Imperial College London

Dr. Andrew Shevchuk

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Senior Lecturer



+44 (0)20 3313 2362a.shevchuk Website




Commonwealth BuildingHammersmith Campus





My research is primarily focused on the design, development and application of Scanning Ion Conductance Microscopy in combination with other scanning probe and live imaging techniques to a wide range of biological studies. I introduce latest technological advances to ion conductance microscopy and push its performance to the limits aiming to create powerful and versatile technique that can answer questions currently cannot be addressed by other methods. Recent improvements in resolving power and imaging rate have played a pivotal role and made it possible to directly image endo- and exocytosis in living cells. This now opens a possibility for detailed live studies of such important process as receptor cycling, hormone secretion, drug delivery and infection.

Selected Publications

Journal Articles

Bohovyk R, Fedoriuk M, Isaeva E, et al., 2021, Scanning ion conductance microscopy of live human glomerulus, Journal of Cellular and Molecular Medicine, Vol:25, ISSN:1582-1838, Pages:4216-4219

Maynard SA, Pchelintseva E, Zwi-Dantsis L, et al., 2021, IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells, Scientific Reports, Vol:11, ISSN:2045-2322, Pages:1-14

Klenerman D, Korchev Y, Novak P, et al., 2021, Noncontact Nanoscale Imaging of Cells, Annual Review of Analytical Chemistry, Vol:14, ISSN:1936-1327, Pages:347-361

Bednarska J, Novak P, Korchev Y, et al., 2020, Release of insulin granules by simultaneous, high-speed correlative SICM-FCM, Journal of Microscopy, Vol:282, ISSN:0022-2720, Pages:21-29

Bednarska J, Pelchen-Matthews A, Novak P, et al., 2020, Rapid formation of human immunodeficiency virus-like particles., Proceedings of the National Academy of Sciences of the United States of America, Vol:117, ISSN:0027-8424, Pages:21637-21646

Yang H-Q, Perez-Hernandez M, Sanchez-Alonso J, et al., 2020, Ankyrin-G mediates targeting of both Na+ and K-ATP channels to the rat cardiac intercalated disc, Elife, Vol:9, ISSN:2050-084X

Zhang Y, Takahashi Y, Hong SP, et al., 2019, High-resolution label-free 3D mapping of extracellular pH of single living cells, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1-9

Ali T, Bednarska J, Vassilopoulos S, et al., 2019, Correlative SICM-FCM reveals changes in morphology and kinetics of endocytic pits induced by disease-associated mutations in dynamin, The FASEB Journal, Vol:33, ISSN:0892-6638, Pages:8504-8518

Gopal S, Chiappini C, Penders J, et al., 2019, Porous silicon nanoneedles modulate endocytosis to deliver biological payloads, Advanced Materials, Vol:31, ISSN:0935-9648

Zhou Y, Saito M, Miyamoto T, et al., 2018, Nanoscale imaging of primary cilia with scanning ion conductance microscopy, Analytical Chemistry, Vol:90, ISSN:0003-2700, Pages:2891-2895

Cadinu P, Paulose Nadappuram B, Lee DJ, et al., 2017, Single molecule trapping and sensing using dual nanopores separated by a zeptoliter nanobridge, Nano Letters, Vol:17, ISSN:1530-6984, Pages:6376-6384

Shevchuk A, Tokar S, Gopal S, et al., 2016, Angular approach Scanning Ion Conductance Microscopy, Biophysical Journal, Vol:110, ISSN:1542-0086, Pages:2252-2265

Shevchuk AI, Novak P, Taylor M, et al., 2012, An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy, Journal of Cell Biology, Vol:197, ISSN:0021-9525, Pages:499-508

Takahashi Y, Shevchuk AI, Novak P, et al., 2011, Multifunctional nanoprobes for nanoscale chemical imaging and localized chemical delivery at surfaces and interfaces., Angewandte Chemie (international Ed. in English), Vol:50, ISSN:1521-3773, Pages:9638-42

Shevchuk AI, Frolenkov GI, Sánchez D, et al., 2006, Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy, Angewandte Chemie - International Edition, Vol:45, ISSN:1433-7851, Pages:2212-2216

Gorelik J, Shevchuk AI, Frolenkov GI, et al., 2003, Dynamic assembly of surface structures in living cells, Proceedings of the National Academy of Sciences of the United States of America, Vol:100, ISSN:0027-8424, Pages:5819-5822

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