Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences (Silwood Park)




+44 (0)20 7589 5111 ext 55409a.simoni




Sir Alexander Fleming BuildingSouth Kensington Campus





I was born in Italy in 1981. After graduating in Molecular Biology at the University of Padova, I moved to England, first at Leicester, then to London where I obtained my PhD at the Queen Mary University of London studying the genetic pathways that lead to synchronization of the circadian clock of Drosophila melanogaster. I then joined Imperial in 2011 as a PostDoc Research Associate in the lab of Andrea Crisanti, focused on developing novel strategy to control malaria.

Selected Publications

Journal Articles

Hammond A, Pollegioni P, Persampieri T, et al., 2021, Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field., Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-9

Garrood WT, Kranjc N, Petri K, et al., 2021, Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito, Proceedings of the National Academy of Sciences of the United States of America, Vol:118, ISSN:0027-8424

Annas GJ, Beisel CL, Clement K, et al., 2021, A Code of Ethics for Gene Drive Research, Crispr Journal, Vol:4, ISSN:2573-1599

Simoni A, Hammond AM, Beaghton AK, et al., 2020, A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae, Nature Biotechnology, Vol:38, ISSN:1087-0156, Pages:1054-1060

Hammond A, Galizi R, Kyrou K, et al., 2016, A CRISPR-Cas9 gene drive system-targeting female reproduction in the malaria mosquito vector Anopheles gambiae, Nature Biotechnology, Vol:34, ISSN:1087-0156, Pages:78-83

Dritsou V, Topalis P, Windbichler N, et al., 2015, A draft genome sequence of an invasive mosquito: an Italian <i>Aedes</i> <i>albopictus</i>, Pathogens and Global Health, Vol:109, ISSN:2047-7724, Pages:207-220

Simoni A, Siniscalchi C, Chan Y-S, et al., 2014, Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster, Nucleic Acids Research, Vol:42, ISSN:1362-4962, Pages:7461-7472

Simoni A, Wolfgang W, Topping MP, et al., 2014, A Mechanosensory Pathway to the <i>Drosophila</i> Circadian Clock, Science, Vol:343, ISSN:0036-8075, Pages:525-528

Wolfgang W, Simoni A, Gentile C, et al., 2013, The Pyrexia transient receptor potential channel mediates circadian clock synchronization to low temperature cycles in <i>Drosophila melanogaster</i>, Proceedings of the Royal Society B: Biological Sciences, Vol:280, ISSN:0962-8452, Pages:20130959-20130959

Gentile C, Sehadova H, Simoni A, et al., 2013, Cryptochrome Antagonizes Synchronization of Drosophila’s Circadian Clock to Temperature Cycles, Current Biology, Vol:23, ISSN:0960-9822, Pages:185-195

Wolfgang W, Simoni A, Joerg AT, et al., 2012, Synchronization of the <i>Drosophila</i> circadian clock by temperature, humidity and mechanical stimulation, Journal of Neurogenetics, Vol:26, ISSN:0167-7063, Pages:12-13

Wolfgang W, Gentile C, Simoni A, et al., 2010, Trp-channels affect temperature entrainment of the circadian clock in <i>Drosophila melanogaster</i>, Journal of Neurogenetics, Vol:24, ISSN:0167-7063, Pages:55-56

Simoni A, Stanewsky R, 2010, The DN2 clock neurons regulate period and phase of eclosion rhythms during temperature entrainment, Journal of Neurogenetics, Vol:24, ISSN:0167-7063, Pages:26-26

Sehadova H, Glaser FT, Gentile C, et al., 2009, Temperature Entrainment of <i>Drosophila</i>'s Circadian Clock Involves the Gene <i>nocte</i> and Signaling from Peripheral Sensory Tissues to the Brain, Neuron, Vol:64, ISSN:0896-6273, Pages:251-266

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