Imperial College London
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DrAlexandrosSiskos

Faculty of Medicine, Department of Surgery & Cancer

Honorary Research Fellow
 
 
 
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Contact

 

a.siskos Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chatziioannou:2017:10.1038/srep42870,
author = {Chatziioannou, A and Georgiadis, P and Hebels, DG and Liampa, I and Valavanis, I and Bergdahl, IA and Johansson, A and Palli, D and Chadeau-Hyam, M and Siskos, AP and Keun, H and Botsivali, M and de, Kok TMCM and Perez, AE and Kleinjans, JCS and Vineis, P and Kyrtopoulos, SA},
doi = {10.1038/srep42870},
journal = {SCIENTIFIC REPORTS},
title = {Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases},
url = {http://dx.doi.org/10.1038/srep42870},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.
AU  - Chatziioannou,A
AU  - Georgiadis,P
AU  - Hebels,DG
AU  - Liampa,I
AU  - Valavanis,I
AU  - Bergdahl,IA
AU  - Johansson,A
AU  - Palli,D
AU  - Chadeau-Hyam,M
AU  - Siskos,AP
AU  - Keun,H
AU  - Botsivali,M
AU  - de,Kok TMCM
AU  - Perez,AE
AU  - Kleinjans,JCS
AU  - Vineis,P
AU  - Kyrtopoulos,SA
DO  - 10.1038/srep42870
PY  - 2017///
SN  - 2045-2322
TI  - Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases
T2  - SCIENTIFIC REPORTS
UR  - http://dx.doi.org/10.1038/srep42870
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394760400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/45816
VL  - 7
ER  -
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