Imperial College London
Alternate

Emeritus ProfessorAnitaSimonds

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Respiratory & Sleep Medicine
 
 
 
//

Contact

 

+44 (0)20 7351 8911a.simonds

 
 
//

Location

 

Office by Sleep LabsFulham RoadRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Wimms:2020:10.1016/S2213-2600(19)30402-3,
author = {Wimms, AJ and Kelly, JL and Turnbull, CD and McMillan, A and Craig, SE and O'Reilly, JF and Nickol, AH and Hedley, EL and Decker, MD and Willes, LA and Calverley, PMA and Benjafield, AV and Stradling, JR and Morrell, MJ and MERGE, trial investigators},
doi = {10.1016/S2213-2600(19)30402-3},
journal = {The Lancet Respiratory Medicine},
pages = {349--358},
title = {Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial},
url = {http://dx.doi.org/10.1016/S2213-2600(19)30402-3},
volume = {8},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The evidence base for the treatment of mild obstructive sleep apnoea is limited and definitions of disease severity vary. The MERGE trial investigated the clinical effectiveness of continuous positive airway pressure in patients with mild obstructive sleep apnoea. METHODS: MERGE, a multicentre, parallel, randomised controlled trial enrolled patients (≥18 years to ≤80 years) with mild obstructive sleep apnoea (apnoea-hypopnoea index [AHI] ≥5 to ≤15 events per h using either AASM 2007 or AASM 2012 scoring criteria) from 11 UK sleep centres. Participants were assigned (1:1) to either 3 months of continuous positive airway pressure plus standard care (sleep counselling), or standard care alone, by computer-generated randomisation; neither participants nor researchers were blinded. The primary outcome was a change in the score on the Short Form-36 questionnaire vitality scale in the intention-to-treat population of patients with mild obstructive sleep apnoea diagnosed using the American Academy of Sleep Medicine 2012 scoring criteria. The study is registered with ClinicalTrials.gov, NCT02699463. FINDINGS: Between Nov 28, 2016 and Feb 12, 2019, 301 patients were recruited and randomised. 233 had mild obstructive sleep apnoea using AASM 2012 criteria and were included in the intention-to-treat analysis: 115 were allocated to receive continuous positive airway pressure and 118 to receive standard care. 209 (90%) of these participants completed the trial. The vitality score significantly increased with a treatment effect of a mean of 10·0 points (95% CI 7·2-12·8; p<0·0001) after 3 months of continuous positive airway pressure, compared with standard care alone (9·2 points [6·8 to 11·6] vs -0·8 points [-3·2 to 1·5]). Using the ANCOVA last-observation-carried-forward analysis, a more conservative estimate, the vitality score also significantly increased with a treatment effect of a
AU  - Wimms,AJ
AU  - Kelly,JL
AU  - Turnbull,CD
AU  - McMillan,A
AU  - Craig,SE
AU  - O'Reilly,JF
AU  - Nickol,AH
AU  - Hedley,EL
AU  - Decker,MD
AU  - Willes,LA
AU  - Calverley,PMA
AU  - Benjafield,AV
AU  - Stradling,JR
AU  - Morrell,MJ
AU  - MERGE,trial investigators
DO  - 10.1016/S2213-2600(19)30402-3
EP  - 358
PY  - 2020///
SN  - 2213-2600
SP  - 349
TI  - Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial
T2  - The Lancet Respiratory Medicine
UR  - http://dx.doi.org/10.1016/S2213-2600(19)30402-3
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31806413
UR  - https://www.sciencedirect.com/science/article/pii/S2213260019304023?via%3Dihub
UR  - http://hdl.handle.net/10044/1/76362
VL  - 8
ER  -
Download