Imperial College London
Alternate

Dr. Andrew Shevchuk

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2362a.shevchuk Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Actis:2014:10.1021/nn405612q,
author = {Actis, P and Tokar, S and Clausmeyer, J and Babakinejad, B and Mikhaleva, S and Cornut, R and Takahashi, Y and Cordoba, AL and Novak, P and Shevchuck, AI and Dougan, JA and Kazarian, SG and Gorelkin, PV and Erofeev, AS and Yaminsky, IV and Unwin, PR and Schuhmann, W and Klenerman, D and Rusakov, DA and Sviderskaya, EV and Korchev, YE},
doi = {10.1021/nn405612q},
journal = {ACS Nano},
pages = {875--884},
title = {Electrochemical nanoprobes for single-cell analysis},
url = {http://dx.doi.org/10.1021/nn405612q},
volume = {8},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The measurement of key molecules in individual cells with minimal disruption to the biological milieu is the next frontier in single-cell analyses. Nanoscale devices are ideal analytical tools because of their small size and their potential for high spatial and temporal resolution recordings. Here, we report the fabrication of disk-shaped carbon nanoelectrodes whose radius can be precisely tuned within the range 5–200 nm. The functionalization of the nanoelectrode with platinum allowed the monitoring of oxygen consumption outside and inside a brain slice. Furthermore, we show that nanoelectrodes of this type can be used to impale individual cells to perform electrochemical measurements within the cell with minimal disruption to cell function. These nanoelectrodes can be fabricated combined with scanning ion conductance microscopy probes, which should allow high resolution electrochemical mapping of species on or in living cells.
AU  - Actis,P
AU  - Tokar,S
AU  - Clausmeyer,J
AU  - Babakinejad,B
AU  - Mikhaleva,S
AU  - Cornut,R
AU  - Takahashi,Y
AU  - Cordoba,AL
AU  - Novak,P
AU  - Shevchuck,AI
AU  - Dougan,JA
AU  - Kazarian,SG
AU  - Gorelkin,PV
AU  - Erofeev,AS
AU  - Yaminsky,IV
AU  - Unwin,PR
AU  - Schuhmann,W
AU  - Klenerman,D
AU  - Rusakov,DA
AU  - Sviderskaya,EV
AU  - Korchev,YE
DO  - 10.1021/nn405612q
EP  - 884
PY  - 2014///
SN  - 1936-0851
SP  - 875
TI  - Electrochemical nanoprobes for single-cell analysis
T2  - ACS Nano
UR  - http://dx.doi.org/10.1021/nn405612q
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330542900091&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.acs.org/doi/10.1021/nn405612q
VL  - 8
ER  -
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