My research is primarily focused on the design, development and application of Scanning Ion Conductance Microscopy in combination with other scanning probe and live imaging techniques to a wide range of biological studies. I introduce latest technological advances to ion conductance microscopy and push its performance to the limits aiming to create powerful and versatile technique that can answer questions currently unaddressable by other methods. Recent improvements in resolving power and imaging rate have played a pivotal role and made it possible to directly image endo- and exocytosis in living cells. This now opens a possibility for detailed live studies of such important process as receptor cycling, hormone secretion, drug delivery and infection.
PhD Studentship - http://www.findaphd.com/search/ProjectDetails.aspx?PJID=61670
et al., 2012, An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy, Journal of Cell Biology, Vol:197, ISSN:0021-9525, Pages:499-508
et al., 2011, Multifunctional nanoprobes for nanoscale chemical imaging and localized chemical delivery at surfaces and interfaces., Angewandte Chemie (international Ed. in English), Vol:50, ISSN:1521-3773, Pages:9638-42
et al., 2006, Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy, Angewandte Chemie - International Edition, Vol:45, ISSN:1433-7851, Pages:2212-2216
et al., 2003, Dynamic assembly of surface structures in living cells, Proceedings of the National Academy of Sciences of the United States of America, Vol:100, ISSN:0027-8424, Pages:5819-5822