways, University of Aberdeen, Aberdeen, 2016
Antibacterial Host Defence via the Inflammasomes, University of Melbourne, Melbourne, Australia
Inflammasome Effectors of Host Defence against Bacterial Infection, University of Plymouth, Plymouth, 2015
Inflammasome Effectors of Host Defence against Bacterial Infection, EIMID conference, Heidelberg, Germany, 2014
Host Defence ‘On Demand’: GBP Family GTPases to the rescue, National Centre for Biological Sciences, Bangalore, India, 2014
Immunity ‘On Demand’: Inducible GTPases, Inflammasomes and Beyond, University College London, London, 2014
GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals., Salk/Nature/Ipsen Symposium on Biological Complexity: Immunity and Inflammation., Salk Institute for Biological Studies, San Diego, USA., 2012
Research Student Supervision
Eldridge,MJE, Inflammasome effector mechanisms in antimicrobial immunity: Novel caspase-1 targets and their roles in host defence
Goddard,PJ, Manipulation of macrophage programmed cell death pathways by Enteropathogenic Escherichia coli
Hamway,Y, Caspase substrates in host defence, and role of bacterial effectors in counteracting them
Sanchez-Garrido,J, Cell intrinsic actions of caspase-1 via its substrates and targets