Publications
235 results found
Meadows GE, Kotajima F, Vazir A, et al., 2005, Overnight changes in the cerebral vascular response to isocapnic hypoxia and hypercapnia in healthy humans - Protection against stroke, STROKE, Vol: 36, Pages: 2367-2372, ISSN: 0039-2499
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- Citations: 26
Simonds AK, 2005, Ethical aspects of home long term ventilation in children with neuromuscular disease., Paediatr Respir Rev, Vol: 6, Pages: 209-214, ISSN: 1526-0542
Increasing numbers of children and young adults are now receiving home ventilation. Whereas in some neuromuscular conditions the outcome and quality of life gains are clear cut; in others eg Spinal Muscular Atrophy Type I there are a few outcome studies with conflicting results and it is more difficult to balance the ethical concepts of beneficence, non-maleficence, autonomy and distributive justice. As a result there are widespread variations in the clinical management of these children. This article examines decision-making in these areas seen from the perspective of the individual, the family and society.
Nickol AH, Hart N, Hopkinson NS, et al., 2005, Mechanisms of improvement of respiratory failure in patients with restrictive thoracic disease treated with non-invasive ventilation, THORAX, Vol: 60, Pages: 754-760, ISSN: 0040-6376
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- Citations: 84
Bush A, Fraser J, Jardine E, et al., 2005, Respiratory management of the infant with type 1 spinal muscular atrophy, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 90, Pages: 709-711, ISSN: 0003-9888
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- Citations: 36
Vazir A, Hastings PC, Duncan AM, et al., 2005, Cardiac dysynchrony as measured by total isovolumic time may predispose to central sleep apnoea in chronic heart failure, Annual Conference of G-MEX/MICC, Publisher: B M J PUBLISHING GROUP, Pages: A21-A21, ISSN: 1355-6037
O'Driscoll DM, Kostikas K, Simonds AK, et al., 2005, Occlusion of the upper airway does not augment the cardiovascular response to arousal from sleep in humans, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 98, Pages: 1349-1355, ISSN: 8750-7587
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- Citations: 8
Simonds AK, 2005, Streamlining weaning: protocols and weaning units, THORAX, Vol: 60, Pages: 175-177, ISSN: 0040-6376
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- Citations: 14
Lloyd-Owen SJ, Donaldson GC, Ambrosino N, et al., 2005, Patterns of home mechanical ventilation use in Europe: results from the Eurovent survey, Eur Respir J, Vol: 25, Pages: 1025-1031, ISSN: 0903-1936
The study was designed to assess the patterns of use of home mechanical ventilation (HMV) for patients with chronic respiratory failure across Europe. A detailed questionnaire of centre details, HMV user characteristics and equipment choices was sent to carefully identified HMV centres in 16 European countries. A total of 483 centres treating 27,118 HMV users were identified. Of these, 329 centres completed surveys between July 2001 and June 2002, representing up to 21,526 HMV users and a response rate of between 62% and 79%. The estimated prevalence of HMV in Europe was 6.6 per 100,000 people. The variation in prevalence between countries was only partially related to the median year of starting HMV services. In addition, there were marked differences between countries in the relative proportions of lung and neuromuscular patients using HMV, and the use of tracheostomies in lung and neuromuscular HMV users. Lung users were linked to a HMV duration of <1 yr, thoracic cage users with 6-10 yrs of ventilation and neuromuscular users with a duration of > or =6 yrs. In conclusion, wide variations exist in the patterns of home mechanical ventilation provision throughout Europe. Further work is needed to monitor its use and ensure equality of provision and access.
Farre R, Lloyd-Owen SJ, Ambrosino N, et al., 2005, Quality control of equipment in home mechanical ventilation: a European survey, European Respiratory Journal, Vol: 26, Pages: 86-94, ISSN: 0903-1936
Chatwin M, Ward S, Nickol AH, et al., 2004, A randomised trial of outpatient versus inpatient initiation of non-invasive ventilation in nocturnal hypoventilation due to neuromuscular and chest wall disease, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 30-30, ISSN: 0040-6376
Meadows GE, O'Driscoll DM, Simonds AK, et al., 2004, Cerebral blood flow response to isocapnic hypoxia during slow-wave sleep and wakefulness, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 97, Pages: 1343-1348, ISSN: 8750-7587
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- Citations: 39
Vazir A, Dayer M, Jonville S, et al., 2004, Prevalence and underlying mechanism of sleep disordered breathing in congestive heart failure, ESC Congress 2004, Publisher: W B SAUNDERS CO LTD, Pages: 648-648, ISSN: 0195-668X
Simonds AK, 2004, Pneumothorax: an important complication of non-invasive ventilation in neuromuscular disease, NEUROMUSCULAR DISORDERS, Vol: 14, Pages: 351-352, ISSN: 0960-8966
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- Citations: 13
Vazir A, Minnion RH, Dayer M, et al., 2004, Prevalence and characteristics of sleep disordered breathing (SDB) in varying levels of congestive heart failure (CHF), Annual Conference of the British-Cardiac-Society, Publisher: B M J PUBLISHING GROUP, Pages: A6-A6, ISSN: 1355-6037
Polkey MI, Morrell MJ, Simonds AK, 2004, Apnea and history, CHEST, Vol: 125, Pages: 1587-1588, ISSN: 0012-3692
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- Citations: 1
Simonds AK, 2004, Home mechanical ventilation, the UK perspective, REVUE DES MALADIES RESPIRATOIRES, Vol: 21, Pages: 350-353, ISSN: 0761-8425
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- Citations: 3
Shneerson JM, Simonds AK, 2004, Noninvasive ventilation or paradigm paralysis?, EUROPEAN RESPIRATORY JOURNAL, Vol: 23, Pages: 651-651, ISSN: 0903-1936
O'Driscoll DM, Meadows GE, Corfield DR, et al., 2004, Cardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 96, Pages: 865-870, ISSN: 8750-7587
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- Citations: 22
Bennett JR, Dunroy HMA, Corfield DR, et al., 2004, Respiratory muscle activity during REM sleep in patients with diaphragm paralysis, NEUROLOGY, Vol: 62, Pages: 134-137, ISSN: 0028-3878
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- Citations: 29
Simonds AK, 2004, Living and dying with respiratory failure: facilitating decision making., Chron Respir Dis, Vol: 1, Pages: 56-59, ISSN: 1479-9723
Respiratory failure is a predictable cause of death in end stage lung disease including COPD and neuromuscular disorders, and the symptom burden for these individuals in the last six months of life is significant. Palliative care services are less well-developed for patients with chronic disorders compared to those with malignant disease; and communication problems can be compounded by a mismatch in expectations between patients and health care providers on prognosis and other issues. Most patients want more information about their illness to facilitate participation in decision making. Noninvasive ventilation may extend life and palliate symptoms in neuromuscular disorders such as Duchenne muscular dystrophy and motor neurone disease/ALS.
Szollosi I, Jones M, Morrell MJ, et al., 2004, Effect of CO<sub>2</sub> inhalation on central sleep apnea and arousals from sleep, RESPIRATION, Vol: 71, Pages: 493-498, ISSN: 0025-7931
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- Citations: 54
Kinali M, Mercuri E, Gibson BE, et al., 2003, UK physicians' attitudes and practises in long term non-invasive ventilation of children with Duchenne Muscular Dystrophy, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 79-79, ISSN: 0040-6376
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- Citations: 1
Vazir A, Kostikas K, Minnion RH, et al., 2003, Subjective sleepiness in heart failure patients with sleep disordered breathing compared to controls, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 7-8, ISSN: 0040-6376
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- Citations: 1
Vazir A, Minnion RH, Dayer M, et al., 2003, Night to night variation in apnea and hypopnea index in patients with established congestive heart failure and recently diagnosed sleep disordered breathing, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 8-8, ISSN: 0040-6376
Simonds AK, 2003, Home ventilation, Symposium on Respiratory Failure, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, Pages: 38S-46S, ISSN: 0903-1936
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- Citations: 86
Simonds AK, 2003, Home ventilation., Eur Respir J Suppl, Vol: 47, Pages: 38s-46s, ISSN: 0904-1850
Home ventilation is a growth area. Rapid expansion during the 1990s was stimulated by the development of noninvasive ventilation (NIV) via a mask and the recognition that an increased number of patient groups can benefit. Although patients receiving NIV in the home outnumber those receiving invasive ventilation via tracheostomy, there is substantial variation in practice between European countries. Evidence that individuals who develop ventilatory failure as a consequence of chest wall disease or stable neuromuscular disease such as old poliomyelitis benefit from nocturnal NIV is overwhelming. Patients with progressive neuromuscular disease such as Duchenne muscular dystrophy and amyotrophic lateral sclerosis can also derive prolongation of life, palliation of symptoms and an improvement in quality of life. Home ventilation in chronic obstructive pulmonary disease (COPD) patients remains controversial. Multicentric randomised controlled trials of long-term oxygen therapy (LTOT) versus NIV plus LTOT in COPD have produced mixed results, although certain subgroups, e.g. those with recurrent infective exacerbations requiring short-term NIV, patients aged >65 yrs, and those with uncontrolled hypercapnia on LTOT or symptomatic nocturnal hypoventilation, may benefit. At the other end of the age spectrum, children as young as a few months can be successfully treated with noninvasive ventilation. Most work on paediatric home ventilation centres on children with congenital neuromuscular disease. Pressure preset bilevel ventilators are now the dominant form of ventilator in adults and children. Discharge planning is vital for the home ventilator patient and a sensible risk management strategy should be in place.
Browne HAK, Adams L, Simonds AK, et al., 2003, Sleep-apnoea and daytime function in the elderly - what is the impact of arousal frequency?, RESPIRATORY MEDICINE, Vol: 97, Pages: 1102-1108, ISSN: 0954-6111
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- Citations: 14
Hart N, Simonds AK, 2003, The pulmonary physician in critical care - Illustrative case 4: Neuromusculoskeletal disorders, THORAX, Vol: 58, Pages: 547-549, ISSN: 0040-6376
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- Citations: 2
Rao A, Georgiadou P, Johnson A, et al., 2003, The prevalence of sleep disordered breathing in a UK heart failure clinic population and its relation to urinary catecholamines, Annual Scientific Conference of the British-Cardiac-Society, Publisher: B M J PUBLISHING GROUP, Pages: A7-A7, ISSN: 1355-6037
Chatwin M, Ross E, Hart N, et al., 2003, Cough augmentation with mechanical insufflation/exsufflation in patients with neuromuscular weakness, EUROPEAN RESPIRATORY JOURNAL, Vol: 21, Pages: 502-508, ISSN: 0903-1936
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- Citations: 229
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