Imperial College London

Avinash R. Shenoy

Faculty of MedicineDepartment of Infectious Disease

Reader in Innate Immunity and Infection



+44 (0)20 7594 3785a.shenoy Website




4.40AFlowers buildingSouth Kensington Campus




Caspases in immunity & inflammation

My laboratory is broadly interested in understanding the mechanisms of inflammasome signalling. Inflammasomes are molecular complexes that assemble in response to microbe- or danger-signal and activate caspase-1. Other inflammatory caspases, such as caspase-4, -5 (both together represented by a single caspase-11 in the mouse) and caspase-8, also regulate these pathways. My group is interested in these caspases and their contribution to health and disease.  

We are studying new cell-intrinsic roles of caspases in inflammation and immunity. See Research Highlights to see our recent work, which was on the cover of Science Signaling.


Laboratory Members

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Shenoy Group (March 2020)

Shenoy Group (March 2020)

Anna Crespo, Tereza Masonou, Vishwas Mishra, Callum McCarthy, Christy Cheung, Ana Choi.
Shenoy group

Shenoy Group (April 2019)

Anna Crespo, Tereza Masonou, Mark Stringer, Mo Qadar, Amber Sefton, Celia Riaz Nicieza.

Lab 2018Tereza Masonou, Avinash Shenoy, Anna Crespo and Marc Stringer (2018).
Matthew Eldridge, Avinash, Julia Sanchez, Philippa Goddard (Left to Right)

Matthew Eldridge, Avinash Shenoy, Julia Sanchez and Philippa Goddard (2016).

Research highlights

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Science Signaling
Free full-text access to our paper "Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing" is available here: Summary, Abstract, Full text, Reprint

Innate immunity and the cytoskeleton

Role of cytoskeleton proteins and innate immunity against bacterial pathogens.


DNA nanodevices the host response 

DNA nanodevices and the host response.


Simplified view of inflammasome signalling

Inflammasome signalling pathways in antibacterial host defence.


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My group collaborates with several others within and outside the CMBI. We are interested in antibacterial immunity, sterile inflammation and genetic predisposition to inflammatory diseases.

We collaborate with the following groups and are happy to chat to clinicians, chemists and others who are interested in our work. 

Abigail Clements - CMBI

Gad Frankel - CMBI 

Eva-Maria Frickel - The Francis Crick Institute

Brian Robertson - CMBI 

Vanessa Sancho-Shimizu - Section of Paediatrics

Ed Tate - Dept of Chemistry

Sandhya Visweswariah - Indian Institute of Science


Darius Armstrong-James, Imperial College London, Cell death during fungal infection.

Eva Frickel, The Francis Crick Institute, Inflammasome signalling during Toxoplasma infection

Andrew Edwards, Imperial College London, Boosting innate immune response to clear bacterial infections

Vanessa Sancho-Shimizu, Imperial College London, TLR3 signalling, anti-viral immunity, autophagy

Ed Tate, Imperial College London, Chemical biology, protein geranylylation, ubiquitylation

David Holden, Imperial College London, Salmonella Typhimurium, inflammasomes, antimicrobial responses,

Gad Frankel, Imperial College London, Host immunity to pathogenic E. coli

Brian Robertson, Imperial College London, Mechanisms of differential inflammasome activation by clinical isolates of M. tuberculosis

Brijesh Patel, Imperial College London, Therapeutic targeting of necroptosis cell death pathways in COVID-19 ARDS: proof-of-principle

Sandhya S. Visweswariah, Indian Institute of Science, Second messenger signalling, gut physiology and inflammation

Dr. Eva Frickel, The Francis Crick Institute, Mechanisms of detection and defence against Toxoplasma

Abigal Clements, Imperial College London, Inflammasome responses to Shigella infection

Guest Lectures

Caspases & their targets: Remarkable lives & a famous death, University of Cambridge - InflammaZoom Webinar, Cambridge, UK (Online), 2020

Caspases & their substrates Remarkable lives & A famous death, Francis Crick Institute, London, UK, 2019

Inflammasomes & cell death: Lessons from E. coli, Salmonella & Toxoplasma, MIVIGEC, Montpellier, France, 2019

Forks and Knives for a Meal: p62, caspase-8 and nutrient homeostasis, Francis Crick Institute, London, UK, 2019

Caspases & their substrates: Remarkable lives before the famous death, Indian Institute of Science, Bangalore, India, 2019

Host Genetics, Inflammasomes & Immune disease, Christian Medical College, Vellore, India, 2019

Caspases & Inflammasomes in Immunity & Inflammation, University of Warwick, Warwick, UK, 2018

Bacterial Effectors, Host Genetics & Caspases: A game of rock, paper & scissors, University of Manchester, Manchester, UK, 2018

Caspases & Innate Immunity, EIMID conference - Oxford, Oxford, UK, 2017

New targets of caspases & the host immune response, 14th Aegean Conference on Innate Immunity, Crete, Greece, 2017

Inflammasomes, caspases and antibacterial host-defence, Blizard Institute, London, UK, 2017

Caspase Targets in Host Immunity to Infection, Imperial College London - EMBRACE, London, UK, 2017

Roles of new caspase-targets in immunity and inflammation, Imperial College London, MRC-Apollo Meeting, London, UK, 2017

Antimicrobial Responses of Caspases, Ramnarain Ruia College, Mumbai, India, 2017

Innate Immune Signalling Pathways, Ramnarain Ruia College, Mumbai, India, 2017

Effectors mechanisms of caspases in host responses, Imperial College - Shionogi - ICL Workshop, London, UK, 2016

Effector mechanisms of NLR activation and caspases in innate immunity, University of Cambridge, Cambridge, UK, 2016

Effector Mechanisms of Caspases in Innate Immunity, Indian Institute of Science, Bangalore, India, 2016

New Molecular Rheostats in Inflammasome Signalling Pathways, University of Aberdeen, Aberdeen, 2016

Antibacterial Host Defence via the Inflammasomes, University of Melbourne, Melbourne, Australia

Inflammasome Effectors of Host Defence against Bacterial Infection, University of Plymouth, Plymouth, 2015

Inflammasome Effectors of Host Defence against Bacterial Infection, EIMID conference, Heidelberg, Germany, 2014

Host Defence ‘On Demand’: GBP Family GTPases to the rescue, National Centre for Biological Sciences, Bangalore, India, 2014

Immunity ‘On Demand’: Inducible GTPases, Inflammasomes and Beyond, University College London, London, 2014

GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals., Salk/Nature/Ipsen Symposium on Biological Complexity: Immunity and Inflammation., Salk Institute for Biological Studies, San Diego, USA., 2012

Research Staff





Research Student Supervision

Eldridge,MJE, Inflammasome effector mechanisms in antimicrobial immunity: Novel caspase-1 targets and their roles in host defence

Goddard,PJ, Manipulation of macrophage programmed cell death pathways by Enteropathogenic Escherichia coli

Hamway,Y, Caspase substrates in host defence, and role of bacterial effectors in counteracting them

Sanchez-Garrido,J, Cell intrinsic actions of caspase-1 via its substrates and targets