Publications
235 results found
Cowie MR, Wegscheider K, Teschler H, 2016, Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure Reply, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 374, Pages: 690-691, ISSN: 0028-4793
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- Citations: 14
Crimi C, Noto A, Princi P, et al., 2016, Domiciliary Non-invasive Ventilation in COPD: An International Survey of Indications and Practices, COPD: Journal of Chronic Obstructive Pulmonary Disease, Vol: 13, Pages: 483-490, ISSN: 1541-2555
Despite the fact that metanalyses and clinical guidelines do not recommend the routine use of domiciliary non-invasive ventilation (NIV) for patients diagnosed with severe stable Chronic Obstructive Pulmonary Disease (COPD) and with chronic respiratory failure, it is common practice in some countries. We conducted an international web-survey of physicians involved in provision of long-term NIV to examine patterns of domiciliary NIV use in patients diagnosed with COPD. The response rate was 41.6%. A reduction of hospital admissions, improvements in quality of life and dyspnea relief were considered as the main expected benefits for patients. Nocturnal oxygen saturation assessment was the principal procedure performed before NIV prescription. Recurrent exacerbations (>3) requiring NIV and failed weaning from in hospital NIV were the most important reasons for starting domiciliary NIV. Pressure support ventilation (PSV) was the most common mode, with "low" intensity settings (PSV-low) the most popular (44.4 ± 30.1%) compared with "high" intensity (PSV-high) strategies (26.9 ± 25.9%), with different geographical preferences. COPD is confirmed to be a common indication for domiciliary NIV. Recurrent exacerbations and failed weaning from in-hospital NIV were the main reasons for its prescription.
Woehrle H, Cowie M, Eulenburg CZ, et al., 2016, Adaptive Servo-Ventilation For Central Sleep Apnea In Heart Failure: Results Of The Serve-Hf On-Treatment Analysis, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Ramsay M, Mandal S, Suh E-S, et al., 2015, Parasternal electromyography to determine the relationship between patient-ventilator asynchrony and nocturnal gas exchange during home mechanical ventilation set-up, THORAX, Vol: 70, Pages: 946-952, ISSN: 0040-6376
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- Citations: 47
Cowie MR, Woehrle H, Wegscheider K, et al., 2015, Adaptive servo-ventilation for central sleep apnea in heart failure, New England Journal of Medicine, Vol: 373, Pages: 1095-1105, ISSN: 1533-4406
BackgroundCentral sleep apnea is associated with poor prognosis and death in patients with heart failure. Adaptive servo-ventilation is a therapy that uses a noninvasive ventilator to treat central sleep apnea by delivering servo-controlled inspiratory pressure support on top of expiratory positive airway pressure. We investigated the effects of adaptive servo-ventilation in patients who had heart failure with reduced ejection fraction and predominantly central sleep apnea.MethodsWe randomly assigned 1325 patients with a left ventricular ejection fraction of 45% or less, an apnea–hypopnea index (AHI) of 15 or more events (occurrences of apnea or hypopnea) per hour, and a predominance of central events to receive guideline-based medical treatment with adaptive servo-ventilation or guideline-based medical treatment alone (control). The primary end point in the time-to-event analysis was the first event of death from any cause, lifesaving cardiovascular intervention (cardiac transplantation, implantation of a ventricular assist device, resuscitation after sudden cardiac arrest, or appropriate lifesaving shock), or unplanned hospitalization for worsening heart failure.ResultsIn the adaptive servo-ventilation group, the mean AHI at 12 months was 6.6 events per hour. The incidence of the primary end point did not differ significantly between the adaptive servo-ventilation group and the control group (54.1% and 50.8%, respectively; hazard ratio, 1.13; 95% confidence interval [CI], 0.97 to 1.31; P=0.10). All-cause mortality and cardiovascular mortality were significantly higher in the adaptive servo-ventilation group than in the control group (hazard ratio for death from any cause, 1.28; 95% CI, 1.06 to 1.55; P=0.01; and hazard ratio for cardiovascular death, 1.34; 95% CI, 1.09 to 1.65; P=0.006).ConclusionsAdaptive servo-ventilation had no significant effect on the primary end point in patients who had heart failure with reduced ejection fraction and predominantly cen
Simonds AK, Reeves EL, 2015, <i>ERJ Open Research</i>: FAQs, EUROPEAN RESPIRATORY JOURNAL, Vol: 46, Pages: 318-320, ISSN: 0903-1936
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- Citations: 1
Frigerio P, Longhini F, Sommariva M, et al., 2015, Bench Comparative Assessment of Mechanically Assisted Cough Devices, RESPIRATORY CARE, Vol: 60, Pages: 975-982, ISSN: 0020-1324
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- Citations: 10
Simonds AK, 2015, Welcome with Open arms!, ERJ Open Research, Vol: 1, ISSN: 2312-0541
ERJ Open Research: a warm welcome from the Chief Editor, Anita K. Simonds http://ow.ly/LwMBP.
Chatwin M, Tan HL, Bush A, et al., 2015, Long term non-invasive ventilation in children: impact on survival and transition to adult care., PLOS One, Vol: 10, Pages: e0125839-e0125839, ISSN: 1932-6203
BACKGROUND: The number of children receiving domiciliary ventilatory support has grown over the last few decades driven largely by the introduction and widening applications of non-invasive ventilation. Ventilatory support may be used with the intention of increasing survival, or to facilitate discharge home and/or to palliate symptoms. However, the outcome of this intervention and the number of children transitioning to adult care as a consequence of longer survival is not yet clear. METHODS: In this retrospective cohort study, we analysed the outcome in children (<17 years) started on home NIV at Royal Brompton Hospital over an 18 year period 1993-2011. The aim was to establish for different diagnostic groups: survival rate, likelihood of early death depending on diagnosis or discontinuation of ventilation, and the proportion transitioning to adult care. RESULTS: 496 children were commenced on home non invasive ventilation; follow-up data were available in 449 (91%). Fifty six per cent (n=254) had neuromuscular disease. Ventilation was started at a median age (IQR) 10 (3-15) years. Thirteen percent (n=59) were less than 1 year old. Forty percent (n=181) have transitioned to adult care. Twenty four percent (n=109) of patients have died, and nine percent (n=42) were able to discontinue ventilatory support. CONCLUSION: Long term ventilation is associated with an increase in survival in a range of conditions leading to ventilatory failure in children, resulting in increasing numbers surviving to adulthood. This has significant implications for planning transition and adult care facilities.
Pearse SS, Sharma R, Wong T, et al., 2015, Accuracy of a pacemaker-derived algorithm for the diagnosis of sleep disordered breathing in heart failure, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 17, Pages: 297-297, ISSN: 1388-9842
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- Citations: 1
Rutkowski A, Chatwin M, Koumbourlis A, et al., 2015, 203rd ENMC international workshop: Respiratory pathophysiology in congenital muscle disorders: Implications for pro-active care and clinical research 13-15 December, 2013, Naarden, The Netherlands, NEUROMUSCULAR DISORDERS, Vol: 25, Pages: 353-358, ISSN: 0960-8966
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- Citations: 9
Mitchell S, Simonds A, Andreas S, et al., 2015, Introducing a core curriculum for respiratory sleep practitioners., Breathe, Vol: 11, Pages: 50-56, ISSN: 1810-6838
The background and purpose of the HERMES (Harmonising Education in Respiratory Medicine for European Specialists) initiative has been discussed at length in previous articles [1-3]. This article aims to provide more detailed and specific insight into the process and methodology of the Sleep HERMES Task Force in developing a core curriculum in respiratory sleep medicine.
Mitchell S, Bloch KE, Butiene I, et al., 2014, "Education is the passport to the future": enabling today's medical teachers to prepare tomorrow's respiratory health practitioners, EUROPEAN RESPIRATORY JOURNAL, Vol: 44, Pages: 578-584, ISSN: 0903-1936
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- Citations: 7
Artigas A, Noel J-L, Brochard L, et al., 2014, Defining a training framework for clinicians in respiratory critical care, EUROPEAN RESPIRATORY JOURNAL, Vol: 44, Pages: 572-577, ISSN: 0903-1936
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- Citations: 3
Carlisle T, Carthy ER, Glasser M, et al., 2014, Upper airway factors that protect against obstructive sleep apnoea in healthy older males, EUROPEAN RESPIRATORY JOURNAL, Vol: 44, Pages: 685-693, ISSN: 0903-1936
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- Citations: 26
Kelly JL, Jaye J, Pickersgill RE, et al., 2014, Randomized trial of 'intelligent' autotitrating ventilation versus standard pressure support non-invasive ventilation: Impact on adherence and physiological outcomes, RESPIROLOGY, Vol: 19, Pages: 596-603, ISSN: 1323-7799
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- Citations: 53
Migliori GB, Rabe KF, Bel E, et al., 2014, The European Respiratory Society plans its future: the 2013-2018 strategic plan, EUROPEAN RESPIRATORY JOURNAL, Vol: 43, Pages: 927-932, ISSN: 0903-1936
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- Citations: 13
Cowie MR, Woehrle H, Wegscheider K, et al., 2014, Rationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure, European Journal of Heart Failure, Vol: 15, Pages: 937-943, ISSN: 1879-0844
AimsCentral sleep apnoea/Cheyne–Stokes respiration (CSA/CSR) is a risk factor for increased mortality and morbidity in heart failure (HF). Adaptive servo-ventilation (ASV) is a non-invasive ventilation modality for the treatment of CSA/CSR in patients with HF.MethodsSERVE-HF is a multinational, multicentre, randomized, parallel trial designed to assess the effects of addition of ASV (PaceWave™, AutoSet CS™; ResMed) to optimal medical management compared with medical management alone (control group) in patients with symptomatic chronic HF, LVEF ≤45%, and predominant CSA. The trial is based on an event-driven group sequential design, and the final analysis will be performed when 651 events have been observed or the study is terminated at one of the two interim analyses. The aim is to randomize ∼1200 patients to be followed for a minimum of 2 years. Patients are to stay in the trial up to study termination. The first patient was randomized in February 2008 and the study is expected to end mid 2015. The primary combined endpoint is the time to first event of all-cause death, unplanned hospitalization (or unplanned prolongation of a planned hospitalization) for worsening (chronic) HF, cardiac transplantation, resuscitation of sudden cardiac arrest, or appropriate life-saving shock for ventricular fibrillation or fast ventricular tachycardia in implantable cardioverter defibrillator patients.PerspectivesThe SERVE-HF study is a randomized study that will provide important data on the effect of treatment with ASV on morbidity and mortality, as well as the cost-effectiveness of this therapy, in patients with chronic HF and predominantly CSA/CSR.Trial registrationISRCTN19572887
Hopkinson N, Wallis C, Higgins B, et al., 2013, CIGARETTE PACKAGING Children must be protected from the tobacco industry's marketing tactics, BMJ-BRITISH MEDICAL JOURNAL, Vol: 347, ISSN: 1756-1833
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- Citations: 1
Simonds AK, Hare A, 2013, New modalities for non-invasive ventilation., Clin Med (Lond), Vol: 13 Suppl 6, Pages: s41-s45
There is now substantial evidence supporting the use of non-invasive ventilation in acute hypercpanic exacerbations of chronic respiratory failure, and early trials show nocturnal ventilatory support may benefit chronic heart failure patients with sleep disordered breathing. Attention is now being focused on innovative modes which adapt respiratory support to the user's ventilatory pattern, eg adaptive service ventilation and assured volume delivery 'intelligent' ventilation.
Ward NR, Roldao V, Cowie MR, et al., 2013, The Effect of Respiratory Scoring on the Diagnosis and Classification of Sleep Disordered Breathing in Chronic Heart Failure, SLEEP, Vol: 36, Pages: 1341-1348, ISSN: 0161-8105
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- Citations: 21
Simonds AK, 2013, Chronic hypoventilation and its management., Eur Respir Rev, Vol: 22, Pages: 325-332
While obstructive sleep apnoea syndrome dominates discussion of the prevalence of sleep disordered breathing, nocturnal hypoventilation remains extremely prevalent in those with chronic ventilatory disorders and in the natural history of these conditions pre-dates the development of daytime ventilatory failure. In this review the clinical management of chronic hypoventilation in neuromuscular disease will be considered and then compared with that in obesity hypoventilation syndrome. In simple terms these conditions illustrate the polar opposite ends of the spectrum, as in neuromuscular disease the reduced capacity of the respiratory system is unable to withstand a normal respiratory load, and in obesity hypoventilation syndrome the normal capacity of the respiratory system is unable to tolerate a substantially increased ventilatory load.
Hare A, Chatwin M, Hind M, et al., 2013, Percutaneous gastrostomy (PEG) insertion under general anaesthesia (GA) in ventilator-dependent patients with neuromuscular disease (NMD), EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Savage HO, Khushaba R, Bateman P, et al., 2013, Cheyne Stokes respiration in patients with heart failure detected by a novel non-contact monitor of nocturnal respiration, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S1-S1, ISSN: 1388-9842
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- Citations: 2
Chatwin M, Bush A, Macrae DJ, et al., 2013, Risk management protocol for gastrostomy and jejunostomy insertion in ventilator dependent infants, NEUROMUSCULAR DISORDERS, Vol: 23, Pages: 289-297, ISSN: 0960-8966
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- Citations: 7
Simonds AK, 2013, Palliating breathlessness in patients with advanced cancer, LANCET ONCOLOGY, Vol: 14, Pages: 181-182, ISSN: 1470-2045
Ward NR, Cowie MR, Rosen SD, et al., 2012, Utility of overnight pulse oximetry and heart rate variability analysis to screen for sleep-disordered breathing in chronic heart failure, THORAX, Vol: 67, Pages: 1000-1005, ISSN: 0040-6376
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- Citations: 27
Ricotti V, Engledow E, Emmanuel A, et al., 2012, Recurrent pseudo-obstruction and sigmoid volvulus in Duchenne Muscular Dystrophy: A case report, 17th International Congress of the World-Muscle-Society (WMS), Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 887-888, ISSN: 0960-8966
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- Citations: 2
Murphy PB, Davidson C, Hind MD, et al., 2012, Volume targeted versus pressure support non-invasive ventilation in patients with super obesity and chronic respiratory failure: a randomised controlled trial, THORAX, Vol: 67, Pages: 727-734, ISSN: 0040-6376
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- Citations: 150
Hull J, Aniapravan R, Chan E, et al., 2012, British Thoracic Society guideline for respiratory management of children with neuromuscular weakness, THORAX, Vol: 67, Pages: 1-40, ISSN: 0040-6376
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- Citations: 220
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